Search results

AbstractNosocomial infections are a major public health problem, exacerbated by the global spread of bacterial resistance to antibiotics. Faced with this challenge, it is crucial to explore alternatives or complementary strategies to conventional treatments. Among these, the use of copper is attracting renewed interest. This metal has natural antibacterial properties that have been recognized since ancient times. It acts through multiple mechanisms such as membrane alteration, the generation of reactive oxygen species, and the denaturation of proteins and nucleic acids, leading to rapid cell death. These characteristics make it an effective biocidal agent in many contexts, particularly in hospitals.However, the selective pressure exerted by the increased presence of copper in the environment has led to the emergence of specific resistance systems in certain bacteria. These systems allow strict control of copper homeostasis by limiting its intracellular accumulation through efflux, sequestration, or oxidation mechanisms. In Caulobacter crescentus, an environmental bacterial model, copper resistance is based in particular on the Pco system. This system is composed of the PcoB protein, located in the outer membrane. Although its structure has been partially described in E. coli, its precise function remains unclear. Preliminary observations suggest that it may be involved in the export of copper from the periplasm to the outside of the cell, thus acting as a release pathway.To explore the role of PcoB in bacterial copper resistance, this study focused on the structural and functional characterization of the protein. After extraction and purification, PcoB was incorporated into artificial liposomes to develop an in vitro transport assay to assess its ability to release copper across a lipid bilayer. At the same time, a truncated mutant lacking the disordered N-terminal region was produced and subjected to the same analyses. The comparison between the complete and truncated forms aims to determine the involvement of this flexible region in the transport mechanism and stability of the protein. These approaches have laid the initial experimental foundations for studying the transport mechanism of PcoB and constitute a first step towards a detailed understanding of how the Pco system works. They also open up prospects for the development of new antibacterial strategies targeting copper management systems in bacteria.JuryProf. Johan WOUTERS (UNamur), ChairDr. Catherine MICHAUX (UNamur), SecretaryProf. Jean-Yves MATROULE (UNamur)Dr. Guillaume ROUSSEL (UCLouvain)Prof. Francesca CECCHET (UNamur)Prof. Hennie VALKENIER (ULB)

In recent years, public debate has been regularly disrupted by various attempts to distort "information." While this phenomenon is as old as information itself, digital technology, the powerful interactivity offered by online platforms, and recent developments in generative artificial intelligence have given it a whole new dimension. Manipulated online information spreads virally, reaching internet users around the world in a matter of minutes. It poses serious risks to society and threatens democracy and the rule of law. To see this, one need only recall events such as the US and French presidential elections, the Covid-19 pandemic, the war in Ukraine, the terrorist attack at the Nova festival in 2023, and the war in Gaza.  Faced with this phenomenon, actors from all sectors have been mobilizing for several years. This conference offers a legal perspective on the manipulation of online information in relation to freedom of expression and the right to information from the point of view of European law. It focuses, on the one hand, on the response of the European Union legislator to combat online disinformation and, on the other hand, on mechanisms for protecting "quality" information.Free admission.

In line with its predecessors, ICEL 2026 will provide an excellent opportunity for the intellectual and social exchanges that keep our community closely connected. It will bring together participants from all over the world involved in the research, development, and manufacturing of emissive materials. A wide array of subjects will be explored, offering a comprehensive perspective on contemporary advances in these fields. We extend a warm invitation for the dissemination of recent breakthroughs in related topics, with a particular emphasis on fostering the active participation of young and motivated researchers.We especially expect to cover the following topics:Thermally Activated Delayed Fluorescence emittersRadical emittersOrganometallic complexesPerovskitesLasingCircularly polarized luminescenceLight emission from exciplexesGreen- and biophotonicsComputational modeling of light-emitting materialsAll practical information (registration, abstract submission, and accommodation) is available on the ICEL2026 website. Access the ICEL2026 website

Our keynote speakers for 2026 are Professor Roosmarijn Vandenbroucke (Ghent University) and Professor Nelly Litvak (Eindhoven University of Technology). More information on the "Women in Science" website

The IBAF Meetings have been organized since 2003, every two years since 2008, by the Ion Beams Division of the French Vacuum Society (SFV), the oldest national vacuum society in the world, which celebrated its 80th anniversary in 2025.As in previous editions, IBAF 2026 will offer a rich and varied program with guest lectures, oral and poster presentations, and technical sessions. All this will be complemented by an industrial presence to promote exchanges between research and innovation. The conference will cover a wide range of topics, from ion beam instruments and techniques to the physics of ion-matter interactions, including the analysis and modification of materials, applications in the life sciences, earth and environmental sciences, and heritage sciences. More information on the IBAF2026 website

The F.R.S.-FNRS has just published the results of its various 2025 calls for proposals. These include the "Credits & Projects" and "WelCHANGE" calls, as well as the "FRIA" (Fund for Research Training in Industry and Agriculture) and "FRESH" (Fund for Research in the Humanities) calls, which aim to support doctoral theses. What are the results for UNamur? Twenty-eight projects have been selected, demonstrating the quality and richness of research at UNamur. 

This preregistration would result in an adjustment to the PAE without prejudice to the procedure to be followed to validate this eventual registration.

Practical information:When: Wednesday, March 11, 2026, from 8:30 a.m. to 12 p.m.Cost: FreeLanguage: FrenchAudience: 5th and 6th year secondary school studentsMeeting place: University of Namur (The exact address will be provided at a later date) Program:This morning event will feature several highlights:A warm welcome for groups to get the day off to a good start.Introductory lecture session: Mini-lectures in plenary sessions will address a variety of compelling topics, setting the stage and sparking curiosity about current mathematical themes.Parallel and successive practical workshops: After a short break, students are invited to participate actively. They rotate between three different workshops, offered in parallel. These sessions encourage experimentation and hands-on learning in small groups on specific topics.Offer your students a free and enriching morning to (re)discover the joy of mathematics!This activity is organized with the support of Wallonia Research.

On the occasion of the International Day of Women and Girls in Science proclaimed on February 11 by the United Nations General Assembly, and as part of the European alliance European Space University for Earth and Humanity (UNIVERSEH) focusing on the theme of space, discover the testimonies of four women scientists from UNamur working on astronomical themes.

In an ever-changing world, where health, environmental and societal crises are intertwined, it is becoming imperative to rethink health in a global and interconnected approach. It was against this backdrop that the Faculty of Medicine at the University of Namur inaugurated its new "One Health" teaching unit (UE) on Thursday February 06, 2025, in the presence of Minister Yves Coppieters. This initiative, offered to all UNamur undergraduates, aims to train tomorrow's healthcare professionals in a systemic vision, where human, animal and environmental health are considered as one and the same reality.

Jury Prof. Benoît MUYLKENS (URVI, Université de Namur), PresidentProf. Carine MICHIELS (URBC, Université de Namur), SecretaryProf. Xavier DE BOLLE (URBC, Université de Namur)Prof. René REZSOHAZY (LIBST, Université catholique de Louvain)Prof. Florian STEINER (Dept. of Molecular and Cellular Biology, Université de Genève)Prof. Germano CECERE (Department of developmental and Stem Cell Biology, Institut Pasteur) Summary In animals, germ cells are often distinguished from somatic lineages at the earliest stages of embryogenesis. In some organisms, germ blastomeres appear to enter a state of transcriptional quiescence. For example, in the worm Caenorhabditis elegans, transcription is activated in somatic blastomeres as early as the 4-cell stage, whereas it is not initiated in germline blastomeres until the 100-cell stage. This transcriptional repression in germ blastomeres has been attributed to the PIE-1 protein, specifically localized in these cells from the first embryonic division. PIE-1 is thought to inhibit the activity of CDK-9, a cyclin-dependent kinase previously considered essential for the phosphorylation of serine 2 (CTD-Ser2) of the C-terminal domain (CTD) of RNA polymerase II and for transcription elongation. However, recent studies, showing that embryogenesis proceeds normally in a mutant strain expressing a CTD in which serines 2 is replaced by an alanine (CTD-S2A) and identifying CDK-12 as the main kinase phosphorylating CTD-Ser2, call this model into question.To study the transcriptome of germline blastomeres in the worm C. elegans, an approach combining cell sorting and RNA sequencing (RNA-seq) was developed. Pilot analyses validated this method on a wild-type strain, enabling its use on a strain in which PIE-1 can be specifically degraded using the Auxin-Inducible Degron (AID) system. This made it possible to examine the effect of PIE-1 depletion on the transcriptome of germline blastomeres revealing that in its absence, germline blastomeres adopt a transcriptional profile close to that of somatic blastomeres, confirming the fundamental role of PIE-1 in preserving germline identity during embryogenesis. In parallel, the fission yeast Schizosaccharomyces pombe was used to analyze the consequences of PIE-1 expression in a heterologous organism. The results showed that PIE-1 by localizing near transcription termination sites induces further transcription by RNA polymerase II beyond the termination site, leading to transcription of intergenic regions. These observations led to the hypothesis that in C. elegans,within germinal blastomeres, PIE-1 might regulate alternative polyadenylation in 3' untranslated regions, producing longer RNA isoforms susceptible to degradation. In the absence of PIE-1, shorter isoforms could be generated, allowing accumulation of somatic transcripts and potentially degradation of maternal mRNAs via somatic protein translation. Although further investigations are required in C. elegans to validate this hypothesis, it provides an innovative conceptual framework for understanding the role of PIE-1, independent of CTD-Ser2 phosphorylation.

Jury Prof. Marielle BOONEN (UNamur), presidentProf. Henri-François RENARD (UNamur), secretaryProf. Claire HIVROZ (PSL University)Prof. Michel GHISLAIN (UCLouvain)Prof. Pierre VAN DER BRUGGEN (UCLouvain)Prof. Ludger JOHANNES (PSL University)Prof. Pierre MORSOMME (UCLouvain) Summary Clathrin-independent endocytosis (CIE) mediates the cellular uptake of endogenous and exogenous cargoes, including bacterial toxins and viruses. Endophilin A3-mediated endocytosis is a specific CIE mechanism that differs from fast endophilin-mediated endocytosis (FEME), with ALCAM and L1CAM being the first confirmed Endophilin A3-specific cargoes. Here, we report ICAM1 as a new Endophilin A3-dependent endocytic cargo. ALCAM and ICAM1 are important components of immune synapses (IS), which are polarized structures formed between immune cells and target cells, such as cancer cells. These molecules transduce essential co-stimulatory signals to T cells to help their effective activation and proliferation. We find that both ALCAM and ICAM1 serve as cargoes for retromer-dependent retrograde transport to the trans-Golgi network (TGN) in cancer cells. Interestingly, disrupting Endophilin A3-mediated endocytosis or retromer-dependent retrograde transport machinery impairs activation of autologous cytotoxic CD8 T cells, possibly by affecting the polarized redistribution of immune synapse components at the plasma membrane. Altogether, our findings demonstrate that CIE and retrograde transport are key pathways in cancer cells that promote the activation of cytotoxic CD8 T cells.