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As part of the English course of the Bachelor in Science and Medicine, students are introduced to the oral popularisation of scientific concepts. This year, these future biologists, chemists, geologists/geographers or pharmacists expressed themselves in the form of videos inspired by the famous French science popularisation programme, "C'est pas sorcier". A competition to choose the best video has been launched as part of the Printemps des sciences.

A frightening figure in traditional tales, the wolf is the object of a myth carried by the popular memory of our elders. Long gone from our landscapes, this large predator is making a comeback in Wallonia and is posing us with major challenges. Does it still have a place? A historian and a veterinarian talk about this fascinating natural phenomenon.

The wolf, a majestic animal that has had many tumultuous adventures with man. Respected in ancient Rome, then demonised from the Middle Ages onwards, the wolf is now gaining ground in Belgium after having disappeared from our lands since the end of the 19th century. This subject was at the heart of the conference "Return of the wolf in the Walloon Region", organised by UNamur on 9 March 2023. This was an opportunity to decipher the past and present presence of the wolf in our countryside and forests, with Julie Duchêne, FRESH-FNRS doctoral student in History, and Benoit Muylkens, Head of the Department of veterinary medicine.

(Update 04/04: This article is "an April Fool") A remarkable event took place during Printemps des sciences, which ran from March 18 to 24, 2024. While a visit to the UNamur Astronomical Observatory was offered to the general public on the evening of March 23, a unique phenomenon occurred.

Lately, and thanks to LUMI, one of Europe's largest supercomputers, the limits of our knowledge of cell lipid membranes have been pushed back. A team of Namur researchers, including Professor Benoît Champagne and Drs. Pierre Beaujean and Charlotte Bouquiaux, has just published in the Journal of Chemical Information and Modeling. The results of this study pave the way for new approaches in the field of membrane lipid therapy.

One year after receiving funding from the European Research Council (ERC) for his B-Yond project, Prof Guillaume Berionni has just been named a Fellow of the prestigious European chemistry society Chemistry Europe. This distinction makes him the new representative for Belgium for a period of 2 years.

How does chemistry play a part in developing innovative, sustainable solutions for society's current and future challenges? What unique teaching methods does UNamur use to train enlightened leaders in the field of chemistry? On the occasion of its 50th anniversary, the Department of Chemistry lifts the veil on some of its major research projects and innovative teaching practices.

EMBO Courses and Workshops are selected for their excellent scientific quality and timelines, provision of good networking activities for all participants and speaker gender diversity (at least 40% of speakers must be from the underrepresented gender). Organisers are encouraged to implement measures to make the meeting environmentally more sustainable.Upon registration - More info and registration on the EMBO website.

On Thursday May 30, for our last Chill&Sciences of the season, Candy Sonvaux and Alexis Coyette, mathematics researchers, invite you to discover the mathematics where the movements of the planets and the spread of viruses intertwine until they impact our society.Chill&Science: enriching encountersWith nearly 20 years' experience of scientific cafés, the Confluent des Savoirs has set up a new concept of scientific encounters. The Chill&Sciences are a unique opportunity for the public to come and discuss and ask questions of experts on research topics related to current affairs and citizen issues.Come and enjoy the unique, relaxed atmosphere of Quai22. Researchers and experts from the seven faculties of the University of Namur will present their research and discuss with you over a drink (or two, but never without exaggeration).In practiceThe meetings are open to everyone aged 16 and over. Evenings are limited to around 20 people to ensure a relaxed atmosphere and to facilitate discussions. Meetings take place if a minimum of 10 people are registered. Except in exceptional circumstances, meetings take place every 2 months at the University of Namur's cultural space, Quai22, located at n°22 Rue du Séminaire.Tarif Participation in a Chill&Sciences costs 5€. A discounted annual pass is available. Please note: preferential rate for students (discount code: PromoCDS).The booking fee includes a drink* (soft or beer), a snack (chips and cookies) and management fees linked to the organization Unless cancelled by us, bookings are non-refundable. (*additional drinks will be available upon electronic payment.)

Characterization of trehalase from Acyrthosiphon pisum for the design of new insecticides SummaryAphids are major pests in agriculture, causing direct damage to plants and acting as vectors for phytopathogenic viruses. Conventional insecticides are widely used to control them, but their toxicity and efficacy pose problems in terms of the environment, human health and the emergence of resistance to these compounds. New alternatives are therefore needed, such as biological control using predators or parasitoids. However, these methods are not always economically viable on a large scale. As part of this thesis, another approach is being explored which involves developing new insecticides targeting the biochemical functions of aphids.The project aims to discover new inhibitors of trehalase, an enzyme essential for insect energy metabolism. Inhibition of this enzyme could disrupt vital insect functions without affecting mammals. This research involved several stages: the purification and complete characterization of trehalase from Acyrthosiphon pisum (the model for this study), the in vivo, in vitro and in silico analysis of commercial inhibitors on this enzyme, before moving on to the search for new inhibitors. Two points of integrated insect management were explored, biological and chemical control.The biological side saw the study of a strain of Streptomyces naturally producing trehalase-inhibiting metabolites, notably validamycin A, a molecule recognized in the literature as one of the best inhibitors, but not applicable as an insecticide. Other molecules appear to have interesting features, but we have not been able to isolate and characterize them.The chemical side has enabled us to create a pharmacophore hypothesis based on experimental results on molecules obtained by virtual screening. Although these molecules are not usable as insecticides as they stand, this hypothesis provides a better understanding of trehalase inhibitors in general and can be used to refine future analyses. JuryProf. Jean-Yves MATROULE (UNamur), presidentDr Catherine MICHAUX (UNamur), promoter and secretaryProf. Frédéric FRANCIS (ULiège), co-promoterProf. André MATAGNE (ULiège)Dr Rudy CAPARROS (ULiège)Dr Morgan HANS (Biocidal)

Thesis subject Use of BioID within mitochondria: examples with the study of human mitochondrial co-translational import process and with the identification of MPV17 function Summary This thesis was divided into two different parts dedicated to the study of a mitochondrial process and of a mitochondrial protein using a proximity labelling assay called BioID. The first project was dedicated to the study of a poorly characterized process, the mitochondrial co-translational import. In this process, translation is coupled to the translocation of the mitochondrial proteins, alleviating the energy cost typically associated with the post-translational import relying on chaperone systems. However, the mechanisms are still unclear with only few actors identified but none that have been described in mammals yet. We thus profiled endogenously the TOM20 proxisome using BioID. Despite the enrichment of RNA binding proteins in the TOM20 proxisome, we could not demonstrate a role for a selected candidate, LARP4, in the mitochondrial co-translational import process. Nonetheless, additional uses of this BioID cell line were highlighted such as the monitoring of protein entry inside mitochondria and a potential application in the prediction of mitochondrial protein half-life.The second project was dedicated to the study of MPV17, a protein of the inner mitochondrial membrane whose gene is associated with mitochondrial DNA depletion syndrome. However, the exact molecular function of the protein is still unclear. The approach used in this project was to identify the interacting partners of MPV17, using BioID, to get additional clues about the protein function. In this project we demonstrated an interaction of MPV17 with the MICOS complex but the KO of MPV17 didn't impact mitochondria ultrastructure. However, the depletion of MPV17 protein led to increased mitochondria-derived vesicle formation. Therefore, we investigated a potential degradation of the mtDNA as the cause of the mtDNA depletion observed in MPV17 KO cells but, despite a higher mitophagy level in KO cells, the blockade of the lysosomal activity didn't prevent the depletion. Additional in silico analyses suggested a channel activity of MPV17 further supported by its direct interaction with the Cyclophilin D, a protein of the mitochondrial permeability transition pore. Interestingly, MPV17 KO cells also display higher level of mitochondrial calcium which would be related to the degradation of the mtDNA since the blockade of mitochondrial calcium entry prevents the depletion. We thus propose a role of MPV17 as a potential new member of the mitochondrial permeability transition pore whereas in the absence of the protein, the build-up of calcium inside the mitochondria would lead to the observed mtDNA degradation. Jury Prof. Benoît MUYLKENS (UNamur), ChairmanProf. Patsy RENARD (UNamur), Promoter and SecretaryProf. Thierry ARNOULD (UNamur), Co-PromoterProf. Dr. David PLA-MARTIN (Heinrich Heine University Düsseldorf, Germany)Dr. Timothy WAI (Institut Pasteur Paris, France)Prof. David PLA-MARTIN (Heinrich Heine University Düsseldorf, Germany)Dr. Timothy WAI (Institut Pasteur de Paris, France)Prof. Guy LENAERS (Université d'Angers, France)Prof. Sven EYCKERMAN (Universiteit Gent)

On March 24, 2024, the tenth edition of the MT180 competition, a French-language competition for the popularization of science, took place at UNamur. Two physicists and a geographer represented our university at the national final, held in Brussels on May 16.