Résultats de recherche

Fin novembre, l’entreprise Cellistic®, basée à Mont-Saint-Guibert, a fait don à l’UNamur d’équipements dont elle n’avait plus usage. En permettant à l’université de donner une seconde vie à ce matériel, Cellistic accomplit un geste important au bénéfice du développement de la recherche universitaire.  

Depuis septembre 2023, Marc Hennequart, professeur en biochimie et biologie cellulaire à l’UNamur, mène des recherches novatrices sur le cancer du pancréas. Son équipe, basée à la Faculté de médecine et à l’Institut Narilis, étudie les étapes précoces de l’oncogenèse (processus de transformation d’une cellule normale en une cellule cancéreuse) pour mieux comprendre les changements métaboliques à l’origine de ce cancer particulièrement agressif.

Thematic sessionsThe day will be organized in two thematic sessions:Cancer metabolismNew advances in cancer therapyInvited speakersProf. Rebecca FITZGERALD, Early Cancer Institute, University of Cambridge, UKDr. Sébastien DUTERTRE, IBMM, University of Montpellier, FranceProf. Sarah-Maria FENDT, Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven, BelgiumDr. Arnaud BLOMME, Laboratory of Metabolic Regulation, GIGA Institute, University of Liège, Belgium Call for communicationsYoung researchers are invited to submit abstracts for oral communications and posters. All topics related to the field of cancer research are welcome. The deadline for abstract submission is April 1, 2025. Organizing committeeProf. Jean-Pierre Gillet - UNamur, NARILIS, Laboratory of Molecular Cancer BiologyProf. Marc Hennequart - UNamur, NARILIS, Laboratory of Cancer metabolismProf. Marielle Boonen - UNamur, NARILIS, Laboratory of Intracellular Trafficking BiologyProf. Benjamin Beck - ULB, IRIBHMProf. Lionel D'Hondt - CHU UCL Namur, Department of Oncology More info

L’espace est devenu le lieu d’importants enjeux économiques et stratégiques. Membre de l’Alliance européenne UNIVERSEH, l’UNamur explore cette thématique spatiale dans ses différents départements, de la physique à la géologie, en passant par les mathématiques, l’informatique ou la philosophie. Sans oublier de s’adresser au grand public, que les étoiles font toujours rêver...

Keynote speaker | Murielle Ålund - Uppsala UniversityShort talks - Poster and pannel sessions - Networking eventSoumettez un abstract et gagnez l'un des prix !Plus d'infos et inscriptions sur le site Women and Girls in science

Charting the DNA methylome landscape in cancer, chronic disease and phenotype Abstract: Our team has developed some of the first pipelines for genome-scale DNA methylation analysis. Our work has revealed aberrant methylation and expression patterns in several cancer types and revealed new mechanism of epigenetic regulation in cancer cells. We are now applying cutting-edge whole genome scale DNA methylation analysis in tissues as well as well as in cell free DNA (epigenetic liquid biopsy) and epigenetic editing platforms to investigate clinically relevant biomedical questions in cancer (for example, methylation map of colorectal, prostate, lung cancer and pancreatic cancer patients). Our work in epigenetic editing has implication in revealing causal function and new epigenetic regulation. In this talk, I will present the key findings from some of our works over the years and also elaborate on some recent and future directions in understanding the role of DNA methylation events in cancer metastasis, early detection, and treatment monitoring in solid cancers and also in chronic diseases and phenotype. More information on the ILEE website

Abstract Radiotherapy is a cornerstone of cancer treatment and is currently administered to approximately half of all cancer patients. However, the cytotoxic effects of ionizing radiation on normal tissues represent a major limitation, as they restrict the dose that can be safely delivered to patients and, consequently, reduce the likelihood of effective tumor control. In this context, delivering radiation at ultra-high dose rates (UHDR, > 40 Gy/s) is gaining increasing attention due to its potential to spare healthy tissues surrounding the tumor and to prevent radiation-induced side effects, as compared to conventional dose rates (CONV, on the order of Gy/min).The mechanism underlying this protective effect—termed the FLASH effect—remains elusive, driving intensive research to elucidate the biological processes triggered by this type of irradiation.In vitro models offer a valuable tool to support this research, allowing for the efficient screening of various beam parameters and biological responses in a time- and cost-effective manner. In this study, multicellular tumor spheroids and normal cells were exposed to proton irradiation at UHDR to evaluate its effectiveness in controlling tumor growth and its cytotoxic impact on healthy tissues, respectively.We report that UHDR and CONV irradiation induced a comparable growth delay in 3D tumor spheroids, suggesting similar efficacy in tumor control. In normal cells, both dose rates induced similar levels of senescence; however, UHDR irradiation led to lower apoptosis induction at clinically relevant doses and early time points post-irradiation.Taken together, these findings further highlight the potential of UHDR irradiation to modulate the response of normal tissues while maintaining comparable tumor control.JuryProf. Thomas BALLIGAND (UNamur), PrésidentProf. Stéphane LUCAS (UNamur), SecrétaireProf. Carine MICHIELS (UNamur)Dr Sébastien PENNINCKX (Hôpital Universitaire de Bruxelles)Prof. Cristian FERNANDEZ (Université de Bern)Dr Rudi LABARBE (IBA)

La deadline d'inscription et de soumission pour les abstracts : 20 août 2025.  Plus d'infos sur le site internet de l'Institut NARILIS

Détecter une panne avant qu’elle ne survienne : c’est l’objectif de la recherche menée par Antoine Hubermont, doctorant à l’UNamur. Ce projet baptisé Monsater est financé par le SPW Recherche dans le cadre du programme Win4Doc en collaboration avec l’entreprise spatiale Telespazio Belgium. Il s’inscrit au cœur d’un enjeu stratégique : garantir la fiabilité de systèmes complexes, notamment dans le domaine spatial.