The study of Brucella is one of the areas of microbiology in which UNamur research teams have specialised for more than twenty years. This pathogenic bacteria infects livestock, causing Brucellosis, a disease that can be transmitted to humans through the consumption of unpasteurised dairy products, contact with infected animal tissue or inhalation. It is one of the most widespread zoonoses in the world.

A catalogue of weaknesses

Over the years of research, the team led by Professor Xavier De Bolle, Professor in the Department of Biology, member of the Microorganism Biology Research Unit (URBM) at the University of Namur and investigator at the WEL Research Institute, has been able to establish a kind of “catalogue” of Brucella's weaknesses. 

There are millions of species of bacteria.  It is therefore impossible to study them on a case-by-case basis.  However, they have similar behaviours and functions, which is why a specific bacterium is considered the model: Escherichia coli (or E. coli), an intestinal bacteria found in warm-blooded organisms.  Discovered in 1885, it has been the subject of numerous studies and has therefore become a reference in scientific literature. 

A bacterium such as E. coli or Brucella is like an onion with only two layers (inner and outer membrane) and a central element (the cytoplasm) in which the organism produces everything it needs. It also exports elements to the outside, particularly lipids.  However, these processes are still poorly understood, even for E. coli. Nevertheless, they represent an interesting avenue to explore to reach the heart of the pathogenic bacteria.

This provides valuable information about a new weakness in the pathogen and therefore provides information on how to combat it more effectively.

• Adélie Lannoy (currently post-doc in Toulouse) and Xavier De Bolle (URBM, UNamur – Belgium)
• Marc Dieu and Patsy Renard (UNamur, URBC - Belgium)
• Antonia García Fernández (Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU – Spain)
• Raquel Condez-Alvarez (Department of Microbiology and Parasitology, Instituto de Investigación Sanitaria de Navarra (IdiSNA)University of Navarra – Spain)

The researchers would like to thank the FNRS and the WEL Research Institute for their support in this research. They would also like to thank the ‘Mass Spectrometry – MaSUN’ platform and the ‘Level 3 Biosafety Laboratory – BL3’ technology platform at UNamur for their cutting-edge equipment and expertise.

This work illustrates the cutting-edge expertise developed at UNamur in the field of molecular microbiology, an area in which UNamur has decided to invest by organising a master's degree in molecular microbiology since September 2019. This is a unique master's degree in Europe, taught entirely in English and rooted in research.

• New clues to break through Brucella's armour (02/27/2023) - https://unamur.be/fr/newsroom/de-nouveaux-indices-pour-percer-larmure-de-brucella
• Alison Forrester and Xavier De Bolle awarded grants from the latest FRFS-Welbio call for projects (07/23/2024) - https://unamur.be/fr/newsroom/laureats-dernier-appel-projets-frfs-welbio

Four researchers obtained a mandat d'aspirant enabling them to start doctoral research:

• Ludovic DUBOIS and Niccolò PARDINI from the Faculty of Philosophy and Letters,
• Jordan ABRAS from the Faculty of Economics Management Communication sciencesPo (EMCP)
• Noah DEVEAUX from the Faculty of Science.

Success is also on the cards for the postdoctoral researchers, nine of whom have been awarded a research fellowship for 3 years.

• Audrey LEPRINCE, Ciska DE RUYVER, Dmytro STRILETS and Cinzia TOMASELLI from the Faculty of Sciences
• Nicolas MICHEL, Sébastien VANDENITTE and Manon HOUTART from the Faculty of Philosophy and Letters
• Pierre-Yves HUREL and Sebastian RONDEROS from the Faculty of Economics Management Communication sciencesPo (EMCP).

In addition, two new qualified researchers join our university.

• Marie DELABY in the Biology Department of the Faculty of Science
• Matthieu PIGNOT in the History Department of the Faculty of Philosophy and Letters

Three Namur researchers have also obtained funding from the Télévie call.

• Marc HENNEQUART for research aimed at highlighting new metabolic biomarkers for better detection of pancreatic cancer
• Carine MICHIELS for research into the resistance of glioblastoma to radiotherapy combined with chemotherapy
• Anne-Catherine HEUSKIN for research into understanding the reprogramming of macrophage immune cells in the formation of the tumor microenvironment.

Frédéric SILVESTRE (Faculty of Science, Department of Biology, URBE) has also been awarded funding for a FNRS-FRQ collaborative project with ULiège and Quebec teams from the Université de Montréal and the Université du Québec à Montréal. The aims of this project are to develop a new method of age determination based on molecular modifications (epigenetic clock) in beluga whales (Delphinapterus leucas) from the St. Lawrence estuary in Quebec, and to understand the role of age on contaminant accumulation as well as on their stress levels and health status. This will enable better decisions to be made to improve the recovery of this endangered population. As part of this project, two doctoral theses (one in Namur and one in Montreal) are open. Candidates must be biologists (or degree deemed equivalent) with an interest in conservation and ecotoxicology issues, and with experience in molecular biology (omics) and bioinformatics.

Congratulations to them!

In recent months, the commune of Gesves, in the province of Namur, was confronted with the presence of a herd of mouflons, wild sheep recognizable by their impressive spiral horns. At the origin of this one: a male and a female probably escaped from a private hunt, who settled and reproduced in the meadows of this rural commune in 2019, until forming a full-fledged herd of 17 individuals in 2024.

While these sheep won the affection of the locals, local farmers deplored the damage caused to their crops. Their complaints led in August 2024 to a destruction authorization from the Department of Nature and Forestry (DNF). Several individuals were also shot during the hunting season.

Touched by the fate of these animals, a handful of local residents have been carrying out a veritable rescue operation for the seven mouflons still present on the meadows since January. The maneuver promised to be complex, to say the least: on the one hand, it was necessary to gather the official authorizations required to capture and transport the mouflons to a suitable location, and on the other hand, to set up an infrastructure to capture them.

Alongside this initiative, the mobilized local residents - including Nathalie Kirschvink, a veterinarian and professor at UNamur's Faculty of Medicine - called on the expertise of the laboratories of UNamur's Environmental and Evolutionary Biology Research Unit (URBE) to clarify a crucial question: the origin of the mouflons. Indeed, in our regions, mouflons are considered game and therefore huntable, while mouflons from certain lineages benefit from protection.

Nathalie Kirschvink therefore entrusted fresh samples made up of hair and dung to Alice Dennis, professor and researcher at the URBE. Sequencing the DNA contained in these samples enabled Alice Dennis and technician Jérôme Lambert to identify kinship links between the Gesves bighorn sheep and those from a Corsican lineage, whose genome had already been described in the scientific literature.

This expertise lies at the heart of URBE's research, which uses the tools of molecular ecology to study both the physiology of organisms (such as snails for Alice Dennis) and their interactions with their environment. The methodology used can be applied to very concrete, local cases, such as that of the Gesves bighorn sheep, but, more broadly, serve to better understand genetic diversity between species with a view to safeguarding biodiversity.

The FAB's regular actions in the Belgian university context include awarding grants, prizes and subsidies, organizing a chair, contributing to the organization of colloquia, doctoral schools or study days. It collaborates with a network of Belgian and foreign partners: individuals, public and private associations, institutions and companies.

In consultation with the Department of Biology at the University of Namur, the Fonds Adrien Bauchau has awarded financial assistance for the first time in the amount of 25,000 euros to support a young professor or post-doctoral fellow in biology at the institution in the early stages of their professional career.

In May 2025, the FAB Board of Directors awarded this grant to Professor Eli Thoré, an academic in the Unité de Recherche Environnementale et Evolutive (URBE), for the development of his work.

The 2025 Scholarship has been awarded to Justine Bélik, whose thesis promoter is Professor Frédéric Silvestre, for her participation in the 3rd international EPIMAR 2025 "Epigenetics in marine and aquatic research" congress, organized at the end of May 2025 in Barcelona, Spain.

The grant is intended for a young researcher to enable his/her participation in a conference abroad. The amount awarded depends on the cost of this participation; it can be up to €750.

The Biology Department conducts cutting-edge international scientific research. This is divided between 5 research units tackling a variety of themes: cell biology (URBC), microbiology (URBM) or methodology and didactics (UMDB). The two award-winning researchers are part of the Environmental and Evolutionary Biology Research Unit (URBE) and are members of the Institute of Life, Earth and Environment (ILEE), which is committed to addressing pressing environmental issues.

Professor Frédéric Silvestre, Justine Bélik's thesis sponsor, heads the Laboratory of Evolutionary and Adaptive Physiology (LEAP). This laboratory studies the impacts of environmental change on aquatic organisms at different levels, from the perspective of integrative physiology.

Professor Eli Thoré heads the Adaptive Biodynamics Laboratory (LAB). He uses an integrative approach to understand how animals respond to environmental changes, particularly those induced by human activity in space and time.