Cell growth, differentiation and death
- UE code MBIMB302
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Schedule
30Quarter 1
- ECTS Credits 3
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Language
French
- Teacher
To understand how an animal (mainly human) eukaryotic cell responds to stimuli from its environment, in terms of proliferation and growth, differentiation and programmed cell death. To understand the intervention of the deregulation of these mechanisms during the development of cancer cells.
To achieve competence in understanding the mechanisms involved in initiating cell growth, differentiation and death; to know the main regulators involved in controlling these phenomena; to understand the regulatory mechanisms and their deregulation in pathological situations, particularly cancer.
Cell growth and differentiation and their normal and pathological control. Signal transduction pathways from stimulus perception (receptor) to regulation of gene expression that are responsible for the adapted cellular response. Apoptosis and autophagy: mechanisms and regulations.
G PROTEIN-COUPLED RECEPTORS
G protein-coupled receptors and regulation of their activity
Adenylyl cyclase and protein kinase A
Phospholipase C and protein kinase C
ACTIVATABLE TRANSCRIPTION FACTORS
Overview of the basal transcription machinery
CREB
GROWTH FACTOR PATHWAY AND THE CELL CYCLE
Growth factors
Receptors with tyrosine kinase activity
Proteins with SH2 domains
Small G proteins like Ras
MAP kinase pathway
Activation of AP-1
CELL CYCLE
Characteristics of the cell cycle
Cell cycle control systems
Regulation of cell division and growth
CELL DIFFERENTIATION
Specialized tissues
Stem cells
Tissue renewal
Regulation of gene expression
CELLULAR TRANSFORMATION
Cancer cell growth and oncogenes
APOPTOSIS
Apoptosis and necrosis
The caspase cascade
The Bcl2 protein family and mitochondrial permeabilization
Death receptors
DNA damage and activation of p53
AUTOPHAGY: mechanisms and regulations.
Ex cathedra course based on power-point presentations available on webcampus and on reference books or articles.
Written Exam.
This exam typically includes open-ended questions and multiple-choice questions (MCQs) related to the sections. There is no negative points for the MCQs. The exam is closed-book.
The matters covered by the exam includes everything that will be covered in the course.
Reference textbooks that can be accessed through the library (BUMP) are:
"Molecular Biology of the Cell" (Alberts et al.)
"The Biology of Cancer" (Weinberg)
"Molecular Cell Biology" (Lodish et al.)
Training | Study programme | Block | Credits | Mandatory |
---|---|---|---|---|
Bachelor in Biomedical Sciences | Standard | 0 | 3 | |
Additional teaching units for the master's degree in biomedical sciences (420P) | Standard | 0 | 3 | |
Additional teaching units for the master's degree in biomedical sciences (420P) | Standard | 1 | 3 | |
Bachelor in Biomedical Sciences | Standard | 3 | 3 |