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Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

Jelena Luyts has been awarded a prize for her research on climate migration in Senegal.

A bilingual French-sign language dictionary (LSFB), which can be queried in both languages, thanks to cutting-edge technology (facial recognition) and access to a vast database compiling more than 4,500 signs, words and expressions.

At the beginning of each academic year, the Board of Trustees grants Namur Research College (NARC) Fellowship status to researchers who demonstrate a high level of research achievement and who have recently received a prestigious award or funding. A look back at the fellowship of Professor Frederik De Laender.

The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) published a report (August 2022) which lists and assesses the different values we place on nature. This is a huge task carried out over three years by experts from all over the world, including Nicolas Dendoncker, professor at the Department of geography and member of the ILEE Institute at the UNamur.

In a new publication, the European Reference Genome Atlas (ERGA) announces the success of its pilot project. This pioneering initiative has brought together a vast collaborative network of researchers and institutions in 33 countries to produce high-quality reference genomes of 98 European species. This continental effort paves the way for a new, inclusive and equitable model of biodiversity genomics.

How can teleworking and face-to-face work be reconciled? How can these professional practices be framed to reinforce the innovative and sustainable dimensions of hybrid work? These are the questions that Michel Ajzen, a specialist in organizational management, is tackling as part of his teaching assignments in the Department of Management Sciences at UNamur. His research focuses on hybrid work and organizational innovation, with a transdisciplinary approach aimed at reinventing managerial practices to meet contemporary challenges.

Floriane Goosse, a PhD student at the University of Namur, within the NaDI-CeRCLe research center, has received the prestigious "Best Research Paper Award" for her thesis paper conducted in collaboration with Wafa Hammedi, professor in the Department of Management at UNamur, and Dominik Mahr, from Maastricht University.

Contact Co-President Bruno Dumas bruno.dumas@unamur.be Co-President Alexandre de Streel alexandre.destreel@unamur.be Organization Discover the members

NADI offers extensive expertise in artificial intelligence: bio-inspired robotics, robust, interactive, interpretable and safe machine learning, automatic program verification, declarative programming, business intelligence, knowledge representation and automatic software testing. This has already led to numerous collaborations with medical experts, industry and civil society. Along with other areas of expertise at NADI, AI experts are also exploring the educational, ethical, societal and legal implications of AI.

The collaborative economy refers to marketplaces that provide access to goods, services or skills through peer-to-peer exchanges. NADI explores the economic, technological and societal/environmental impacts of these exchanges.

Innovation has become increasingly complex. Developing appropriate solutions to our society's growing challenges requires exploring uncommon sources of solutions and combining the efforts of different stakeholders, including citizens or consumers. Co-innovation and co-creation analyze the methods, tools and governance that foster these participatory and collaborative approaches.