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Beautiful victory for Margaux Mignolet, a researcher at the Faculty of Medicine's Unité de Recherche en Physiologie Moléculaire (URPhyM), who wins 1st prize in the Belgian inter-university final of the Ma thèse en 180 secondes (MT180) competition. Her research? To better understand the mechanisms of antibodies active in cases of long COVID. The second prize in this national competition was also won by a candidate from Namur. It was Petra Manja, from the Unité de Recherche en biologie des micro-organismes (URBM), Department of Biology, Faculty of Science, and is pursuing a thesis aimed at understanding resistance mechanisms in the bacterium E. coli. Both are also researchers at the NARILIS Institute.

A major breakthrough for the health of women on oral contraceptives has been achieved by researchers in Namur. Every year in Europe, more than 22,000 cases of venous thrombosis or embolism occur among contraceptive pill users. A team of researchers from the University of Namur, in collaboration with QUALIblood (spin-off), has conducted an important study, the results of which could transform prescribing recommendations..

Bringing a new drug to market, particularly when it is intended to treat a pediatric or orphan disease, is a journey fraught with pitfalls. The ERAMET project, coordinated by Professor Flora Musuamba Tshinanu, aims to overhaul the assessment procedures, so that regulatory agencies can take innovative technologies into account and thus make more informed choices.

Can a computer learn a language like a child? A recent study published in the leading journal Computational Linguistics by Professors Katrien Beuls (Université de Namur) and Paul Van Eecke (AI-lab, Vrije Universiteit Brussel) sheds new light on this question. The researchers argue for a fundamental revision of the way artificial intelligence acquires and processes language.

Founded some 50 years ago, the Laboratoire d'Analyse par Réactions Nucléaires (LARN) in the Department of Physics at the University of Namur is home to a 2MV tandem particle gas pedal named ALTAÏS (Accélérateur Linéaire Tandetron pour l'Analyse et l'Implantation des Solides), in operation since 1999.

The three Belgian scientific experiments selected to be carried out on board the International Space Station (ISS) during astronaut Raphaël Liégeois' mission in 2026 have just been unveiled by the Federal Science Policy Public Service (Belspo). One of them is carried by a team from UNamur for an experiment at the crossroads of biology and physics aimed at analyzing the resistance of the "blob", an atypical unicellular organism.

On May 10, 2025, Vice-Rector Carine Michiels and Professor Anne-Catherine Heuskin handed over UNamur's cheque at the grand closing evening of Operation Télévie, which this year raised a record €13,351,977 for the Fonds National de la Recherche Scientifique. Télévie funds are used entirely to finance cancer research projects at universities in the Wallonia-Brussels Federation and the Grand Duchy of Luxembourg.

This summer's third and final focus on the NaDI-CeRCLe research center, which has gained international recognition in recent weeks thanks to awards won by three young researchers in service management. Following on from Floriane Goosse and Victor Sluÿters, we invite you to discover the work of Florence Nizette, a young researcher working on Artificial Intelligence technologies.

Researchers at the Universities of Namur (UNamur), Brussels (ULB) and Liège (ULiège) have just taken a key step towards understanding viral mechanisms. Their study, published in the international scientific journal PLOS Pathogens, focuses on a particular type of molecule produced by viruses, circular RNAs, and presents an innovative bioinformatics tool capable of better identifying them.

Abstract Primarily described as an alarmone, secondary messenger (p)ppGpp, when accumulated, binds to many targets involved in DNA replication, translation, and transcription. In the asymmetrically-dividing a-proteobacterium Caulobacter crescentus, (p)ppGpp has been shown to strongly impact cell cycle progression and differentiation, promoting the non-replicating G1/swarmer phase. Mutations in the major subunits of transcriptional complex, b or b' subunits, were able to display the (p)ppGpp-related phenotypes even in the absence of the alarmone. We identified that the transcriptional holo-enzyme, RNA polymerase (RNAP) is a primary target of (p)ppGpp in C. crescentus. Furthermore, mutations that inactivate (p)ppGpp binding to RNAP annihilated the (p)ppGpp-related phenotypes and phenocopied a (p)ppGpp0 strain. Our RNAseq analysis further elucidated the changes in the transcriptional landscape of C. crescentus cells displaying different (p)ppGpp levels and expressing RNAP mutants. Since the DNA replication initiation protein DnaA is required to exit the G1 phase, we observed that it was significantly less abundant in cells accumulating (p)ppGpp. We further explored its proteolysis under the influence of (p)ppGpp. Our work suggests that (p)ppGpp regulates cell cycle and differentiation in C. crescentus by reprogramming transcription and triggering proteolytic degradation of key cell cycle regulators by yet unknown mechanisms. In Part II, we identified two σ factors belonging to the ECF family that might be involved in this (p)ppGpp-accompanied phenotypes. In Part III, we propose an overlapping role of the ω subunit, RpoZ, and the heat shock subunit, RpoH, in carbon metabolism.JuryProf. Gipsi LIMA MENDEZ (UNamur), PresidentProf Régis HALLEZ (UNamur), SecretaryDr Emanuele BIONDI (CNRS-Université Paris-Saclay)Prof. Justine COLLIER (University of Lausanne)Dr Marie DELABY (Université de Montréal)

Abstract Estrogens originating from human and animal excretion, as well as from anthropogenic sources such as cosmetics, plastics, pesticides, detergents, and pharmaceuticals, are among the most concerning endocrine-disrupting compounds in aquatic environments due to their potent estrogenic activity. While their effects on fish reproduction are well documented, their impact on development, particularly metamorphosis, remains poorly studied. This hormonal transition, mainly controlled by the thyroid axis, is essential for the shift from the larval to the juvenile stage in teleosts.The effects of two contraceptive estrogens on zebrafish (Danio rerio) metamorphosis were evaluated: 17α-ethinylestradiol (EE2), a synthetic reference estrogen, and estetrol (E4), a natural estrogen recently introduced in a new combined oral contraceptive formulation. Continuous exposure from fertilization to the end of metamorphosis allowed the assessment of morphological changes, disruptions of the thyroid axis, and modifications of additional molecular pathways potentially involved in metamorphic regulation.EE2 induced significant delays and disturbances in metamorphosis, affecting both internal and external morphological traits, confirming its role as an endocrine disruptor of concern. In contrast, E4 did not cause any detectable morphological alterations even at concentrations far exceeding those expected in the environment, indicating a limited ecotoxicological risk. Molecular analyses showed that EE2 strongly affected thyroid signaling and energy metabolism during metamorphosis, whereas E4 induced only minor transcriptional and proteomic changes.This study provides the first evidence that EE2 can disrupt zebrafish metamorphosis and highlights the importance of including this developmental stage in ecotoxicological assessments. The results also suggest a larger environmental safety margin for E4, although further research is needed to clarify the mechanisms linking estrogen exposure to metamorphic regulation.JuryProf. Frederik DE LAENDER (UNamur), PresidentProf. Patrick KESTEMONT (UNamur), SecretaryDr. Sébastien BAEKELANDT (UNamur)Dr. Valérie CORNET (UNamur)Prof. Jean-Baptiste FINI (Muséum National d'Histoire Naturelle, Paris)Dr. Marc MULLER (ULiège)Prof. Veerle DARRAS (KULeuven)

A flurry of awards for the NaDI-CeRCLe research center in recent weeks. The service management research of three young doctoral students from the EMCP Faculty has been recognized by their peers at leading international scientific events: Floriane Goosse, Victor Sluÿters and Florence Nizette. This summer, we invite you to discover their careers and their work.