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Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

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Jelena Luyts has been awarded a prize for her research on climate migration in Senegal.

At the beginning of each academic year, the Board of Trustees grants Namur Research College (NARC) Fellowship status to researchers who demonstrate a high level of research achievement and who have recently received a prestigious award or funding. A look back at the fellowship of Professor Frederik De Laender.

Since 1996, the European Radiation Research Society (ERRS) has awarded the Bacq and Alexander Prize each year to an outstanding European researcher in recognition of the recipient's achievements in the field of radiation research. This year, the award was presented to Professor Carine Michiels, from the University of Namur.

The lysosome, a small intracellular organelle, is often represented as the stomach of the cell due to its acidity and the presence of numerous digestive enzymes within it. Its role? The degradation of numerous molecules and their recycling to build new molecules and fuel energy production in the cells. Since 2003, Marielle Boonen has been particularly interested in the lysosome. Together with researchers from UNamur, she has highlighted the role of a lysosomal enzyme called HYAL1 in the bone remodelling process.

The Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) published a report (August 2022) which lists and assesses the different values we place on nature. This is a huge task carried out over three years by experts from all over the world, including Nicolas Dendoncker, professor at the Department of geography and member of the ILEE Institute at the UNamur.

When a tumour develops in an organism, it is very common for the cancer cells to leave the tumour and move to another organ where they proliferate, creating what are known as metastases. This process is an important factor in mortality, as it means that the disease worsens. Hence the interest in better understanding what happens during this phenomenon. This is what the multidisciplinary team of Carine Michiels, researcher at the NARILIS Institute of UNamur, and Davide Bonifazi, researcher at the University of Vienna, did in the framework of the PACMAN research project financed by the FNRS. The results of this study are published in the journal Neoplasia.

In a new publication, the European Reference Genome Atlas (ERGA) announces the success of its pilot project. This pioneering initiative has brought together a vast collaborative network of researchers and institutions in 33 countries to produce high-quality reference genomes of 98 European species. This continental effort paves the way for a new, inclusive and equitable model of biodiversity genomics.

ILEE combines a broad range of basic, applied and social science skills that focus on three key areas of study, including historical perspectives and extensive partnerships with the global South.

The availability of natural resources for future generations can only be ensured through prudent use.

Through a variety of chemical, biological and physical factors, humans are modifying ecosystems, often with negative results. Environmental changes, in turn, affect the dynamics of human populations.