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Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

An international research team led by the Swedish University of Agricultural Sciences has uncovered how pharmaceutical pollution alters the behaviour and migration patterns of Atlantic salmon in nature. Professor Eli Thoré, from the Department of Biology and the ILEE research institute at the University of Namur, contributed to this groundbreaking field study, which has just been published in Science.

The three Belgian scientific experiments selected to be carried out on board the International Space Station (ISS) during astronaut Raphaël Liégeois' mission in 2026 have just been unveiled by the Federal Science Policy Public Service (Belspo). One of them is carried by a team from UNamur for an experiment at the crossroads of biology and physics aimed at analyzing the resistance of the "blob", an atypical unicellular organism.

Brendan Reid has just joined the Environmental and Evolutionary Biology Research Unit (URBE) team in the Department of Biology, Faculty of Science. This unit functions as a collaborative ecosystem, bringing together skills and expertise to advance research on organisms and their dynamic interactions with the environment. Dive into aquatic and semi-aquatic research!

South America is a subcontinent rich in natural and cultural resources. Between biodiversity preservation and development cooperation, UNamur maintains valuable partnerships to address the challenges of biodiversity loss and understand current socio-economic transformations. Immersion in Ecuador and Peru. 

Are we prisoners of our genetic heritage? Can filiation be reduced to genes alone? Can we escape our destiny? Existential questions we all ask ourselves, and to which Gaëlle Pontarotti, lecturer and researcher in the Department of Sciences, Philosophies and Societies at UNamur, sheds new light in her book Par-delà les gènes. Une autre histoire de l'hérédité, published last October by Gallimard.

Today, our planet is undergoing major climatic changes. Particularly in the face of rising temperatures, it is not easy to predict how flora and fauna will react and adapt in disturbed ecosystems. International research, in which Professor Johan Yans' team (Department of Geology and ILEE Institute) is taking part, has found some answers in fossils, which have been the memory of Darwinian evolution for millions of years. Explanations.

The F.R.S.-FNRS has just published the results of its various 2025 calls for proposals. These include the "Credits & Projects" and "WelCHANGE" calls, as well as the "FRIA" (Fund for Research Training in Industry and Agriculture) and "FRESH" (Fund for Research in the Humanities) calls, which aim to support doctoral theses. What are the results for UNamur? Twenty-eight projects have been selected, demonstrating the quality and richness of research at UNamur. 

Well hidden from passersby, caves nevertheless conceal particularly aesthetic secrets. For the past four years, Martin Vlieghe has been pursuing a PhD in geology at UNamur.  He is exploring the origin of the surprisingly varied colours of certain concretions nestled in the heart of Belgian and French caves. Together with Prof. Johan Yans and Gaëtan Rochez, he samples, observes, and analyses these magnificent objects with the aim of uncovering the mysteries they conceal.

In the coming months, the University of Namur will participate in an exceptional space mission aboard the International Space Station (ISS), alongside Belgian astronaut Raphaël Liégeois. The BeBlob project, led by researchers Boris Hespeels (ILEE Institute) and Anne-Catherine Heuskin (NARILIS Institute), aims to study the DNA repair capabilities of a fascinating organism: the blob (Physarum polycephalum).

JuryProf. Nicolas DENDONCKER (UNamur), ChairProf. Sabine HENRY (UNamur), SecretaryProf. Frédéric SILVESTRE (UNamur)Dr. Sébastien DUJARDIN (UNamur)Prof. Kara PELLOWE (Stockholm University)Prof. Romain GLELE KAKAI (University of Abomey Calavi)Prof. Patrick KESTEMONT (UNamur)Prof. Eli THORE (UNamur)AbstractMangroves play an important role in environmental conservation and livelihood provision yet remain one of the most threatened ecosystems on earth. This doctoral study assesses pathways to enhance coastal sustainability in the Anthropocene, by promoting the sustainable use of mangroves and strengthening their social-ecological resilience through an interdisciplinary approach. The thesis is structured into four specific objectives: assessing the role of traditional beliefs and local deities in promoting the sustainable use of mangroves, analyzing the synergies between legal frameworks and traditional beliefs in enhancing the social-ecological resilience of mangroves, developing a novel interdisciplinary framework to evaluate the social-ecological resilience of mangroves, and operationalizing the proposed framework in Benin's mangroves, West Africa.  We collected field data using ethnobiological surveys, drone image analysis and document review, in-depth interviews, focus group discussions, plant and fish inventories across three coastal communities in Benin. The study draws insights from the seven principles of resilience to analyze mangrove sustainability. The interdisciplinary methodology of this study links plant biology, fisheries sciences, and human geography to analyze mangroves as complex social-ecological systems. Findings of the thesis show that traditional beliefs and local deities play a significant role in regulating the use of mangrove resources, while the overlapping of formal and informal institutions offer opportunities to enhance their social-ecological resilience. The novel proposed framework called Mangrove Social Ecological Resilience Appraisal (MaSERA) outlines variables and indicators tailored to mangroves to assess their social-ecological resilience. Its application in Benin highlights its potential in identifying factors that enable or erode mangrove resilience, for informed decision making. The study argues that promoting the sustainable use of mangroves and enhancing their social-ecological resilience represent dual imperatives for achieving coastal sustainability in the Anthropocene. It contributes to the growing body of knowledge on mangrove conservation and provides actionable insights for integrated coastal zone management.