Résultats de recherche

Keynote speaker | Murielle Ålund - Uppsala UniversityShort talks - Poster and pannel sessions - Networking eventSoumettez un abstract et gagnez l'un des prix !Plus d'infos et inscriptions sur le site Women and Girls in science

Charting the DNA methylome landscape in cancer, chronic disease and phenotype Abstract: Our team has developed some of the first pipelines for genome-scale DNA methylation analysis. Our work has revealed aberrant methylation and expression patterns in several cancer types and revealed new mechanism of epigenetic regulation in cancer cells. We are now applying cutting-edge whole genome scale DNA methylation analysis in tissues as well as well as in cell free DNA (epigenetic liquid biopsy) and epigenetic editing platforms to investigate clinically relevant biomedical questions in cancer (for example, methylation map of colorectal, prostate, lung cancer and pancreatic cancer patients). Our work in epigenetic editing has implication in revealing causal function and new epigenetic regulation. In this talk, I will present the key findings from some of our works over the years and also elaborate on some recent and future directions in understanding the role of DNA methylation events in cancer metastasis, early detection, and treatment monitoring in solid cancers and also in chronic diseases and phenotype. More information on the ILEE website

Une formation pratique en chimie quantique computationnelle a été organisée du 26 au 30 mai 2025 dans le cadre d’une collaboration ERASMUS+ entre l’Université de Sfax et l’Université de Namur. Cette formation interuniversitaire destinée aux doctorants en chimie et physique de l’Université tunisienne a rassemblé plus de 20 étudiants. 

High-Sensitivity Birefringence Mapping Using Near-Circularly Polarized Light I will describe several techniques for mapping a two-dimensional birefringence distribution, which can be classified according to the optical schemes and principles of work:Illumination geometry (transmitted light/reflected light)Image acquisition (sequential acquisition/simultaneous acquisition)Polarization control (electrically controlled variable retardance/mechanical rotation).This classification facilitates a comparative analysis of the capabilities and limitations in these methods for birefringence characterization. Polychromatic polarizing microscopy (PPM) provides unique capabilities to alternative methods. It leverages vector interference to generate vivid, full-spectrum colors at extremely low retardances, down to < 10 nm. PPM is a significant departure from conventional polarizing microscopes that rely on Newton interference, which requires retardances above 400 nm for color formation. Furthermore, PPM's color output directly reflects the orientation of the birefringent material, a feature absent in conventional microscopy where color is solely determined by retardance.Joint seminar of ILEE & NISM!Le séminaire est accessible à des personnes externes également, pas besoin de s'inscrire. Plus d'infos

Abstract Radiotherapy is a cornerstone of cancer treatment and is currently administered to approximately half of all cancer patients. However, the cytotoxic effects of ionizing radiation on normal tissues represent a major limitation, as they restrict the dose that can be safely delivered to patients and, consequently, reduce the likelihood of effective tumor control. In this context, delivering radiation at ultra-high dose rates (UHDR, > 40 Gy/s) is gaining increasing attention due to its potential to spare healthy tissues surrounding the tumor and to prevent radiation-induced side effects, as compared to conventional dose rates (CONV, on the order of Gy/min).The mechanism underlying this protective effect—termed the FLASH effect—remains elusive, driving intensive research to elucidate the biological processes triggered by this type of irradiation.In vitro models offer a valuable tool to support this research, allowing for the efficient screening of various beam parameters and biological responses in a time- and cost-effective manner. In this study, multicellular tumor spheroids and normal cells were exposed to proton irradiation at UHDR to evaluate its effectiveness in controlling tumor growth and its cytotoxic impact on healthy tissues, respectively.We report that UHDR and CONV irradiation induced a comparable growth delay in 3D tumor spheroids, suggesting similar efficacy in tumor control. In normal cells, both dose rates induced similar levels of senescence; however, UHDR irradiation led to lower apoptosis induction at clinically relevant doses and early time points post-irradiation.Taken together, these findings further highlight the potential of UHDR irradiation to modulate the response of normal tissues while maintaining comparable tumor control.JuryProf. Thomas BALLIGAND (UNamur), PrésidentProf. Stéphane LUCAS (UNamur), SecrétaireProf. Carine MICHIELS (UNamur)Dr Sébastien PENNINCKX (Hôpital Universitaire de Bruxelles)Prof. Cristian FERNANDEZ (Université de Bern)Dr Rudi LABARBE (IBA)

Abstract Due to their unique chemical, physical and photophysical properties, organoboron compounds and in particular triarylboranes play a central role in chemistry and in catalysis. Trivalent neutral boron Lewis acids, which are planar trigonal species, have been shown to exhibit enhanced Lewis acidity and electrophilicities when constrained in a pyramidal trigonal environment. Within the context of the emerging area of geometrically constrained main-group elements, the fundamental experimental and computational investigations of the impact of structural deformation on the physicochemical properties and reactivity of borane derivatives is of interest. This thesis will explore successively the development of geometrically constrained intramolecular FLP and of cationic boron Lewis superacid based on the aza-boratriptycene scaffold, then the synthesis of pyramidalyzed electron-deficient borenium cation with tethered pyridine and NHC ligands embedded in the triptycene scaffold and will finally focus on chiral borenium cations as new Lewis acids. A collaborative work dealing with the combination of the strong 9-sulfonium-10-boratriptycene with hindered Lewis bases is finally performed for developing latent FLP. This work deepens our understanding of the synthesis of constrained boron Lewis acids species, a key step to develop new pyramidal boron Lewis superacids, deblocking new kinds of reactivity in main-group chemistry. For instance, electrophilic Csp2–H borylation reactions of electron-poor aromatics were observed, new unusual binding mode at weakly coordinating anions were discovered and encouraging steps were initiated for reaching new chiral boron-based Lewis acids, opening the path toward new horizons in main-group chemistry.JuryProf. Benoît CHAMPAGNE (UNamur), PrésidentProf. Guillaume BERIONNI (UNamur), SecrétaireProf. Olivier CHUZEL (Aix-Marseille Université)Prof. Raphaël ROBIETTE (UCLouvain)Prof. Stéphane VINCENT (UNamur)

Entre 2020 et 2025, la chercheuse Julie Duchêne a mené dans le cadre de sa thèse de doctorat en histoire, une enquête inédite mêlant histoire et biologie pour retracer la cohabitation entre humains et loups en Wallonie et au Luxembourg, du 18e au début du 20e siècle. Grâce à une approche interdisciplinaire novatrice, incluant l’analyse ADN de spécimens naturalisés du 19e siècle, son travail éclaire les mécanismes ayant conduit à l’extinction locale de l’espèce. Un travail de recherche rendu possible grâce au soutien de nombreux partenaires scientifiques et culturels.

Le Professeur Eli Thoré et Justine Bélik viennent d’être récompensés par le Fonds Adrien Bauchau (FAB).  Créé à la mémoire du fondateur du Département de biologie de l'UNamur, le FAB promeut, depuis 1989, l’excellence de la formation et de la recherche dans le domaine des sciences de la vie.

Une recherche peu banale a récemment mobilisé des équipes du Département de biologie de l’UNamur. Des analyses génétiques réalisées par l’Unité de Recherche en Biologie Environnementale et évolutive (URBE) ont en effet pu confirmer le statut de protection d’un troupeau de mouflons sauvages installé à Gesves, et ainsi souligner l’importance de leur sauvetage. 

En mai 2025, le Département de physique recevait des visiteurs particuliers : deux namurois, Serge Mathot et François Briard, alumni de l’UNamur et membres du CERN.  Plusieurs activités étaient au programme, allant de la visite de l’accélérateur à particules, en passant par la vulgarisation scientifique et les séminaires thématiques notamment en sciences du patrimoine.  Objectif ? Identifier les domaines ou activités dans lesquels l’UNamur et le CERN pourraient renforcer leur collaboration.

La découverte du nucléaire a marqué un tournant dans l’histoire de l’humanité. Aujourd’hui, parallèlement aux débats qui concernent sa place dans la production d’énergie et ses potentialités destructrices, le nucléaire continue d’être utilisé dans de multiples domaines, comme la recherche médicale et les thérapies contre le cancer. À l’UNamur, le nucléaire est ainsi au cœur du travail de biologistes, physiciens ou encore historiens de l’art.

En 2025, deux produits emblématiques de Wallonie – le Miel wallon et le Boudin blanc de Liège – ont obtenu la précieuse reconnaissance européenne IGP. Derrière cette réussite se cache le projet AgriLabel, auquel l’UNamur contribue depuis plus de dix ans. Aux côtés des producteurs, des spécialistes et des institutions publiques, notre Département d’Histoire a joué un rôle déterminant : démontrer, par les sources et par l’analyse scientifique, le lien intime entre ces produits et leur terroir. Un projet au cœur d’enjeux économiques, identitaires, culturels et scientifiques.