Sujets de recherche
Sujet A - La tuberculose
Des nouvelles stratégies pour soigner la tuberculose: Vers l'inhibition et les études méchanistiques de la biosynthèse du galactofuranose.(1)
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(1a) J. Fu, H. Fu, M. Dieu, I. Halloum, L. Kremer, Y. Xia, W. Pan, S. P. Vincent Chem. Commun. 2017, 53, 10632−10635.
(b) S. Villaume, J. Fu, I. N’Go, H. Liang, H. Lou, L. Kremer, W. Pan, S. P. Vincent Chem. Eur. J. 2017, 23, 10423−10429.
(c) C. Frédéric, A. Tikad, J. Fu, W. Pan, R. B. Zheng, A. Koizumi, X. Xue, T. L. Lowary, S. P. Vincent Chem. Eur. J. 2016, 22, 15913−15920.
(e) K.E. van Straaten, C.M. Sevrain, S.A. Villaume, J. Jiménez-Barbero, B. Linclau, S.P. Vincent, D.A.R. Sanders J. Am. Chem. Soc. 2015, 37, 1230−1244.
(f) S. El Bkassiny, I. N’Go, C.M. Sevrain, A. Tikad, S.P. Vincent Org. Lett. 2014, 16, 2462−2465.
(g) I. N’Go, S. Golten, Ana Ardá, J. Cañada, J. Jiménez-Barbero, B. Linclau, S.P. Vincent Chem. Eur. J. 2014, 20, 106−112.
Sujet B - Glycoclusters
Les Glycofullerènes comme inhibiteurs de glycosyltransférases et comme molécules empêchant l'adhésion des bactéries.(2)
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A giant fullerene system inhibits the infection by an artificial Ebola virus (Picture realized by JF Nierengarten) |
Fullerene sugar balls |
(2a) B.J.J. Timmer, M. Abellan Flos, L. Monster Jorgensen, D. Proverbio, S. Altun, O. Ramstrom, T. Aastrup, S.P. Vincent Chem. Commun. 2016, 52, 83, 12326−12329.
(b) M. Durka, K. Buffet, J. Iehl, M Holler, J.-F. Nierengarten, J. Taganna, J. Bouckaert, S.P. Vincent Chem. Commun. 2011, 47, 1321−1323.
(c) J.-F. Nierengarten, J. Iehl, V. Oerthel, M Holler, B.M. Illescas, A. Muñoz, N. Martín, J. Rojo, M. Sánchez-Navarro, S. Cecioni, S. Vidal, K. Buffet, M. Durka, S.P. Vincent Chem. Commun. 2010, 46, 3860−3862.
(d) M. Durka, K. Buffet, J. Iehl, M Holler, J.-F. Nierengarten, S.P. Vincent Chem. Eur. J. 2012, 18, 641−651.
Topic C - Antivirulence
Synthesis of inhibitors of the LPS (lypoPolySaccharide) biosynthetic pathway: towards antivirulence molecules.(3)
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(3a) A. Tikad, H. Fu, C. Sevrain, S. Laurent, J.-F. Nierengarten, S.P. Vincent Chem. Eur. J. 2016, 22, 13147−13155.
(b) M. Durka, A. Tikad, R. Périon, M. Bosco, M. Andaloussi, S. Floquet, E. Malacain, F. Moreau, M. Oxoby, V. Gerusz, S.P. Vincent Chem. Eur. J. 2011, 17, 11305−11313.
(c) H. Dohi, R. Périon, M. Durka, M. Bosco, Y. Roué, F. Moreau, S. Grizot, A. Ducruix, S. Escaich, S. P. Vincent Chem. Eur. J. 2008, 14, 9530−9539.
Topic D - Biosensor for detection (FRISBY project)
Fast and Reliable ultra-sensitive Identification of Streptococcus B at deliverY (FRISBY).
The FRISBY project aim to develop a ultra-sensitive detector of Streptococcus B in collaboration with Coris BioConcept, Lambda-X, the Hospital Center of Liege and the University of Liege.
