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Program 8:50 | Welcome, registration, and poster setup9:20 | Welcome speechFirst morning session 9:30 | Vladimir N. Uversky - University of South Florida, USA - "Dancing protein clouds: strange biology and chaotic physics of intrinsically disordered proteins" 10:15 | Marie Skepö - Lunds Universitet, Sweden - "Structural and conformation properties of IDPs: computer simulations in combination with experiments" 11:00 | Coffee breakSecond morning session11:30 | Peter Tompa - Vrije Universiteit Brussel, Belgium - "Fuzzy interactions of IDPs driving biomolecular condensation"12:15 | Sonia Longhi - Aix-Marseille Université, France - "Intrinsic disorder, phase transitions, and fibril formation by the Henipavirus V and W proteins"13:00 | Lunch and poster sessionAfternoon session14:30 | Sigrid Milles - Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Germany - "Intrinsically disordered proteins in endocytosis: an NMR and single molecule fluorescence perspective"15:15 | Jean-François Collet - Université Catholique de Louvain, Belgium - "How disorder controls the transport of lipoproteins in the cell envelope of Gram-negative bacteria" 16:00 | Closing speech16:10 | Networking Beer Time at "Le Chapitre"VenueUniversity of Namur, auditorium Pedro Arrupe (PA02), rue de Bruxelles, 65-67 - 5000 Namur (#21 on the campus map) Download the programme (PDF) Download the campus map Registration guidelines Registration feeStudents (PhD students included): 25 €Seniors: 40 €Payment - Bank transferPayable before 6 December on the account:Name: Université de Namur - ASBLIBAN: BE10 2500 0740 2704BIC: GEBABEBBPlease mention your name/CPO4136330 /e-mail in the payment communication. Abstract guidelines Send us your abstract before 6 December by email: pdid.meeting@unamur.beFormat: Word document, maximum 1 page A4, Times New Roman  Registration All deadlines (registration, payment, abstracts) : 6 December 2024

Dear teachers, We are pleased to invite you to a unique educational experience at the Antoine Thomas Astronomical Observatory. Offer your students the opportunity to discover the Antoine Thomas Astronomical Observatory, an observatory built on the very site where the Jesuit fathers established their own observation, training and research dome in the 19th century. Located in downtown Namur, in the heart of the university, our observatory is equipped with state-of-the-art instruments, for both night-time and daytime observation, with one of Belgium's largest solar telescopes. A visit to the observatory allows you to discover how astronomy is practiced today and - weather conditions permitting - to observe the sun in complete safety. Plan your visit today! To organize a school visit, please complete the registration form available on our website. Practical information:Guided tour 1ère to 6ème secondaire 1:30 pm to 2:30 pm or 3:00 pm to 4:00 pm Faculty of Medicine - Place du Palais de Justice, Namur Gratuit - Sur inscription The observatory is not accessible to people with reduced mobility Next date:February 11, 2025This activity is organized with the support of Wallonie Recherche. Visit registration

Dear teachers, We are pleased to invite you to a unique educational experience at the Antoine Thomas Astronomical Observatory. Offer your students the opportunity to discover the Antoine Thomas Astronomical Observatory, an observatory built on the very site where the Jesuit fathers established their own observation, training and research dome in the 19th century. Located in downtown Namur, in the heart of the university, our observatory is equipped with state-of-the-art instruments, for both night-time and daytime observation, with one of Belgium's largest solar telescopes. A visit to the observatory allows you to discover how astronomy is practiced today and - weather conditions permitting - to observe the sun in complete safety. Plan your visit today! To organize a school visit, please complete the registration form available on our website. Practical information:Guided tour 1ère to 6ème secondaire 1:30 pm to 2:30 pm or 3:00 pm to 4:00 pm Faculty of Medicine - Place du Palais de Justice, Namur Free - On registration The observatory is not accessible to people with reduced mobility This activity is organized with the support of Wallonie Recherche. Visit registration

Depuis son inauguration en 2019, l’observatoire astronomique de l’UNamur a déployé un programme pédagogique et de médiation scientifique ouvert à toutes et à tous, avec l’ambition de faire découvrir les sciences par le prisme de l’observation des merveilles du ciel. 5 ans plus tard, le pari est réussi ! La petite équipe qui anime les lieux multiplie les collaborations et les activités proposées aux étudiantes et aux étudiants, aux écoles et au grand public. Cet automne, l’Observatoire astronomique célébrera l’empreinte durable qu’il a construite dans les yeux et les cœurs de son public en fêtant son 5e anniversaire. Une occasion de rassembler la communauté qui s’est développée autour de ses projets passés, présents et futurs ! The program 11am-4pm: Tours of the observatoryUNamur - Faculté des sciences12pm-6pm: Opportunity to visit the Stellar Scape exhibitionLe Pavillon de la Citadelle de Namur6:30pm: Academic session and receptionUNamur - Faculty of Science (S01) Requested registration via ticketweb: https://www.billetweb.fr/5-ans-de-lobservatoire-antoine-thomas

JuryProf. Régis HALLEZ (UNamur), PresidentProf. Jean-Yves MATROULE (UNamur), SecretaryDr. Rob VAN HOUDT (SCK CEN)Dr. Kristel MIJNENDONCKX (SCK CEN)Prof. Liselot DEWACHTER (UCLouvain)AbstractThe viable-but-nonculturable (VBNC) state is a type of bacterial dormancy triggered by sublethal stress, where cells remain intact but lose the ability to grow on standard media. This poses challenges for microbial monitoring and public health, as VBNC cells can evade detection and might regain virulence upon resuscitation. Copper compounds are explored as antimicrobial agents, however sublethal Cu concentrations were shown to induce the VBNC state in certain bacteria. This thesis investigates the Cu-induced VBNC state in Cupriavidus metallidurans, a metal-resistant betaproteobacterium, and examines the involvement of its Cu resistance determinants (CRDs). While resuscitation is usually mediated by external factors, we aimed to uncover intrinsic processes that enable spontaneous resuscitation, a rare phenotype lacking mechanistic understanding. Proteomic analysis revealed that expression of CRDs, among others, correlated with mitigated dormancy. Time-resolved profiling showed that VBNC cells exhibit highly dynamic proteomes: VBNC entry involved oxidative stress response, and resuscitation correlated with metabolic reconstitution and the strong induction of periplasmic CRDs. Temporal clustering corroborated the explored proteomic modifications. Through mutational studies we identified the plasmid-encoded copAB system as the minimal resuscitation factor, where integrity of the CopA methionine-rich domain proved critical. ICP-MS analysis indicated that detoxification relies on Cu sequestration rather than export. Altogether, this work uncovers key intrinsic factors and proposes a mechanistic basis for spontaneous resuscitation from the Cu-induced VBNC state in C. metallidurans. These insights refine our understanding of the VBNC state as a dynamic survival strategy and of bacterial Cu resistance.

JuryDr Luca FUSARO (UNamur), PresidentProf. Carmela APRILE (UNamur), SecretaryProf. Francesco GIACALONE (University of Palermo)Prof. Paolo PESCARMONA (University of Groningen)Prof. Michelangelo GRUTTADAURIA (University of Palermo)AbstractThis PhD research focused on the design, synthesis, and catalytic evaluation of novel materials based on metal phthalocyanines (MPCs) and imidazolium bromide salts. The initial materials were extensively characterized using a wide range of analytical, spectroscopic, and spectrometric techniques, including solid-state NMR, XPS, TEM, EDX, FT-IR, Raman, CHN analysis, ICP-OES, N₂ physisorption, and TGA. These systems showed remarkable performance in promoting the cycloaddition of CO₂ to epoxides to form cyclic carbonates. Building on these results, a new class of catalysts was developed by covalently anchoring metal phthalocyanines and imidazolium salts onto multi-walled carbon nanotubes (MWCNTs), yielding materials denoted as MPC@MWCNTs. This strategy enabled the creation of a versatile family of catalysts-prepared with different metal centers (Al, Mg, Fe, Ni, Co, Cu, Zn)-while maintaining a unified synthetic approach. The incorporation of MWCNTs was aimed at enhancing both catalytic activity and stability through synergistic support effects. The resulting MPC@MWCNTs were successfully applied in diverse catalytic contexts: CO₂ valorization into cyclic carbonates (Mg-, Fe-, Cu-, and Zn-based systems), nitro-reduction reactions to afford amines (Fe-based system), and electrocatalytic methanol oxidation for energy-related applications (Ni-based system). Overall, this work demonstrated the potential of MPC@MWCNT hybrid materials as robust, tunable, and multifunctional catalysts for sustainable chemical transformations. Attend the event remotely (Teams)

JuryDr. Nikolai TUMANOV (UNamur), PresidentProf. Bao-Lian SU (UNamur), SecretaryProf. Yann GARCIA (UCLouvain)Prof. Teng BÊN (Jinhua University)Prof. Guillaume BERIONNI (UNamur)Prof. Alain KRIEF (UNamur)Prof. Alain KRIEF (UNamur)AbstractPorous crystals with structural flexibility are difficult to realize because flexible molecules often rearrange or leave the lattice, leading to pore collapse. Since the early 2000s, it has become clear that combining robust intermolecular interactions with flexible linkers and deformable nodes can stabilize porous crystals during guest removal. Frameworks such as MOFs, COFs, and HOFs benefit from strong noncovalent interactions, yet permanently porous HOFs remain uncommon due to dense molecular packing.Porous organic salts (POSs) offer an alternative strategy, assembling predictable networks from oppositely charged organic ions where electroneutrality and stoichiometry guide structure formation. However, most 3D POSs rely on planar guanidinium or tetrahedral tetraphenylmethane derivatives, resulting in a narrow set of topologies compared with the thousands of 3D nets catalogued in the Reticular Chemistry Structure Resource (RCSR).Here we report triptycene-based ionic frameworks (TIFs) formed via charge-assisted ammonium-sulfonate hydrogen bonding. By tuning triptycene symmetry and functionalization, together with sulfonate linker geometry, we generated diverse supramolecular architectures with tailored porosity, stability, and function.

JuryProf. Guillaume BERIONNI (UNamur), PresidentProf. Stéphane VINCENT (UNamur), SecretaryProf. Carmen GALAN (University of Bristol)Dr. Louis FENSTERBANK (Collège de France)Prof. Raphaël ROBIETTE (Université catholique de Louvain)AbstractCarboxylic acids are ubiquitous in nature and inexpensive compounds. Decarboxylation has become a key chemical transformation and has been widely reported in organic chemistry except for carbohydrates. This reaction can be catalyzed by transition metal and can also be induced by light, thermal activation, or photocatalysis. Borylated compounds have stimulated the pharmaceutical industry's interest (Boromycin, Bortezomib or boron neutron capture therapy). Recent methodologies have been developed to transform carboxylic acids to boronate esters by metal-catalyzed or light-promoted or photocatalyzed reactions. In this thesis, we explored the synthesis of borylated carbohydrates through a decarboxylation pathway. More specifically, sialic acids being among the most important carbohydrates in glycobiology, we addressed the problem of the synthesis of borylated sialic acids. On the other hand, organophosphates play an important role in diverse fields: in materials chemistry, in agriculture, in organic chemistry, and in biochemistry. Phosphorylation is a key reaction in biological processes such as signal transduction and cell activity regulation. The formation of phosphorylated carbohydrates has been widely described through two-electron mechanisms. However, radical phosphorylation of carbohydrates remains unexplored. This Ph.D. thesis describes the development of new methodologies for the decarboxylative functionalization of carbohydrates, focusing on borylation and phosphorylation..

JuryProf. Eli THORÉ (UNamur), PresidentProf. Patrick KESTEMONT (UNamur), SecretaryProf. Ranjàna RANDRIANARIVO (Université d'Antananarivo)Dr. Valérie CORNET (UNamur)Dr. Omayma MISSAWI (UNamur)Prof. Catherine MOUNEYRAC (Université Catholique de l'Ouest)Prof. Gauthier EPPE (ULiège)SummaryThe widespread production and use of plastics have led to their continuous release into the environment. Microplastics (MPs) are now ubiquitous in aquatic ecosystems, where their bioavailability to organisms and potential entry into the food web raise serious environmental and public health concerns. Substantial progress has been made in understanding MP toxicity, and their hazardous potential is now widely acknowledged. However, MP toxicity studies remain complex, as multiple particle characteristics, such as size, shape, polymer type, and sorbed contaminants might influence both bioavailabilityTo bridge this gap, the present thesis adopted a dual, complementary approach: (i) characterizing the environmental occurrence and bioavailability of MPs, and (ii) assessing the ecological relevance of using environmentally derived MPs in in vivo toxicity experiments.Overall, this thesis provides insights into the reproductive and transgenerational effects of environmentally relevant MPs while underscoring the importance of considering particle-pollutant interactions. By combining in situ field data with in vivo laboratory experiments, it demonstrates that the use of environmentally derived MPs represents a more realistic and ecologically meaningful approach to hazard characterization. Further studies should be carried out in this same perspective to generate robust, exploitable data and contribute to establishing a comprehensive MP risk characterization.

JuryProf. Nicolas DENDONCKER (UNamur), PresidentProf. Sabine HENRY (UNamur), SecretaryDr. Sébastien DUJARDIN (UNamur)Prof. Pierre OZER (ULiège)Prof. Emmanuel TWARABAMENYE (University of Rwanda)Prof. Caroline MICHELLIER (MRAC and UCLouvain)AbstractThis research investigates community vulnerability to landslides and floods in Northwestern Rwanda, hazards that frequently interact to produce compound disasters. The research focused on understanding the institutional, social, and structural factors that shape vulnerability and adaptive capacity in this disaster-prone region. Using a mixed-methods approach at local-scale, including institutional analysis, household surveys (n = 904), and field observations, the research highlights how vulnerability is shaped by socio-economic conditions, weak institutional coordination, and limited adaptive capacity. A Contextualized Vulnerability Index (CoVI) was developed to map vulnerability patterns, revealing particularly high vulnerability in landslide-prone and dual-hazard zones. The analysis of adaptive capacity showed that while awareness of hazards is high due to lived experiences, financial constraints, and limited technical knowledge hinder communities' ability to adapt effectively. The study contributes to the literature on social vulnerability and disaster risk reduction by emphasizing the importance of locally grounded, evidence-based strategies to strengthen community resilience in hazard-prone regions.

Abstract Since its emergence in 1996, the Asian H5 Goose/Guangdong (Gs/Gd) lineage has circulated widely in poultry in southern China, spilling over to wild birds by 2002. Wild bird infections facilitated global dissemination via migratory waterfowl and repeated spillback into poultry, challenging the view that HPAI primarily arises from LPAI mutation. Subclade 2.3.4.4b emerged in Asia in 2013, reached Europe in 2016, caused recurrent epizootics, diversified into multiple genotypes, became dominant in wild birds, and shows zoonotic potential.This thesis investigates critical knowledge gaps regarding H5Nx subclade 2.3.4.4b in poultry: (1) early within-flock spread after punctual introduction in chickens, particularly during the first European epizootics; (2) influence of pre-existing immunity on silent circulation; (3) limitations in diagnostic throughput during epizootic peaks; (4) potential of environmental surveillance, including air and dust sampling; and (5) impact on egg contamination and the reproductive tract, relevant for food safety and zoonotic risk.Four main objectives were addressed: (1) development of an experimental model simulating punctual introductions and spread, comparing 2017 and 2020 strains and assessing pre-existing immunity; (2) enhancement of diagnostic capacity via alternative sampling, semi-automated RNA extraction, and high-throughput processing; (3) evaluation of air and dust sampling for virus monitoring under experimental and field conditions; and (4) assessment of egg contamination risk. Alternative sampling and environmental monitoring were also applied to Newcastle disease virus as a comparative notifiable pathogen. Jury Prof. Catherine LINARD (UNamur), ChairProf. Benoît MUYLKENS (UNamur), SecretaryDr. Damien COUPEAU (UNamur)Dr. Jean-Luc GUÉRIN (INRAE & ENVT)Dr. Cyril BARBEZANGE (ECDC)Dr. Steven VAN BORM (Sciensano)Dr. Mieke STEENSELS (Sciensano)Dr. Bénédicte LAMBRECHT (Sciensano)

JuryProf. Nicolas DENDONCKER (UNamur), ChairProf. Sabine HENRY (UNamur), SecretaryProf. Frédéric SILVESTRE (UNamur)Dr. Sébastien DUJARDIN (UNamur)Prof. Kara PELLOWE (Stockholm University)Prof. Romain GLELE KAKAI (University of Abomey Calavi)Prof. Patrick KESTEMONT (UNamur)Prof. Eli THORE (UNamur)AbstractMangroves play an important role in environmental conservation and livelihood provision yet remain one of the most threatened ecosystems on earth. This doctoral study assesses pathways to enhance coastal sustainability in the Anthropocene, by promoting the sustainable use of mangroves and strengthening their social-ecological resilience through an interdisciplinary approach. The thesis is structured into four specific objectives: assessing the role of traditional beliefs and local deities in promoting the sustainable use of mangroves, analyzing the synergies between legal frameworks and traditional beliefs in enhancing the social-ecological resilience of mangroves, developing a novel interdisciplinary framework to evaluate the social-ecological resilience of mangroves, and operationalizing the proposed framework in Benin's mangroves, West Africa.  We collected field data using ethnobiological surveys, drone image analysis and document review, in-depth interviews, focus group discussions, plant and fish inventories across three coastal communities in Benin. The study draws insights from the seven principles of resilience to analyze mangrove sustainability. The interdisciplinary methodology of this study links plant biology, fisheries sciences, and human geography to analyze mangroves as complex social-ecological systems. Findings of the thesis show that traditional beliefs and local deities play a significant role in regulating the use of mangrove resources, while the overlapping of formal and informal institutions offer opportunities to enhance their social-ecological resilience. The novel proposed framework called Mangrove Social Ecological Resilience Appraisal (MaSERA) outlines variables and indicators tailored to mangroves to assess their social-ecological resilience. Its application in Benin highlights its potential in identifying factors that enable or erode mangrove resilience, for informed decision making. The study argues that promoting the sustainable use of mangroves and enhancing their social-ecological resilience represent dual imperatives for achieving coastal sustainability in the Anthropocene. It contributes to the growing body of knowledge on mangrove conservation and provides actionable insights for integrated coastal zone management.