Learning outcomes

At the end of the teaching activities, the student will have acquired the different notions that will allow him/her to

  • make links between the structure of compounds and UV, IR and NMR spectral properties;
  • make links between the structure of compounds and potential non-covalent bonds;
  • make the links between the structure of compounds and acid/base properties;
  • make the links between the structure of the compounds and the solubility properties;
  • make the links between the structure of the compounds and the lipophilic properties;
  • understand certain descriptors such as log P, PSA and certain rules of thumb (Lipinski);
  • to make the links between the structure of compounds and the stability of molecules;
  • to make the lings between the structure and the pharmacokinetics.

Goals

The objective of this course is to associate, for a given molecule, its chemical structure with its properties and in particular, spectral, physicochemical (solubility, lipophilicity), acid/base, non-covalent interactions, stabilities and pharmacokinetics properties.

Content

Part I: Molecular structure

  • Functional groups and heterocycles
  • Chemical structure: isomerism and equilibrium
  • Non-covalent interactions

Part II: Properties

  • spectral
  • acid/base properties
  • lipophilicity
  • pharmacokinetics

Table of contents

Part I: Molecular structure

  • Functional groups and heterocycles
  • Chemical structure: isomerism and equilibrium
  • Non-covalent interactions 

Part II: Properties

  • spectral 
  • acid/base properties 
  • lipophilicity
  • pharmacokinetics

Exercices

Tutorial sessions are devoted to solving and explaining exercises and problems from the various chapters of the course. 

Teaching methods

Slides, multi-media projections and the blackboard are used during the theoretical course, which is illustrated by a few numerical examples.

Tutorial sessions are devoted to solving and explaining exercises from the various chapters of the course.

Assessment method

The exam is written. It will include theory and exercise questions.

 

Sources, references and any support material

Course slides and TD syllabus are available on WebCampus. 

Language of instruction

French
Training Study programme Block Credits Mandatory
Bachelor in Pharmacy Standard 0 4
Bachelor in Pharmacy Standard 2 4