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Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

Initiated in 1969 by Pullmann and Del Re, the congress is an annual meeting to promote collaboration and friendship between Latin-speaking theoretical chemists. In its early years, European researchers were the main contributors. Subsequently, the Latin American community has made a major contribution, with the emergence of teams whose international reputation now extends far beyond our own community.We are delighted to be holding this meeting at the University of Namur, 55 years after the first CHITEL was organised in Paris, France. We are sure that this 2024 edition will once again be an opportunity to take advantage of the good humour and dynamism of Latin to encourage, develop and strengthen scientific exchanges.We look forward to welcoming you at the University of Namur,The CHITEL 2024 Local Organising Committee. Website

Success for the interfaith and interdisciplinary colloquium organised by the University Chair Our Lady of Peace and the eponymous research centre, in collaboration with the Abbey of Maredsous.

Let's go and discover the qualified researchers of UNamur, winners of the funding granted by the FNRS in 2022. Today, we meet Michaël Lobet, currently a lecturer at UNamur, who will begin his new mandate as a qualified FNRS researcher at the NISM Institute next fall. The subject of his research: twisted optics for the manipulation of slow photons or how to create light traps. Explanations.

Colloques 14/11/2024 | The Emergence of ConsciousnessInterdisciplinary colloquium organized by ESPHIN (UNamur's Espace Philosophique), with the collaboration of the Centre Universitaire Notre-Dame de la Paix (cUNDP), the Louvain Institute of Biomolecular Science and Technology,and Louvai4evolution (UCLouvain).This free colloquium is aimed at:Specialists, students or PhD students from various disciplines: neuroscience, biology, anthropology, medicine, psychology, philosophy, ethics, computer science, robotics, mathematics, ...People with a passion for interdisciplinarity;Humanists and the curious.Location : Faculty of Philosophy and Letters, rue Grafé 1, Local L22Learn more Ecology of life" seminars It's obvious to anyone paying attention to the paths taken by a growing number of 21st century thinkers: these paths lead to the living! Whether it's called "ecophilosophy", "ecoanthropology", "ecosophy" or "ecopolitics", this way of thinking about the living is occupying a growing place not only in the media and publications of all kinds, but also in concrete actions in a variety of fields.Fashion? Ephemeral trend? Collateral effect of "transitionism" tinged with ambient catastrophism? A new attempt at ecological rebellion? The seminars to which we invite you are intended to be a meeting place - an ecosystem - at the heart of which we will resonate with founding texts of this current that integrates nature, environment, milieu, human and non-human, and straddles the worn-out dualisms of our modern tradition. In other words, we propose to read together some key texts by authors who have attempted to draw lessons from their authentic encounters with other living beings.Program 2024-2025 | At the Roots of the HumanOn December 13 2024 from 2:00 pm to 4:00 pm (intervention, discussions and convivial moment). Quentin HIERNAUX will introduce plant philosophy and tell us about Humboldt's "Tableau physique des Andes" and his equinoctial geography of plants.On February 28, 2025 from 2:00 to 4:00 pm (intervention, discussions and convivial moment), Jean-Baptiste VUILLEROD will address the following theme: Naturphilosophie du végétal : Goethe, Schelling, Humboldt.OnApril 11, 2025from 2:00 to 4:00 pm (intervention, discussions and convivial moment), Roland CAZALIS will share his biologist's point of view on the plant world.Introducing the subjectIf we were to take stock of the history of mankind, one trend would certainly stand out: that of a utilitarian relationship with the non-human that continues to grow, and consequently that of a widening gap between the human and the rest.Humanity, however, has its roots in a living environment that cultivates many other relationships than those we currently privilege, which are dominated by instrumental rationality. Sounding out these forgotten relational universes, without which it is increasingly difficult to think about the human, is one aim of this seminar, which this year will invite you to encounter the plant.Last year we turned our attention to the communal dimension of living things, starting with the work of Aldo Leopold. In particular, the American forester challenged us with a question from which we should never stray: "just what and whom do we love?". His answer, in the middle of the last century, already confirmed the trend evoked above: "Certainly not the soils, which we allow to be scavenged towards the estuaries. Certainly not the waters, which we assume have no other function than to power turbines, carry barges and carry away garbage. Certainly not plants, whose entire communities we exterminate without batting an eyelid. Certainly not the animals, from which we have already extirpated many of the largest and most magnificent species.". In the face of this lack of consideration for what is not us, the earth ethic proposed by Leopold "modifies the role of homo sapiens, who, from conqueror of the earth-community, becomes a full member and citizen of it". It is thus an ethic that "implies respect for other members as well as for the community as such", and "man is ultimately only a member of a biotic team" ("The Ethics of the Earth", in Almanac of a Sand County).To help us rediscover this vital sense of community, this year we'll turn to plant lifestyles: those living things that maintain intimate relationships with light, air, water and everything we call "soil". How can we let ourselves be instructed by the plants without which we could not exist? "By making possible the world of which they are part and content, plants destroy the topological hierarchy that seems to reign in the cosmos. They demonstrate that life is a breaking of the asymmetry between container and content. When there is life, philosopher Emanuele Coccia continues, the container lies within the content (and is therefore contained by it) and vice versa. The paradigm of this reciprocal imbrication is what the ancients already called breath (pneuma). To blow, to breathe, means in effect to have this experience: that which contains us, the air, becomes contained within us and, conversely, that which was contained within us becomes that which contains us." (The Life of Plants).The Tableau Physique (1807) by Alexander von Humboldt:

Board members President: Nicolas Monseu-Van CleemputVice-president: Marie d'Udekem-GeversPhilosophy department representative: Laura RizzerioScience-Philosophies-Society Department representative: Geoffroy de BrabanterAssociate member representative: Bertrand HespelSecretariat: Vénonique OroseWebsite manager: Nathanaël Laurent See all members

While still only a dream, the quantum computer is the subject of intense research. The Artemis project, funded by the European Union (EU) and involving UNamur, aims to develop new sources of single photons, and thus lay the technological foundations. A member of the project, physicist Yves Caudano hopes, at the same time, to further explore the foundations of quantum physics.

ECOBAT is an EOS project (FNRS/FWO) that brings together four universities: UCLouvain, KULeuven, the University of Bonn (Germany), and the University of Namur. This consortium currently mobilizes some twenty researchers at all levels (Masters, PhD students, post-docs, promoters), including Dr. Pierre Beaujean, under the supervision of Professor Benoît Champagne..

HPC-MM representatives Permanent members Prof. Yoann OLIVIER +32 (0) 81 72 45 34 yoann.olivier@unamur.be NOP representatives Permanent members Prof. Olivier DEPARIS +32 (0)81 72 52 35 olivier.deparis@unamur.be Non-permanent members Dr. Sébastien MOUCHET adrien.debacq@unamur.be SICN representatives Permanent members Julien COLAUX +32 (0)81 72 54 70 julien.colaux@unamur.be Non-permanent members Emile HAYE lucas.schoenauen@unamur.be FSM representatives Permanent members Nikolay TUMANOV nikolay.tumanov@unamur.be Non-permanent members Tarek BARAKAT anthony.morena@unamur.be

At the 12th International Congress on Mesostructured Materials (IMMA), held from July 8 to 12 in Montpellier, Prof. Bao-Lian Su was re-elected President of the International Mesostructured Materials Association (IMMA).

Program 8:50 | Welcome, registration, and poster setup9:20 | Welcome speechFirst morning session 9:30 | Vladimir N. Uversky - University of South Florida, USA - "Dancing protein clouds: strange biology and chaotic physics of intrinsically disordered proteins" 10:15 | Marie Skepö - Lunds Universitet, Sweden - "Structural and conformation properties of IDPs: computer simulations in combination with experiments" 11:00 | Coffee breakSecond morning session11:30 | Peter Tompa - Vrije Universiteit Brussel, Belgium - "Fuzzy interactions of IDPs driving biomolecular condensation"12:15 | Sonia Longhi - Aix-Marseille Université, France - "Intrinsic disorder, phase transitions, and fibril formation by the Henipavirus V and W proteins"13:00 | Lunch and poster sessionAfternoon session14:30 | Sigrid Milles - Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Germany - "Intrinsically disordered proteins in endocytosis: an NMR and single molecule fluorescence perspective"15:15 | Jean-François Collet - Université Catholique de Louvain, Belgium - "How disorder controls the transport of lipoproteins in the cell envelope of Gram-negative bacteria" 16:00 | Closing speech16:10 | Networking Beer Time at "Le Chapitre"VenueUniversity of Namur, auditorium Pedro Arrupe (PA02), rue de Bruxelles, 65-67 - 5000 Namur (#21 on the campus map) Download the programme (PDF) Download the campus map Registration guidelines Registration feeStudents (PhD students included): 25 €Seniors: 40 €Payment - Bank transferPayable before 6 December on the account:Name: Université de Namur - ASBLIBAN: BE10 2500 0740 2704BIC: GEBABEBBPlease mention your name/CPO4136330 /e-mail in the payment communication. Abstract guidelines Send us your abstract before 6 December by email: pdid.meeting@unamur.beFormat: Word document, maximum 1 page A4, Times New Roman  Registration All deadlines (registration, payment, abstracts) : 6 December 2024

will take place from September 2 to 6, 2024 at the Gîte du domaine d'Haugimont (owned by the University of Namur) and will deal with medieval manuscripts in their material and historical aspects (parchment and ink manufacture). The event is aimed at historians, archaeologists and researchers in the physical and chemical sciences. Participation is free for doctoral students attached to FNRS doctoral schools in the disciplines concerned. At the crossroads of archaeology, history and the exact sciences, this colloquium-workshop will give the floor to three speakers (a physicist, a chemist and a historian) who will present the interdisciplinary research they are conducting together in this field. Workshops on parchment reproduction, inks and writing materials will be held each day.More information on the event .