Radiotherapy traditionally uses an X-ray beam to target the tumor, but today, researchers are increasingly turning their attention to protons.
“UNamur has the only proton irradiator in the Wallonia-Brussels Federation, which allows us to study their advantages over X-rays,” notes Carine Michiels.
Read our previous article on this topic: ALTAïS – Penetrating the depths of matter to address current challenges
“Protons have a ballistic advantage,” explains Anne-Catherine Heuskin. “When you target a tumor with X-rays, some of the radiation is absorbed and some passes through to the other side. By irradiating upstream, you also affect the downstream area. But the goal is to spare healthy tissue as much as possible: in breast cancer, for example, we try to avoid irradiating the heart.”
Because they interact differently with matter, protons deposit a small amount of energy continuously as they travel.
“On the other hand, when they have only a few centimeters or millimeters left to travel, they release all their energy at once,” continues Anne-Catherine Heuskin. “Whatever lies downstream is then spared.”
Proton therapy is particularly promising for treating pediatric cancers—that is, for patients who still have a very long life expectancy and are therefore at greater risk of experiencing the long-term effects of radiation on their healthy tissues.
In addition to these external radiation therapy techniques, it is also possible to treat tumors using internal radiation therapy,
“by attaching a radioactive atom to a ‘carrier,’ such as gold nanoparticles, which will transport this atom to the tumor via the bloodstream,” explains Carine Michiels.
This technique maximizes the effect on cancer cells while sparing normal cells as much as possible.
“Over the past 5 to 10 years, the major breakthrough in cancer treatment has been immunotherapy,” she continues. “But we still don’t understand why some patients respond to it and others don’t. One hypothesis is that we need to boost the cancer cells so that they are recognized by the immune system. And this is where radiation therapy has a huge role to play, because by damaging the cancer cells, it helps boost the immune response. The combination of radiation therapy and immunotherapy is therefore set to play a leading role.”