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phot_kevin.pngKévin Renault

Researcher

Tel: +32 (0)81 72 54 18

 

 

 

 

 

Bibliographical sketch:

Kévin obtained a Ph. D. thesis in organic chemistry in 2018 from Normandie université in Rouen (France) under the co-direction of Dr. Cyrille Sabot and Prof. Pierre-Yves Renard in COBRA laboratory. This thesis is entitled “Development of chemoselectives ligations “click”- application to the synthesis of fluorogenic probes”.

From 2019 to 2021, he obtained a post-doctoral position at ICMUB laboratory at the Burgundy university, Dijon (France), under the supervision of Prof. Anthony Romieu. He worked on the development of new fluorogenic probes based on covalent assembly principle for enzymes detection. 

Since September 2021, he started a post-doctoral position in the laboratory of Chimie Bio-Organique (CBO) under the supervision of Prof. Stéphane Vincent at the University of Namur. This research project concerns the development of methodology to synthesized fluorinated sugar derivate.

 

Research activities:

K. Renault, A. Chevalier, J. Bignon, D. Jacquemin*, J.-A. Richard, A. Romieu. Coumarin-Pyronin Hybrid Dyes: Synthesis, Fluorescence Properties and Theoretical Calculations. ChemPhotoChem, 2021, 5, 822-838, DOI: 10.1002/cptc.202100069.

K. Renault, S. Debieu, J.-A. Richard, A. Romieu. Deeper insight into protease-sensitive “covalent-assembly” fluorescent probes for practical biosensing applications. Org. Biomol. Chem. 2019, 17, 8918-8932. DOI: 10.1039/C9OB01773A.  

K. Renault, C. Guillou, P.-Y. Renard, C. Sabot. Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules. Org. Biomol. Chem. 2019, 17, 388-396. DOI: 10.1039/C8OB02108B.

K. Renault, P.-Y. Renard, C. Sabot. Detection of Biothiols with a Fast-Responsive and Water-Soluble Pyrazolone-Based Fluorogenic Probe. Eur. J. Org. Chem. 2018, 2018, 6494-6498. DOI: 10.1002/ejoc.201801157.

K. Renault, P.-Y. Renard, C. Sabot. Photophysical properties of quinoxalin-2(1H)-ones: application in the preparation of an azide-based fluorogenic probe for the detection of hydrogen sulfide. New J. Chem. 2017, 41, 10432–10437.                 DOI: 10.1039/C7NJ01893B.

K. Renault, L.-A. Jouanno, A. Lizzul-Jurse, P.-Y. Renard, C. Sabot. Fluorogenic Behaviour of the Hetero-Diels-Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications. Chem. - Eur. J. 2016, 22, 18522-18531. DOI: 10.1002/chem.201603617.

K. Renault, C. Sabot*, P.-Y. Renard. Fast-Responsive Nitroso-Based Turn-On Probe for Hydrogen Sulfide: Nitroso-Based Turn-On Probe for Hydrogen Sulfide. Eur. J. Org. Chem. 2015, 2015, 7992–7996. DOi: 10.1002/ejoc.201501140.

K. Renault, J.W. Fredy, P.-Y. Renard, C. Sabot. Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies. Bioconjugate Chem. 2018, 29, 2497–2513. DOI: 10.1021/acs.bioconjchem.8b00252