Résultats de recherche

L’Université de Namur affiche d’encourageants résultats dans le prestigieux classement Positive Impact Rating (PIR), se maintenant dans la catégorie “Progressing” pour la deuxième année consécutive. Avec un score amélioré de 7,0/10, l’UNamur démontre une fois de plus son engagement envers les défis sociétaux et son rôle pionnier dans l’éducation responsable.

Le département s’organise à travers le Conseil de département, qui réunit l’ensemble des professeurs et assistants chercheurs du département. La gestion des programmes de Bachelier et de Master est assurée par les Responsables de programme. Ils s’occupent entre autres de la validation des programmes annuels de l’étudiant (PAE) ainsi que des admissions. 

Le département s’organise à travers le Conseil de département, qui réunit l’ensemble des professeurs et assistants chercheurs du département.La gestion des programmes de Bachelier et de Master est assurée par les Responsables de programme. Ils s’occupent entre autres de la validation des programmes annuels de l’étudiant (PAE) ainsi que des admissions.

Le F.R.S.-FNRS a publié ce 25 juin 2024, la liste des lauréats aux différents mandats doctorants et postdoctorants. Parmi ceux-ci, 16 chercheurs de l'Université de Namur ont obtenu des financements.

Sujet de la Dissertation Reducing the Effects of Information Overload on Governments Decision-Making: Empirical Frameworks to Support Data Selection Composition du Jury Promoteurs :Prof. Corentin Dumay, Université de NamurProf. Isabelle Linden, Université de NamurAutres membres du Jury :Dr. Jonathan Crusoe, Université de GothenburgProf. Manuel Kolp, Université Catholique de LouvainProf. Anthony Simonofski, Université de NamurPrésident du Jury :Prof. Jean-Yves Gnabo, Université de Namur

Rejoignez-nous lors de cette journée scientifique organisée en l'honneur du Professeur Yves Poumay, afin de célébrer sa remarquable carrière de chercheur dans le domaine de la biologie et physiopathologie cutanée. Au programme: des conférences scientifiques données par des orateurs invités, des communications orales et des posters présentés par des jeunes chercheurs, une rétrospective de la carrière d’Yves Poumay, des discours et, pour clôturer en beauté, un drink festif suivi d’un walking dinner.Un appel à abstract est ouvert ! Les jeunes chercheurs actifs dans le domaine de la recherche cutanée sont invités à soumettre un abstract pour une courte communication orale ou la présentation d'un poster.  Plus d'infos sur la page web sur le site de l'Institut NARILIS (voir ci-dessous). Conférenciers invités •    Laure DUMOUTIER, UCLouvain, Institut de Duve•    Gilles LEMAITRE, Université d'Evry/Paris Saclay, Laboratoire de Génomique et Radiobiologie de la Kératinopoïèse•    Bernard MIGNON, Université de Liège, Unité de Recherche de la Faculté de Médecine vétérinaire (FARAH)•    Abdallah MOUND, Université Hassan II de Casablanca, Faculté de Médecine et de Pharmacie•    Arjen NIKKELS, Université de Liège, CHU du Sart Tilman, Service de dermatologie•    Michel SIMON, Université de Toulouse, Institut toulousain des maladies infectieuses et inflammatoires (INFINITY)Nos sponsorsLabconsult | Technigen | MLS | CliniSciences Le comité organisateur Charles Nicaise, Catherine Lambert de Rouvroit, Emilie Faway, Bastien Tirtiaux, Eléa Denil et Valérie De Glas En savoir plus

Consanguinity refers to the offspring produced from the union of two closely related individuals who share at least one common ancestor (Temaj et al. 2022). Some communities have high rates of consanguineous marriages, especially in the Middle East, where consanguinity rates of first-cousin marriages vary in Gulf countries from 20 to 50 % (Ben-Omran et al. 2020). This high rate of consanguineous marriages is due to cultural, geographical, historical, financial, political, or religious reasons (Temaj et al. 2022) (Ben-Omran et al. 2020).Consanguinity increases the chance/risk/probability to be homozygous for rare mutations in the general population (Temaj et al. 2022). These mutations can cause recessive autosomal pathologies that may be extremely rare known as rare diseases (Temaj et al. 2022). In many Middle Eastern populations, consanguineous relationships are very common, providing geneticists with a valuable source for discovering "new" genes and identifying their functions (Ben-Omran et al. 2020). Identifying these genes can help carry out diagnostic and predictive tests (genetic counseling) in affected families (Ben-Omran et al. 2020; Temaj et al. 2022). In some cases, understanding the pathophysiological mechanisms involved in diseases can also lead to new therapeutic strategies (Salzberg 2018).In recent years, the development of Next Generation Sequencing (NGS) technologies has led to a faster identification of genes involved in rare diseases (Lal et al. 2016). Sequencing the entire genome (Whole Genome Sequencing, WGS) or the exome (Whole Exome sequencing, WES) can be achieved quickly and inexpensively (Salzberg 2018).Rare diseases are Mendelian monogenic diseases, that result from specific pathogenic variants in single genes, called germline mutations. These mutations occurring in the coding or the non-coding regions in the gene, can be inherited in dominant, recessive, or X-linked transmission modes within a family (Tukker et al. 2021). Coding sequences, known as exons, directly encode the amino acid sequence of proteins essential for various cellular functions, including enzymatic reactions, cell signaling, and structural support. Pathogenic variants within coding sequences can lead to significant disruptions and alterations in the protein structure, function, and stability (Li et al. 2013).  However non-coding sequences that represents around 98% of the entire human genome, include introns, enhancers, promotors, and regulatory elements that regulate genes’ expression. The presence of a pathogenic variant in one of these regions can alter mRNA processing and gene expression and disrupt the delicate balance of gene regulation. REFERENCEWhile coding regions, constitutes around 1 to 2% of the entire genome, , the precise functions of non-coding regions are still unraveled (Moyon et al. 2022).Our project has two main objectives.A) Firstly, to identify the pathogenic variant responsible for a syndromic neurodevelopmental disorder (NDD) in a young boy from a consanguineous Lebanese family. This step was achieved in 2020 and our results were published in Clinical Genetics. Indeed, a homozygous stop gain mutation in the BOD1 gene (p.R151*) was identified and was shown to be involved in the disease observed in this family. BOD1 is a crucial protein that inhibits the PP2A-B56 phosphatase at the kinetochore, which regulates the recruitment of various proteins (such as PLK1: Polo like Kinase 1 ) to ensure proper chromosome orientation during mitosis (Porter et al. 2013). Additionally, BOD1 is a part of a cytosolic variant of the SET1B/COMPASS complex, which affects the expression of genes related to fatty acid metabolism (Wang et al. 2017). Studies in Drosophila have shown that BOD1 depletion in neurons causes synapse morphological abnormalities and learning defects (Esmaeeli-Nieh et al. 2016). Moreover, BOD1 was described to be responsible for ataxic-like behaviors in mice with conditional in what tissue? Knock-Out (KO) of exon 2 of this gene in the lobes IV-V of the cerebellum  (Liu et al. 2022). On another note, a homozygous nonsense mutation in BOD1 gene (p.R112*) was identified in two related Iranian females, who were diagnosed with moderate form of ID (Intellectual Disability) and primary/secondary amenorrhea (Esmaeeli-Nieh et al. 2016).B) Secondly, we aimed to study the effect of the p.R151* mutation in BOD1 gene on protein expression. To achieve this, we used the CRISPR-Cas9 genome editing technique to create a knock-in (KI) of the mutation in HEK293T cells. We then analyzed the effect of this mutation on the expression of Bod1 protein using Western blot technique. Furthermore, we wanted to investigate the physiological and developmental function of the BOD1 gene. For this purpose, we have generated a conditional knock-out cKO mouse model.

What? BENEVOL on Thursday and Friday, 21 and 22 November: the congress will bring together researchers working in software engineering, evolution, and maintenance. This year, we will have two keynotes: one by Prof. Andy Zaidman from TU Delft and one by Prof. Sonia Haiduc from Florida State University. IMPACT! day on November 20: as a PhD student and/or researcher, you can join us to learn to communicate what you bring to the table efficiently thanks to the tried and tested Value Proposition canvas and exchange with practitioners, who will expose the challenges they encounter daily. The IMPACT! day initiative is supported by the GRASCOMP doctoral school, and participants will receive a certificate. As a software development professional, you can join us on Wednesday afternoon, November 20, as a guest from the corporate world to share your current challenges and connect with researchers working to advance software development and maintenance practices (please do not hesitate to contact us at snail.info@unamur.be if you would like to participate in the introductory panel of guests from the professional world and/or at the World Café). When? Wednesday 20 (IMPACT Day!) Thursday 21 - Friday 22 November 2024 (BENEVOL Research Congress) Organizers Xavier Devroey, Gilles Perrouin, Benoît Vanderose, Anthony Cleve, Babette Di Guardia, Amélie Notaro, Sophie Panarotto, Alix Decrop, Tom Mens Where? TRAKK, Namur creative hub (Journée IMPACT!) S09, Faculty of Sciences, University of Namur, Belgium (BENEVOL Research Congress) More information

L’Université de Stanford a publié un classement prestigieux qui met en lumière les chercheurs les plus influents dans un large éventail de domaines scientifiques. Cette liste, établie sur base de critères bibliographiques, vise à fournir un moyen normalisé d'identifier les leaders scientifiques mondiaux. Il s’agit d’un critère parmi d’autres permettant d’évaluer la qualité de la recherche scientifique. Douze chercheurs de l’Université de Namur en font partie !