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The Elongator complex is involved in the addition of 5'-carboxylmethyluridine (cm5U)-derived modifications to transfer RNAs (tRNAs), thereby influencing the translation of certain messenger RNAs (mRNAs) and helping to maintain the integrity of the proteome. This complex is involved in a variety of biological processes, and is of particular importance in oncology. The identification of chemical inhibitors of Elongator is of significant interest in both basic and pharmaceutical research.Through a yeast screen, this work reveals a potential new role for Elongator and identifies a chemical inhibitor of the complex. This compound presents itself as an interesting candidate as a pharmacological inhibitor, opening up new perspectives for the search for anti-cancer therapies.

In 1996, the European Union created the Marie Skłodowska-Curie Actions (MSCA), a set of prestigious and competitive grants designed to fund research. Thanks to her, the PROSTAMET project got underway on January 1, an ambitious program focused on training PhD students and discovering new therapeutic avenues against prostate cancer, in which UNamur is participating.

At UNamur's NARILIS Institute, the 'Stress and AGEing' (SAGE) research group, led by Professor Florence Chainiaux, is seeking to understand the biological processes involved in ageing, focusing on the interconnection between exposure to stress and cellular senescence.

Catherine Michaux, a qualified FNRS researcher, is a partner in the European MSCA-Doctoral Network PROSTAMET project. The special feature of this project is that it funds both research and the training of 9 doctoral students within a network of multidisciplinary experts.

More info coming soon! More info on the NARILIS website

A multidisciplinary research team from the University of Namur (UNamur) and the UCL Namur University Hospital (Godinne campus) has just published a study in the journal Acta Neuropathologica that sheds light on some of the mysteries surrounding the origin of the pain experienced by patients with long COVID. Their findings suggest that these painful symptoms may be mediated by an autoimmune response. In other words: patients produce antibodies that attack their own neurons—those responsible for pain perception and deep body sensation, located along the spine. These highly promising results represent a major scientific breakthrough that opens new avenues for better understanding the disease and, ultimately, developing a treatment targeting the painful symptoms of long COVID.

This June 28, 2024, the first twenty-two students of the Certificat interuniversitaire en Langue des Signes de Belgique Francophone (LSFB) et français, are proclaimed at UNamur. This is the first training course in French-speaking Belgium to be entirely designed in sign language for the deaf. It represents a significant step forward in inclusive education and the linguistic and social inclusion of deaf and hard-of-hearing people. It also highlights the strengths of deaf professionals in these fields.

The TineaDiag project is a research project run by UNamur and ULiège with funding from the SPW Research Win²WAL program. It tackles dermatophytoses, skin infections responsible for ringworm, which can affect both humans and animals. The aim? To identify, in dermatophytes, precise cellular markers in order to detect them with sensitivity and certainty, and thus identify infections caused by antifungal-resistant strains.

The F.R.S.-FNRS has just published the results of its various 2024 calls. Equipment calls, research credits and projects, FRIA doctoral grants and Mandant d'Impulsion Scientifique (MIS), there are many instruments to support fundamental research. Find out more about UNamur's results.

Thematic sessionsThe day will be organized in two thematic sessions:Cancer metabolismNew advances in cancer therapyInvited speakersProf. Rebecca FITZGERALD, Early Cancer Institute, University of Cambridge, UKDr. Sébastien DUTERTRE, IBMM, University of Montpellier, FranceProf. Sarah-Maria FENDT, Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven, BelgiumDr. Arnaud BLOMME, Laboratory of Metabolic Regulation, GIGA Institute, University of Liège, Belgium Call for communicationsYoung researchers are invited to submit abstracts for oral communications and posters. All topics related to the field of cancer research are welcome. The deadline for abstract submission is April 1, 2025. Organizing committeeProf. Jean-Pierre Gillet - UNamur, NARILIS, Laboratory of Molecular Cancer BiologyProf. Marc Hennequart - UNamur, NARILIS, Laboratory of Cancer metabolismProf. Marielle Boonen - UNamur, NARILIS, Laboratory of Intracellular Trafficking BiologyProf. Benjamin Beck - ULB, IRIBHMProf. Lionel D'Hondt - CHU UCL Namur, Department of Oncology More info