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Beautiful victory for Margaux Mignolet, a researcher at the Faculty of Medicine's Unité de Recherche en Physiologie Moléculaire (URPhyM), who wins 1st prize in the Belgian inter-university final of the Ma thèse en 180 secondes (MT180) competition. Her research? To better understand the mechanisms of antibodies active in cases of long COVID. The second prize in this national competition was also won by a candidate from Namur. It was Petra Manja, from the Unité de Recherche en biologie des micro-organismes (URBM), Department of Biology, Faculty of Science, and is pursuing a thesis aimed at understanding resistance mechanisms in the bacterium E. coli. Both are also researchers at the NARILIS Institute.

A major breakthrough for the health of women on oral contraceptives has been achieved by researchers in Namur. Every year in Europe, more than 22,000 cases of venous thrombosis or embolism occur among contraceptive pill users. A team of researchers from the University of Namur, in collaboration with QUALIblood (spin-off), has conducted an important study, the results of which could transform prescribing recommendations..

Bringing a new drug to market, particularly when it is intended to treat a pediatric or orphan disease, is a journey fraught with pitfalls. The ERAMET project, coordinated by Professor Flora Musuamba Tshinanu, aims to overhaul the assessment procedures, so that regulatory agencies can take innovative technologies into account and thus make more informed choices.

Founded some 50 years ago, the Laboratoire d'Analyse par Réactions Nucléaires (LARN) in the Department of Physics at the University of Namur is home to a 2MV tandem particle gas pedal named ALTAÏS (Accélérateur Linéaire Tandetron pour l'Analyse et l'Implantation des Solides), in operation since 1999.

The IPCC warns of the growing impact of global warming on water, with more frequent droughts and floods threatening global supplies. By 2050, 42% of river basins will be severely affected, and flood damage could quadruple in the event of 4°C warming. Although they bear little responsibility, the most vulnerable populations suffer the worst consequences. In Wallonia, recent climatic disasters and water pollution illustrate the stakes. To raise public awareness, an event is being organized in Charleroi with debates and screenings.Program17:00 | Introductory session Head of UNESCO Belgium Mr Aurélien Dumont, Secretariat of UNESCO's Intergovernmental Hydrological Programme, World Water Situation17:40 | Screening of the film "H2O, water, life and us: the Emergency"18:30 | Break18:45 | Lectures and debate Prof. Dr. Marnik Vanclooster (U.K.). Marnik Vanclooster (UCLouvain), "Situation en Wallonnie" Prof. Alfred Bernard (UCLouvain), "Normes et toxicologie" Debate Moderated by Prof. Karim ZouaouiBouin (UCLouvain). Karim ZouaouiBoudjeltia (ULB), with the participation of Aurélien Dumont, Marnik Vanclooster, Alfred Bernard.20:30 | Cocktail dinnerGRATULAR : Registration required: f.amer@wbi.beThe members of the "exact and natural sciences" Sub-CommissionBernard Feltz (UCLouvain, Chairman), Bertrand Hespel (UNamur), Marie-Geneviève Pinsart (ULB, CIGB), René Rezsohazy (UCLouvain), Frédéric Rychter (Secrétaire général), Olivier Sartenaer (UNamur), Didier Serteyn (ULiège), Anne Staquet (UMons), Marnik Vanclooster (UCLouvain), Karim Zouaoui Boudjeltia (ULB)

The three Belgian scientific experiments selected to be carried out on board the International Space Station (ISS) during astronaut Raphaël Liégeois' mission in 2026 have just been unveiled by the Federal Science Policy Public Service (Belspo). One of them is carried by a team from UNamur for an experiment at the crossroads of biology and physics aimed at analyzing the resistance of the "blob", an atypical unicellular organism.

On May 10, 2025, Vice-Rector Carine Michiels and Professor Anne-Catherine Heuskin handed over UNamur's cheque at the grand closing evening of Operation Télévie, which this year raised a record €13,351,977 for the Fonds National de la Recherche Scientifique. Télévie funds are used entirely to finance cancer research projects at universities in the Wallonia-Brussels Federation and the Grand Duchy of Luxembourg.

Researchers at the Universities of Namur (UNamur), Brussels (ULB) and Liège (ULiège) have just taken a key step towards understanding viral mechanisms. Their study, published in the international scientific journal PLOS Pathogens, focuses on a particular type of molecule produced by viruses, circular RNAs, and presents an innovative bioinformatics tool capable of better identifying them.

The notion of "academic freedom" is often evoked in public debates, but is it really known in its singularity? Where does it come from? What is its history? What decisive role does it play in our democracies and the defense of the university's role as a counter-power? To what extent is it threatened today, particularly by the reforms announced?This morning of reflection, open to all, will explore these questions from a variety of perspectives. Historians, philosophers and jurists will shed light on the subject. Institutional leaders will share their concrete experience and their analysis of the threats that reforms could pose to this essential principle.An organization of the Philosophy Department, the History Department, the ESPHIN Institute in collaboration with the Centre d'Action Laïque Namur.The speakers- Anne-Emmanuelle Bourgaux, Professor of Constitutional Law at the University of Mons- Nicolas Offenstadt, Professor of History at the University of Paris 1 Panthéon-Sorbonne- Quentin Landenne, Qualified Researcher at the FRS-FNRS at the UCLouvain Saint-Louis Brussels, scientific leader of the ERC BildungLearning project- Susanna Zellini, Research Fellow at the FRS-FNRS at UCLouvain Saint-Louis Brussels- Annick Castiaux, Rector of UNamur- Edouard Delruelle, Professor of political philosophy at ULiège; Chargé de mission by the Rectrice of ULiège on "ULiège facing global conflicts".PracticalitiesThéâtre Jardin Passion 39, rue Marie Henriette - 5000 Namur.Free admission - Welcome from 9amAn organization of the Departments of Philosophy and History of the University of Namur and the ESPHIN Institute in collaboration with the Centre d'Action Laïque Namur with the support of the ERC BildungLearning project. I want to register The ERC BildungLearning project is funded by the European Union (n° 101043433). The views and opinions expressed, however, are those of the authors alone and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.

Abstract Primarily described as an alarmone, secondary messenger (p)ppGpp, when accumulated, binds to many targets involved in DNA replication, translation, and transcription. In the asymmetrically-dividing a-proteobacterium Caulobacter crescentus, (p)ppGpp has been shown to strongly impact cell cycle progression and differentiation, promoting the non-replicating G1/swarmer phase. Mutations in the major subunits of transcriptional complex, b or b' subunits, were able to display the (p)ppGpp-related phenotypes even in the absence of the alarmone. We identified that the transcriptional holo-enzyme, RNA polymerase (RNAP) is a primary target of (p)ppGpp in C. crescentus. Furthermore, mutations that inactivate (p)ppGpp binding to RNAP annihilated the (p)ppGpp-related phenotypes and phenocopied a (p)ppGpp0 strain. Our RNAseq analysis further elucidated the changes in the transcriptional landscape of C. crescentus cells displaying different (p)ppGpp levels and expressing RNAP mutants. Since the DNA replication initiation protein DnaA is required to exit the G1 phase, we observed that it was significantly less abundant in cells accumulating (p)ppGpp. We further explored its proteolysis under the influence of (p)ppGpp. Our work suggests that (p)ppGpp regulates cell cycle and differentiation in C. crescentus by reprogramming transcription and triggering proteolytic degradation of key cell cycle regulators by yet unknown mechanisms. In Part II, we identified two σ factors belonging to the ECF family that might be involved in this (p)ppGpp-accompanied phenotypes. In Part III, we propose an overlapping role of the ω subunit, RpoZ, and the heat shock subunit, RpoH, in carbon metabolism.JuryProf. Gipsi LIMA MENDEZ (UNamur), PresidentProf Régis HALLEZ (UNamur), SecretaryDr Emanuele BIONDI (CNRS-Université Paris-Saclay)Prof. Justine COLLIER (University of Lausanne)Dr Marie DELABY (Université de Montréal)

Abstract Estrogens originating from human and animal excretion, as well as from anthropogenic sources such as cosmetics, plastics, pesticides, detergents, and pharmaceuticals, are among the most concerning endocrine-disrupting compounds in aquatic environments due to their potent estrogenic activity. While their effects on fish reproduction are well documented, their impact on development, particularly metamorphosis, remains poorly studied. This hormonal transition, mainly controlled by the thyroid axis, is essential for the shift from the larval to the juvenile stage in teleosts.The effects of two contraceptive estrogens on zebrafish (Danio rerio) metamorphosis were evaluated: 17α-ethinylestradiol (EE2), a synthetic reference estrogen, and estetrol (E4), a natural estrogen recently introduced in a new combined oral contraceptive formulation. Continuous exposure from fertilization to the end of metamorphosis allowed the assessment of morphological changes, disruptions of the thyroid axis, and modifications of additional molecular pathways potentially involved in metamorphic regulation.EE2 induced significant delays and disturbances in metamorphosis, affecting both internal and external morphological traits, confirming its role as an endocrine disruptor of concern. In contrast, E4 did not cause any detectable morphological alterations even at concentrations far exceeding those expected in the environment, indicating a limited ecotoxicological risk. Molecular analyses showed that EE2 strongly affected thyroid signaling and energy metabolism during metamorphosis, whereas E4 induced only minor transcriptional and proteomic changes.This study provides the first evidence that EE2 can disrupt zebrafish metamorphosis and highlights the importance of including this developmental stage in ecotoxicological assessments. The results also suggest a larger environmental safety margin for E4, although further research is needed to clarify the mechanisms linking estrogen exposure to metamorphic regulation.JuryProf. Frederik DE LAENDER (UNamur), PresidentProf. Patrick KESTEMONT (UNamur), SecretaryDr. Sébastien BAEKELANDT (UNamur)Dr. Valérie CORNET (UNamur)Prof. Jean-Baptiste FINI (Muséum National d'Histoire Naturelle, Paris)Dr. Marc MULLER (ULiège)Prof. Veerle DARRAS (KULeuven)

Hepatocellular carcinoma is the most common primary liver cancer. Unfortunately, this tumor still has a high mortality rate due to the lack of effective treatments for its most advanced or poorly localized forms. As part of a partnership with the CHU UCL Namur - site de Godinne and with the support of Roche Belgium, researchers in the Department of Biomedical Sciences are trying to understand why liver tumor cells are so resistant to treatment, and to identify therapeutic alternatives to better target them.