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Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

What exactly did the ancient Egyptians eat? How did they prepare and preserve their food? What was their nutritional value? René Preys, an Egyptologist at UNamur, is currently involved in this astonishing research. This expert is a major figure in Belgian Egyptology. Interview.

In 2021, the European Union has embarked on a titanic project to safeguard the genomes of all eukaryotic species in Europe. In other words, all living organisms, with the exception of bacteria and archaea (micro-organisms). Called ERGA, for European Reference Genome Atlas, and in which UNamur is participating thanks to Professor Alice Dennis, this project hopes to help safeguard biodiversity, at a time when a fifth of European species are in danger of extinction..

will take place from September 2 to 6, 2024 at the Gîte du domaine d'Haugimont (owned by the University of Namur) and will deal with medieval manuscripts in their material and historical aspects (parchment and ink manufacture). The event is aimed at historians, archaeologists and researchers in the physical and chemical sciences. Participation is free for doctoral students attached to FNRS doctoral schools in the disciplines concerned. At the crossroads of archaeology, history and the exact sciences, this colloquium-workshop will give the floor to three speakers (a physicist, a chemist and a historian) who will present the interdisciplinary research they are conducting together in this field. Workshops on parchment reproduction, inks and writing materials will be held each day.More information on the event .

The wolf, long banished from our lands, has made a remarkable comeback in Wallonia since 2016. This mysterious being, now protected, arouses as much fascination as fear. Through an exhibition, held as part of the Cultural Project course, third-year history bachelor students have traced the history of the wolf. From April 11 to 27, 2024, the exhibition entitled "Même pas peur! Une évolution de l'image du loup à travers les siècles" invited audiences to plunge into the heart of a historical exploration.

Stanford University has published a prestigious ranking that highlights the most influential researchers in a wide range of scientific fields. The list, based on bibliographic criteria, aims to provide a standardized means of identifying the world's scientific leaders. It is one criterion among others for assessing the quality of scientific research. Twelve researchers from the University of Namur are among them!

Researchers from UNamur's Departments of Biology and Physics have conducted a scientific experiment to assess the radioresistance of the common black ant Lasius niger. The results of their work have just been published in the Belgian scientific journal Belgian Journal of Zoology. The Namur-based scientists demonstrate a level of resistance far superior to that of humans. Their spontaneous approach also demonstrates a lesser-known approach to scientific research.

With oral and poster presentations by ILEE affiliates. Students and young researchers are particularly invited to present their research and practice their presentation skills in English. The day is also important for ILEE members as it enables them to keep abreast of ongoing projects in different disciplines and to foster collaboration.At the end of the day, the annual general meeting of all members will take place with a summary of the past year's activities and achievements.We are honored to announce that Arnaud Péters, PhD in history and founder of sites_H, will be the keynote speaker!

Research centers AcanthuM (Monumental, archaeological and artistic heritage) See content ARaiRe (Recherches namuroises en histoire Rurale, 1500-1850) See content Fontes Antiquitatis center See content HiSI research center (History, sounds and images) See content Pratiques médiévales de l'écrit (PraME) research center See content

Contacts Fulgence DELLEAUX +32 (0)81 72 41 93 fulgence.delleaux@unamur.be Jean-François NIEUS +32 (0)81 72 41 94 jean-francois.nieus@unamur.be

David Bardey (PraME)Disappearance of jewels and letters at the abbey. Enquête sur les héritages de Guillaume de Vienne, seigneur de Saint-Georges (Cîteaux, 1344)Alexis Fontbonne (PraME)La notion de champ ecclésial