Public defense of doctoral thesis in Physical Sciences - Andrea Scarmelotto
Abstract
Radiotherapy is a cornerstone of cancer treatment and is currently administered to approximately half of all cancer patients. However, the cytotoxic effects of ionizing radiation on normal tissues represent a major limitation, as they restrict the dose that can be safely delivered to patients and, consequently, reduce the likelihood of effective tumor control. In this context, delivering radiation at ultra-high dose rates (UHDR, > 40 Gy/s) is gaining increasing attention due to its potential to spare healthy tissues surrounding the tumor and to prevent radiation-induced side effects, as compared to conventional dose rates (CONV, on the order of Gy/min).The mechanism underlying this protective effect-termed the FLASH effect-remains elusive, driving intensive research to elucidate the biological processes triggered by this type of irradiation.In vitro models offer a valuable tool to support this research, allowing for the efficient screening of various beam parameters and biological responses in a time- and cost-effective manner. In this study, multicellular tumor spheroids and normal cells were exposed to proton irradiation at UHDR to evaluate its efficacy in controlling tumor growth and its cytotoxic impact on healthy tissues, respectively.We report that UHDR and CONV irradiation induced a comparable growth delay in 3D tumor spheroids, suggesting similar efficacy in tumor control. In normal cells, both dose rates induced similar levels of senescence; however, UHDR irradiation led to lower apoptosis induction at clinically relevant doses and early time points post-irradiation.Taken together, these findings further highlight the potential of UHDR irradiation to modulate the response of normal tissues while maintaining comparable tumor control.JuryProf. Thomas BALLIGAND (UNamur), PresidentProf. Stéphane LUCAS (UNamur), SecretaryProf. Carine MICHIELS (UNamur)Dr Sébastien PENNINCKX (Hôpital Universitaire de Bruxelles)Prof. Cristian FERNANDEZ (University of Bern)Dr Rudi LABARBE (IBA)
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MGERC European Conference (Main-Group Elements Reactivity Conference)
Welcome to the 1ʳᵉ MG-ERC conference
This conference, linked to the research themes of the Chemistry Department, aims to bring together around 100 researchers working in the fields of heteroatom chemistry, coordination chemistry, catalysis, and inorganic chemistry. It represents a real novelty in Belgium in terms of the areas covered, and will enable participants to discover new concepts, ideas and trends in these recent areas of research in chemistry.
Here is the list of speakers, who are world experts in their fieldsDr. Daniël Broere (Utrecht University, Netherlands)Prof. Agnieszka Nowak-Król (Universität Würzburg, Germany)Dr. Antoine Simonneau (Université Paul-Sabatier, Toulouse, France)Prof. Dr. Sebastian Riedel (Freie Universität, Berlin, Germany)Dr. Arnaud Voituriez (Université Paris-Saclay, France)Prof. Dr. Alessandro Bismuto (Universität Bonn, Germany)Dr. Christian Hering-Junghans (Leibniz-Institut für Katalyse, Germany)Prof. Connie Lu (Universität Bonn, Germany)Prof. Simon Aldridge (University of Oxford, UK)Dr. Ghenwa Bouhadir (Université Paul-Sabatier, Toulouse, France)Prof. Dr. Viktoria Däschlein (Universität Bonn, Germany)Prof. Viktoria Däschlein-Gessner (Ruhr-University of Bochum, Germany)Dr. Jennifer A. Garden (University of Edinburgh, UK)Prof. Muriel Hissler (Université de Rennes, France)Prof. Jean-François Paquin (Université de Laval, Canada)
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Flamure Ibrahimi has been awarded the 2026 ServCollab Scholarship, an international recognition of excellence in doctoral research!
Flamure Ibrahimi is a Ph.D. student in service and marketing management at the NaDI-CeRCLe Research Center at the University of Namur (Belgium) within the EMCP Faculty, under the supervision of Prof. Dr. Wafa Hammedi (University of Namur) and Prof. Dr. Linda Alkire (Texas State University). She has just been awarded the prestigious ServCollab Scholarship 2026, an international distinction that recognizes and supports doctoral students whose work falls within the field of Transformative Service Research (TSR)—doctoral projects with high impact on society and humanity.
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At the Heart of Nuclear Power
The discovery of nuclear energy marked a turning point in human history. Today, alongside debates about its role in energy production and its destructive potential, nuclear energy continues to be used in a wide range of fields, such as medical research and cancer therapies. At UNamur, nuclear energy is thus at the heart of the work of biologists, physicists, and art historians.
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Win4Doc | 10 years of UNamur - STÛV collaboration: a lever for innovation, attractiveness and excellence
The University of Namur and STÛV, a Namur-based company specializing in wood and pellet heating solutions, are celebrating ten years of fruitful collaboration. This partnership illustrates the importance of synergies between academia and industry to improve competitiveness and meet environmental challenges.
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Researchers from Namur Achieve Great Success in the F.R.S.-FNRS’s 2026 “Grants and Research Awards” and “Télévie” Calls
On June 23, 2026, the F.R.S.-FNRS published the list of recipients of various doctoral and postdoctoral fellowships and Télévie projects (cancer-focused research). Among them, numerous researchers from UNamur received funding.
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Global experts in electroluminescence and optoelectronics gather at UNamur
Recognized as a leading research conference in the field of organic electroluminescence and light-emitting devices, the ICEL conferences have generally been held every two years since their inception in Fukuoka, Japan, in 1997, by Professor Tetsuo Tsutsui. A look back at ICEL2026, the 15th conference of its kind, held at UNamur.
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Public Defense of a Doctoral Dissertation in Computer Science - Antoine Hubermont
Abstract
Predictive maintenance (PdM) is increasingly being used to improve system reliability, reduce downtime, and optimize operating costs in complex industrial environments through anomaly detection. As industrial systems become more complex, with components interacting with one another and monitored by ever-expanding sensor networks, anomaly detection faces new methodological challenges. In particular, there is a gap in the literature regarding anomaly detection using traditional machine learning (ML) methods based on a Single Label Classification (SLC) approach, which is unsuitable when multiple failures can occur simultaneously.Traditional anomaly detection approaches based on ML methods using an SLC formulation assume that each observation belongs to a single anomaly category. This assumption does not hold when multiple failures occur simultaneously on the same equipment, resulting in a loss of information. We begin by illustrating this limitation through a concrete example showing that using an SLC approach instead of a multi-label formulation degrades the classification of simultaneous anomalies. To address this issue, anomaly detection is reformulated as a Multi-Label Classification (MLC) problem, enabling the detection of multiple failures within a single time step. Following this reformulation, the issue of selecting multi-label classifiers suited to the context of Predictive Maintenance (PdM) must be examined. The general conclusion from the literature is that the performance of classifiers depends heavily on the context and that while there are many detection methods, none is universally dominant. Although in-depth comparative studies exist in the field of MLC, datasets from complex systems are absent from these comparisons, even though they exhibit specific characteristics such as multivariate time-series structures, significant label imbalance, and complex interactions between components.To address this gap, a structured and reproducible evaluation protocol is proposed to evaluate eight state-of-the-art ML methods in an MLC framework across three public industrial datasets. The results confirm that the performance of classifiers depends heavily on the characteristics of the dataset and that no single method consistently outperforms others across all scenarios. However, conducting this type of comparison for each new industrial context is costly in terms of time, computational resources, and data requirements, which limits its feasibility for real-world industrial deployment. The thesis also addresses this issue through dimensionality reduction and variable selection methods. PM systems generate large multivariate datasets in which only a subset of the variables is actually relevant for anomaly detection. A self-adaptive evolutionary strategy is proposed to perform wrapper-style variable selection and obtain a subset containing only the most informative variables. Experimental results show that reducing the variable space improves computational efficiency and, in most cases, anomaly prediction performance. A comparison of the proposed method with state-of-the-art metaheuristic approaches on three PdM datasets and five anomaly detection methods confirms its competitiveness in terms of predictive performance and the optimal size of the selected feature subset. Finally, feature space reduction not only optimizes the resources required for detection but also reduces the number of signals that technicians must analyze during root cause investigations. This simplification aims to strengthen confidence in the system. Finally, the thesis addresses the practical aspects of deploying detection methods in complex systems. Among these, there is a lack of trust and transparency among maintenance technicians and decision-makers. An analysis of the interpretability and robustness of anomaly detection methods is provided to directly contribute to their deployment in real-world conditions. First, the proposed variable selection strategy is evaluated on a public PdM dataset using SHAP-based explanations to verify the consistency between the selected variables and those identified as the most important by tools dedicated to interpretability. The results show that the selected variables are consistent with those identified as the most important by these tools. Furthermore, visual analysis of the most influential variables reveals that anomalies are associated with a limited and well-defined subset of sensor signals, which helps improve transparency and strengthen confidence in automatic detection systems. At the same time, it is necessary to conduct a study of the robustness of multi-label classifiers in controlled sensor degradation scenarios, including different types of degradation and various levels of severity. The results show that the performance of classifiers can deteriorate significantly, particularly in the presence of gradual drifts. To mitigate this effect, introducing sensor degradation during training appears to be a relevant strategy. Finally, this thesis proposes a structured framework for multi-label anomaly detection in complex systems, covering classification methods, feature space optimization, interpretability, and robustness. For each of these aspects, the thesis adopts an industrial perspective and takes into account the differences between controlled laboratory experimental conditions and the additional constraints of real-world complex environments.
The jury
Prof. Katrien Beuls - University of Namur, BelgiumProf. Elio Tuci - University of Namur, BelgiumProf. Patrick Heymans - University of Namur, BelgiumProf. Jenni Raitoharju - University of Jyväskylä, FinlandMr. Fabio Pinna - Telespazio, BelgiumMr. Vito Trianni - ISTC-CNR, Italy
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Sara Belghiti Honored by the AMS Review – The Sheth Foundation DoCCa 2026, an international recognition of excellence in doctoral research!
Sara Belghiti, a doctoral student at the University of Namur (NaDI-CeRCLe Institute) and a teaching and research assistant at the IÉSEG School of Management (France), has just been recognized by the AMS Review – Sheth Foundation Doctoral Competition for Conceptual Articles (DoCCA) 2026, one of the world’s most prestigious doctoral competitions in theoretical and conceptual marketing and management.
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Public Defense of a Doctoral Dissertation in Physical Sciences - Lucas Schoenauen
JuryProf. Carine MICHIELS (UNamur), ChairProf. Anne-Catherine HEUSKIN (UNamur), SecretaryProf. Stéphane LUCAS (UNamur)Dr. Rudi LABARBE (IBA)Prof. Joao SECO (German Cancer Research Center)Prof. Simon GALAS (University of Montpellier)AbstractRadiotherapy is one of the most widely used treatments for cancer and plays a central role in modern oncology. While technological advances have greatly improved the precision of radiation delivery, damage to healthy tissues surrounding the tumor remains a major limitation. In recent years, an innovative approach known as FLASH radiotherapy has attracted considerable attention. Unlike conventional radiotherapy, FLASH delivers the therapeutic radiation dose within a fraction of a second using ultra-high dose rates. A growing body of evidence suggests that this approach may reduce radiation-induced side effects in healthy tissues while maintaining the ability to control tumours. However, the biological mechanisms responsible for this protective effect remain poorly understood.This thesis addressed two key challenges in FLASH research. The first was the development and characterization of an experimental platform capable of generating ultra-high dose rate irradiations using the ALTAÏS accelerator at the University of Namur. This work involved designing irradiation systems, validating beam dosimetry, and establishing robust experimental protocols to ensure accurate and reproducible exposure conditions. The second objective was to introduce a new biological model for FLASH investigations: the microscopic nematode Caenorhabditis elegans (C. elegans). This organism offers several advantages, including a short life cycle, ease of handling, low cost, and the conservation of many fundamental biological processes shared with higher organisms. These characteristics make it an attractive complementary model for studying radiation responses and exploring the mechanisms underlying the FLASH effect.This thesis demonstrated the suitability of C. elegans as a model for investigating biological responses to ultra-high dose rate irradiation. Studies of developmental and neurobiological endpoints across multiple irradiation conditions highlighted its potential for mechanistic FLASH research. Together, these findings provide valuable tools to advance our understanding of the FLASH effect. More broadly, they contribute to the development of safer radiotherapy strategies aimed at reducing treatment-related toxicity and improving patient quality of life.
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Towards highly energy-efficient smart windows?
Researchers at ULiège and UNamur are developing a new electrochromic material: MoWOx.
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