Valentin Bochatay

Research fellow

Tel: +32 (0)81 72 45 17
valentin.bochatay@unamur.be

Bibliographical sketch:

Valentin BOCHATAY received his Master’s degree in Synthetic Organic Chemistry from the Université Pierre et Marie Curie (Sorbonne Université, Paris, France) in 2013. He then started his doctoral studies in Organic and Organometallic Chemistry under the supervision of Pr. Franck FERREIRA and Pr. Fabrice CHEMLA at the "Institut Parisien de Chimie Moléculaire". During that period he studied the reactivity of allenylmetals (Zinc, Copper, Boron and Silicium) using different kinds of electrophiles such as SelectFluor®. He got his PhD in 2016.

In October 2017, he obtained a position at UNamur as postdoctoral fellow with Pr. Stéphane VINCENT and worked on several projects such as the FRISBY project (Fast and Reliable ultra-sensitive Identification of Streptococcus B at deliverY) which aim to develop a ultra-sensitive detector of Streptococcus B in collaboration with Coris BioConcept and the University of Liege. In parallel, he worked within the main activity of the laboratory, the Glycochemistry.

Since September 2019 he works in Lyon, France, as a consultant for research and innovation funding.

Research activities:

- Org. Lett. 2019, 21, 14, 5562−5566. "Regioselective Synthesis of Difluorinated C‑Furanosides Involving a Debenzylative Cycloetherification" 

- Eur. J. Org. Chem. 2018, 3862−3866. "β‐Amino Propargylic Fluorides through Stereoselective Electrophilic Fluorodesilylation of 4‐Amino‐1‐allenylsilanes"

- C. R. Chimie 2017, 20, 609−616. “Synthesis of allenylzinc reagents by 1,2-rearrangement of alkynyl(disilyl)zincates derived from acetylenic epoxides and acetylenic aziridines”

- Synthesis 2016, 48, 3287−3300. “4-Amino-1-allenylsilanes from 4-Aminopropargylic Acetates through a Silylzincation/Elimination Sequence”

- Adv. Synth. Catal. 2015, 357, 2809−2814. “Ring-Opening of N-tert-Butanesulfinylethynylaziridines with Lithium Tris(dimethylphenylsilyl)zincate: Stereoselective Access to 4-Amino-1-allenylsilanes”

- J. Org. Chem. 2013, 78, 1471−1477. “Mechanistic Exploration of the Palladium-catalyzed Process for the Synthesis of Benzoxazoles and Benzothiazoles”

Technical report (case study):

- Science of Synthesis 2016. “Analysis of synthetic routes toward allenylsilanes”

Arnaud Bomans

Master student

Tel: +32 (0)81 72 45 17
arnaud.bomans@student.unamur.be

Bibliographical sketch:

Arnaud BOMANS obtained his bachelor's degree in chemistry at the University of Namur in 2020. For his master's thesis, he is currently working on the synthesis of the lactate racemase cofactor. This project is supervised by Doctor Timothé Vucko.

Jun cao

PhD Student

Tel: +32 (0)81 72 45 17
jun.cao@unamur.be

Bibliographical sketch:

Jun CAO received her Master’s degree in “Medicinal Chemistry” from the Guizhou Medical University (Guizhou, China) in 2018. During that time, she was worked on metal catalysis and synthesis of berberine derivatives.
In October 2018, she started as a doctoral student under the supervision of Professor Stéphane Vincent study in Bioorganic Chemistry at “University of Namur”. She is currently working on “Synthesis of Novel Heptose Derivatives as Antibacterial Agents”.

Research activities:

alexis caudron

Master student

Tel: +32 (0)81 72 54 18
alexis.caudron@student.unamur.be

Bibliographical sketch:

Alexis CAUDRON obtained his Bachelor degree in Chemical Sciences in June 2018 at the University of Namur. As a Master intern, he is currently working on the synthesis of sugar derivatives, used by β-D-galactosidases, containing a fluorescent probe. The purpose of this synthesis is to study the role of the enzyme by fluorescence microscopy. This master thesis is done under the supervision of Loïc CHENE.

lea chartier

PhD student

Tel: +32 (0)81 72 45 17
lea.chartier@unamur.be

Bibliographical sketch:

Léa Chartier received in 2018 her engineering degree in chemistry, with the major "Life Chemistry and Technology" and a specialization in advanced organic chemistry, from the Ecole Nationale Supérieure de Chimie de Rennes (France). The same year she graduated from the University of Rennes (France) with a Master's degree in Molecular Chemistry.
In November 2018 she started a PhD in the CBO unit under the supervision of Pr. Stéphane Vincent (UNamur) and Riccardo Marega (CER). Her PhD research field is on the development of new technologies for antibodies functionalization. Thus this is a project at the interface between  bio-chemistry (with  antibodies generation, functionalization and immunoaffinity characterisation) and organic synthesis (with the synthesis of sugar as molecular tools to functionalize the antibodies).

Research activities:

wenzhang chen

PhD student

Tel: +32 (0)81 72 54 18
chenwenzhang@unamur.be

Bibliographical sketch:

Wenzhang CHEN received his Master’s degree in “Medicinal Chemistry” from the Guizhou Medical University (Guizhou, China) in 2015. Then, he worked as a teaching assistant in the same university from 2015 to 2017. He studied the design and synthesis of functionalized natural product derivatives, including cajanonic acid A, Longistylin C, BPN and cantharidin.
On November 2017, he started his Ph.D tilted “The synthesis of novel antibacterial glycoclusters” at UNamur.

Research activities:

Wen-zhang Chen, Ling-Ling Fan, Lei Tang et al. First total synthesis of natural products cajanolactone A and cajanonic acid A. Chinese Chemical Letters. 2014, 25(5),749-751.

Wen-zhang Chen, Cong Wang, Lei Tang et al. Total Synthesis of Longistylin A, Longistylin C and Cajanotone. Chinese Journal of Organic Chemistry. 2015, 35(5), 1146-1151

Wen-zhang Chen, Wan Xiao, Ling-Ling Fan, Lei Tang. Improved Synthesis of Cajanonic Acid A. Chemical Reagents. 2015, 37(2), 165-167.

Wen-zhang Chen, Lei Tang, jing Xia, et al. Chinal Patent. CN 106397507 A.

loïc chene

PhD student

Tel: +32 (0)81 72 54 18
loic.chene@unamur.be

Bibliographical sketch:

Loïc CHENE received his Master degree in Synthetic Organic Chemistry from the Université de Rouen (Normandy University) in 2016. He then started his doctorate as an assistant professor in the laboratory of Stéphane VINCENT (UCO, CBO unit). His PhD work is divide in two parts, the first one is focused on bio-organic chemistry and mainly the synthesis of sugar derivatives for the charaterization of b-D-Galactosyl-Hydrolases. In parallel, he is working as an enzymologist and is carrying out all the biological tests of the laboratory (enzyme overexpression, fluorescence polarization, HPLC test,  IC50,…).

As an assistant professor he is teaching general chemistry and organic chemistry to different level students (Bachelor’s, Master’s).

Book chapter:
- “Fluorine in Life Sciences. Pharmaceuticals, Medical Diagnostics and Agrochemicals" Chapter 6: Fluorosugars as inhibitors of bacterial enzymes, 2018.

Florence Cortina

Researcher

florence.cortina@student.unamur.be

Bibliographical sketch:

Florence Cortina started chemistry studies at the University of Namur in 2018 and obtained her Bachelor’s degree in 2021. For her Master’s thesis, she is currently working on the synthesis of novel copillar[4+1]arenes conjugates. The final purpose of this project is to prevent the entry of the SARS-CoV-2 virus into host cells.

julien delbrouck

PhD student

Tel: +32 (0)81 72 41 11
julien.delbrouck@unamur.be

Bibliographical sketch:

Julien A. Delbrouck graduated from the University of Namur with a first-class honors degree in Chemistry Sciences in 2014. He worked on a multistep synthesis of C-nucleosides during his Master’s studies at Namur. He then moved to Basel for a three months internship in the pharmaceutical and early development department of Hoffmann La Roche where he worked in the field of infectious diseases.

Since october 2014, He is working toward a PhD degree under the supervision of Prof. Stéphane Vincent (UNamur), with research in the field of bio-organic chemistry. The two main project  are related to: A) the debenzylative cycloetherification reaction applied to multistep synthesis B) the preparation of new fluorinated substrates analogues of UGM, a key enzyme involved in the mycobacterium tuberculosis cell wall biosynthesis.

He obtained his PhD in November 20th, 2018.

Research activities:

- "Regioselective Synthesis of Difluorinated C‑Furanosides Involving a Debenzylative Cycloetherification" Org. Lett. 2019, 21, 14, 5562−5566.

- "Efficient and regioselective synthesis of γ-lactone glycosides through a novel debenzylative cyclization reaction" Chem. Commun. 2018, 54, 9845−9848.

- “Debenzylative Cycloetherification : An Overlooked key strategy for Complex Tetrahydrofuran Synthesis” Chem. Eur. J. 2016, 22, 9456−9476.

Book chapter:
- “Fluorine in Life Sciences. Pharmaceuticals, Medical Diagnostics and Agrochemicals" Chapter 6: Fluorosugars as inhibitors of bacterial enzymes, 2018.

Christophe frederic

PhD student

Tel: +32 (0)81 72 41 11
christophe.frederic@unamur.be

Bibliographical sketch:

Christophe Frédéric received his Master degree in Chemistry with specialization in BioOrganic Chemistry from the University of Namur in 2014. During that master, he realized an Internship (6 months) in the TSU Infectious Disease at the company Sanofi R&D in Toulouse under the supervision of Dr. A. Froidbise. He then started his doctoral studies about ‘’Multistep synthesis of functionalized exocyclic enol ethers derived from carbohydrates as potential antitubercular agents’’ in the Bio-Organic chemistry laboratory directed by Ph. Stéphane Vincent.

He obtained his PhD in December 19th, 2018.

Research activities:

- "Synthesis of exo-glycals and their biochemical applications" Tetrahedron 2018, 74, 45, 6512−6519.

- "Highly (Z)‑Diastereoselective Synthesis of Trifluoromethylated exo-Glycals via Photoredox and Copper Catalysis" Org. Lett. 2018, 20, 6769−6773.
- "Synthesis of unprecedented sulfonylated phosphono-exo-glycals designed as inhibitors of the three mycobacterial galactofuranose processing enzymes" Chem. Eur. J. 2016, 22, 15913−15920.

ravikumar jimmidi

Research fellow

Tel:
ravikumar.jimmidi@unamur.be

Bibliographical sketch:

Ravikumar Jimmidi received his Master degree in Chemistry from the Kakatiya University, Warangal, India, in 2009. He then started his doctoral studies in Organic Chemistry under the supervision of Professor Prabhat Arya at the “Dr. Reddy’s Institute of Life Sciences“, University of Hyderabad Campus, Hyderabad, India. During that time he Synthesized natrual product inspired benzofuran-derived bioactive macrocycles and Eribulin fragment-based hybrid macrocycles. He obtained his PhD in 2015. After his doctoral studies, he had one year experience in GVKBiosciences Private Limited as Associated Scientist and nine months experience in Sai Life Sciences, Hyderabad, India.

In November 2016, he obtained a position at the “Université de Namur” (Belgium), as a Postdoctoral Research fellow (FNRS) and is currently working on the glycofullerene project which is aim to mechanism studies of glycosidase inhibitors.

Research activities:
- “A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection” Cell Chem. Bio. 2017, 24, 1-14.
- “Practical Stereoselective Synthesis of Eribulin Fragment toward Building a Hybrid Macrocyclic Toolbox” Org. Lett. 2015, 17(3), 468-471.
- “Stereoselective Synthesis of Rapamycin Fragment to Build a Macrocyclic Toolbox” Org. Lett. 2015, 17(3), 480-483.
- “Selected Hybrid Natural Products as Tubulin Modulators” Eur. J. Med. Chem. 2015, 94, 497-508.
- “Small Molecule Modulators of Protein-Protein Interactions: Selected Case Studies” Chem. Rev. 2014, 114, 4640-4694.
- “Prevention of Mitochondrial Membrane Permeabilization and Pancreatic β-Cell Death by an Enantioenriched, Macrocyclic Small Molecule” Eur. J. Org. Chem. 2014, 1151-1156.

Lina liang

PhD student

Tel: +32 (0)81 72 45 17
lina.liang@unamur.be

Bibliographical sketch:

Lina LIANG received her Master degree in Medicinal Chemistry from Guizhou University (Guizhou, China). During that time, she studied the biomimetic synthesis of indolo[3,2-a]carbazoles and the total synthesis of rutaecarpine and its analogs.

In 2015, she obtained the CSC scholarship to start his doctoral study in Bioorganic Chemistry at “University of Namur”. Her objective is to synthesize a series of carbohydrates to find novel anti-bacterial agents.

Research activities:
- Lina Liang, Tian-yun Fan, Tao Huang, Sheng Liu, et al. A biomimetic access to indolo [3,2-a] carbazoles. Tetrahedron Lett. 2015, 56, 434−436.
- Lina Liang, Rui An, Tao Huang, Mei Xu, Xiao-Jiang Hao, Wei-Dong Pan*, Sheng Liu*. A simple approach for the syntheses of rutaecarpine and its analogs. Tetrahedron Lett. 2015, 56, 2466−2468.
- Lina Liang, Stéphane P. Vincent. Synthesis of D-glycero-D-manno-heptose 1,7 -bisphosphate (HBP) featuring a β-stereoselective bis-phosphorylation. Tetrahedron Lett. 2017, 58, 3631−3633.

Elise Marle

Master student

Tel: +32 (0)81 72 54 18
elise.marle@unamur.be

Bibliographical sketch:

Elise MARLE obtained her Biochemistry Bachelor degree in 2017 at the university of Lille (France) and is currently a second year master student in Chemistry and Life Sciences at the same university. As a Master intern, she is currently working on the synthesis of heptose used in the click chemistry process. This master thesis is done under the supervision of Marine LACRITICK.

tharwat mohyeldine

Research fellow

Tel:
tharwat.mohyeldine@unamur.be

Bibliographical sketch:

In 2012, Tharwat MOHY EL DINE received her Master’s degree in ‘’Synthesis, Catalysis and Sustainable Chemistry’’ from the University of Claude Bernard - Lyon 1 (UCBL) (Lyon, France). Afterwards (2013 to 2016), she finished her doctoral studies in Organic, Mineral and Industrial Chemistry at the University of Caen-Normandy (Caen, France) within the research group of Pr. Jacques Rouden at the Laboratoire de Chimie Moléculaire et Thioorganique (LCMT) with a PhD thesis entitled ‘’New Insights in Amide Bond Formation Mediated by Boron-Based Catalysts”. During her PhD, she studied the reactivity of heteroaryl boronic acids and ortho-substituted bis arylborinic acid as catalysts for mild amide, peptide and formamide syntheses.

In 2016, she got a postdoctoral position for one year at the University of British Columbia (Vancouver, Canada) under the supervision of Prof. David Perrin at The Perrin Laboratory where she has worked on the ‘’Blaz-Schiemann Reaction, Fluorination and the Synthesis of PET Imaging Agents’’. On November 2017, she started her 2nd postdoctorate (Move-in Louvain fellowship) at the “Université de Namur” (Namur, Belgium) and is currently working on the ‘’Synthesis of Novel Heterovalent Scaffolds as Antibiofilm Agents’’.

Research activities:

- "One-Pot, Solvent-Free Access to Unsymmetrical Ureas by Palladium Catalysed Reductive Alkylation Using Molecular Hydrogen" T. Mohy El Dine, S. Chapron, M.C. Duclos, N. Duguet, F. Popowycz, M. Lemaire Eur. J. Org. Chem. 2013, 5445–5454.
- "Catalytic Chemical Amide Synthesis at Room Temperature: One More Step Toward Peptide Synthesis" T. Mohy El Dine, W. Erb, Y. Berhault, J. Rouden, J. Blanchet  J. Org. Chem. 2015, 80, 4532−4544.
- "Borinic Acid Catalysed Peptide Synthesis" T. Mohy El Dine, J. Rouden, J. Blanchet, Chem. Commun. 2015, 51, 16084−16087.
- "Formamide Synthesis through Borinic Acid Catalysed Transamidation" T. Mohy El Dine, D. Evans, J. Rouden, J. Blanchet, Chem. Eur. J. 2016, 22, 5894–5898.
- "Borinic acid Catalysed Hydrosilanes Reduction of Tertiary Amides: A Mild and Chemoselective Synthesis of Amines" A. Chardon, T. Mohy El Dine, R. Legay, M. De Paolis, J. Rouden, J. Blanchet Chem. Eur. J. 2016, 23, 2005–2009.

François Pirard

Master student

francois.pirard@student.unamur.be

Bibliographical sketch

François Pirard started chemistry studies at the university of Namur in 2018. He acquired his Bachelor in 2021. As a master project, he is working on the development of Aziridines as potential inactivators of GlfH1, a glycoside hydrolase present in Mycobacterium tuberculosis.

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Thibaut rigotti

Master student

Tel: +32 (0)81 72 54 18
thibaut.rigotti@student.unamur.be

Bibliographical sketch:

Thibaut RIGOTTI received his Bachelor in Chemistry at the University of Namur in 2017.
As a master student he's currently working on synthesizing a sugar derivative used by b-D-galactosidases. This master thesis is done under the supervision of Loïc CHENE.

maha Rzeigui

Researcher

Tel: +32 (0)81 72 54 18
maha.rzeigui@unamur.be

Bibliographical sketch:

Maha RZEIGUI received her master’s degree in Computer Chemistry, Spectrometry, Analysis from the Université d’Aix Marseille in 2014, studying the purification, synthesis, oxidation, and physicochemical characterization of charybdotoxin, peptide isolated from the venom Leiurus Quinquestriatus Hebraeus of scorpion.

She then started her doctoral studies in 2016, under the supervision of Pr. Claude Taillefumier and Pr. Jameleddine Khiari, at the Institut de Chimie de Clermont-Ferrand (ICCF), at the University of Clermont-Auvergne (France). This thesis is entitled “Synthesis and structural studies of new peptoids and their conjugates with metallophthalocyanines”. Her PhD research focused on the field of peptoids (N-substituted glycine oligomers), a classe of peptidomimetics, and their conjugation with phtalocyanins.

Since May 2021, she started a post-doctoral position in the laboratory of Chimie Bio-Organique (CBO) under the supervision of Pr. Stéphane Vincent at the Université de Namur

Research activities:

Rzeigui.M.; Traikia. M.; Jouffret. L.; Kriznik. A.; Khiari. J.; Roy. O.; Taillefumier. C. J. Org. Chem. 2019, 85, 2190-2201. “Strengthening Peptoid Helicity through Sequence Site-Specific Positioning of Amide Cis-Inducing NtBu monomers”.

Rzeigui, M., Şahin, Z., Roy, O., Küçük, T., Göler, Ö., Atilla, D., Taillefumier, C. Dyes and Pigments, 2021, 189, 109095. “Peptoid-phthalocyanine architectures with different grafting positions: Synthetic strategy and photoproperties”

elsa tufenkjian

Researcher

Tel: +32 (0)81 72 54 18
elsa.tufenkjian@unamur.be

Bibliographical sketch:

Elsa TUFENKJIAN obtained a master degree majoring in catalysis, molecule and green chemistry from the University of Rennes 1 in 2015. Her master thesis was supervised by Dr. Lucie Norel and Pr. Stephane Rigaut focusing on the synthesis of luminescent and magnetic switches based on redox active ruthenium acetylide complexes or photochromic binolate lanthanide complexes. After obtaining the excellence initiatives scholarship (IdEx), she joined the International PhD Program (PDI) of the University of Strasbourg. In December 2018, she completed her PhD thesis in the lab of Molecular Tectonics under the supervision of Pr. Mir Wais Hosseini and Pr. Veronique Bulach. Her PhD thesis dealt with molecular tectonics based on porphyrin, dipyrrins, pyridines and terpyridines bearing nucleobases. Elsa is currently continuing her postdoctoral research in the University of Namur in the CBO lab (Laboratoire de chimie organique et bio-organique) under the supervision for Pr. Stéphane Vincent focusing the synthesis of novel nickel pincer cofactor, biosynthetic precursors and analogues.

Thomas Vanhosmael

Master student

Tel: +32 (0)81 72 45 17
thomas.vanhosmael@student.unamur.be

Bibliographical sketch:

Thomas Vanhosmael began his master thesis in February 2020 as a bachelor and master student in advance chemistry at the CBO and the RCO under the tutelage of Stéphane Vincent and Jun Cao (CBO) and Guillaume Berionni and Ali Ben Saida (RCO). He is currently working on two ways of enantioselective synthesis of a borated exo-glycal derived from from D-ribono-lactone, and also on their optimization: this with the aim of opening the way to bio-orthogonal chemistry with on one side a natural sugar on the other oborated alkene.

Sydney villaume

PhD student

Tel: +32 (0)81 72 54 18
sydney.villaume@unamur.be

Bibliographical sketch:

Sydney was formed as chemical engineer at the ENSCCF (now also known as Sigma, France) and obtained Master degree in Synthetic Organic Chemistry from the Université Blaise Pascal (Clermont-Ferrand, France) in 2013.

He then moved to Namur, Belgium to work as assistant in chemistry at the UNamur. He started his PhD thesis under the supervision of Pr. Stéphane Vincent in the field of medicinal chemistry. He spent his 6 years studying the inhibition of the mycobacterial cell wall of Mycobacterium tuberculosis by synthesizing new “drug-like” molecules bearing heterocycles and various functions. He also taught Organic Chemistry at the University of Namur to students (from 1st year to Master 2 levels).

He got his PhD in October 15th, 2018 with a thesis of title "Synthetic derivatives of natural polyphenols targeting the mycobacterial cell wall".

Research activities:
- Carbohydrate Chemistry: Proven Synthetic Methods, Vol 4, 2018, Chapter 11.
- Chem. Eur. J. 2017, 23, 10423–10429.
- J. Am. Chem. Soc.,2015, 137 (3), 1230–1244.

Timothé Vucko

Researcher

Tel: +32 (0)81 72 54 18
timothe.vucko@unamur.be

Bibliographical sketch:

Timothé Vucko obtained a PhD thesis in 2019, which was directed by Dr.Nadia Pellegrini-Moïse and Dr.Sandrine Lamandé-Langle, at the Laboratoire Lorrain de Chimie Moléculaire (L2CM), at the University of Lorraine, in Nancy (France). This thesis is entitled “Fluoro C-glycosides for peptides labeling. Applications in PET and dual PET/NIRF imaging”.

Since September 2020, he started a post-doctoral position in the laboratory of Chimie Bio-Organique (CBO) under the supervision of Professor Stéphane Vincent at the University of Namur. This research project concerns the synthesis of anti-bacterial nucleosides

Research activies :

Collet, C., Vucko, T., Karcher, G., Pellegrini-Moïse, N., Lamandé-Langle, S. ; Automated radiosynthesis of [¹⁸F]Fluoro-C-glyco-c(RGDfC) : exploiting all the abilities of the AllInOne synthetizer. React. Chem. & Eng., 2019, 4, 2088-2098.

Vucko, T.; Petry, N.; Dehez, F.; Lambert, A.; Monari, A.; Lakomy, C.; Regnault, V.; Lacolley, P.; Pellegrini-Moïse, N.; Lamandé-Langle, S.; C-glyco“RGD” as αIIbβ3 and αvβ3 integrin ligands for imaging applications: Synthesis, in vitro evaluation and molecular modeling”. Bioorg. Med. Chem., 2019, 27, 4101-4019.  

Vucko, T.; Pellegrini-Moïse, N.; Lamandé-Langle, S. Value-added carbohydrate building blocks by regioselectivity O-alkylation of C-glucosyl compounds. Carbohydr. Res., 2019, 477, 1-10.

Petry, N.; Vucko, T.; Collet, C.; Lamandé-Langle, S.; Pellegrini-Moïse, N.; Chrétien, F. Synthesis and Revised Stereochemical Assignment of C-Allyl Glucopyranosides and Derivatives. Carbohydr. Res., 2017, 445, 61–64.

Tao wang

PhD student

Tel:
tao.wang@unamur.be

Bibliographical sketch:

Tao WANG received his Master`s degree in “Medicinal Chemistry” from the University of Guizhou in 2012. In 2013, he worked as a lecturer at the School of Pharmaceutical Engineering of Guizhou Institute of Technology. In 2016, he started his PhD titled “Novel Multivalent Molecules as Antibiofilm and Antibacterial Agents” at the University of Namur under the supervision of Professor Stéphane VINCENT  in the research unit of Organic and Bio-organic Supramolecular Chemistry.

Rym Yahia Boudhar

PhD Student

rym.yahiaboudhar@unamur.be

Bibliographical sketch

Rym YAHIA BOUDHAR studied pharmaceutical chemistry at university of Algiers 1. She, then, joined the university of Namur in 2021 where she started a master thesis. She is currently working on the chemical synthesis of clickable sugar-nucleotides analogues for a functionalisation of an antibody.

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Kévin Renault

Researcher

Tel: +32 (0)81 72 54 18
kevin.renault@unamur.be

Bibliographical sketch:

Kévin obtained a Ph. D. thesis in organic chemistry in 2018 from Normandie université in Rouen (France) under the co-direction of Dr. Cyrille Sabot and Prof. Pierre-Yves Renard in COBRA laboratory. This thesis is entitled “Development of chemoselectives ligations “click”- application to the synthesis of fluorogenic probes”.

From 2019 to 2021, he obtained a post-doctoral position at ICMUB laboratory at the Burgundy university, Dijon (France), under the supervision of Prof. Anthony Romieu. He worked on the development of new fluorogenic probes based on covalent assembly principle for enzymes detection. 

Since September 2021, he started a post-doctoral position in the laboratory of Chimie Bio-Organique (CBO) under the supervision of Prof. Stéphane Vincent at the University of Namur. This research project concerns the development of methodology to synthesized fluorinated sugar derivate.

Research activities:

K. Renault, A. Chevalier, J. Bignon, D. Jacquemin*, J.-A. Richard, A. Romieu. Coumarin-Pyronin Hybrid Dyes: Synthesis, Fluorescence Properties and Theoretical Calculations. ChemPhotoChem, 2021, 5, 822-838, DOI: 10.1002/cptc.202100069.

K. Renault, S. Debieu, J.-A. Richard, A. Romieu. Deeper insight into protease-sensitive “covalent-assembly” fluorescent probes for practical biosensing applications. Org. Biomol. Chem. 2019, 17, 8918-8932. DOI: 10.1039/C9OB01773A.  

K. Renault, C. Guillou, P.-Y. Renard, C. Sabot. Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules. Org. Biomol. Chem. 2019, 17, 388-396. DOI: 10.1039/C8OB02108B.

K. Renault, P.-Y. Renard, C. Sabot. Detection of Biothiols with a Fast-Responsive and Water-Soluble Pyrazolone-Based Fluorogenic Probe. Eur. J. Org. Chem. 2018, 2018, 6494-6498. DOI: 10.1002/ejoc.201801157.

K. Renault, P.-Y. Renard, C. Sabot. Photophysical properties of quinoxalin-2(1H)-ones: application in the preparation of an azide-based fluorogenic probe for the detection of hydrogen sulfide. New J. Chem. 2017, 41, 10432–10437.                 DOI: 10.1039/C7NJ01893B.

K. Renault, L.-A. Jouanno, A. Lizzul-Jurse, P.-Y. Renard, C. Sabot. Fluorogenic Behaviour of the Hetero-Diels-Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications. Chem. - Eur. J. 2016, 22, 18522-18531. DOI: 10.1002/chem.201603617.

K. Renault, C. Sabot*, P.-Y. Renard. Fast-Responsive Nitroso-Based Turn-On Probe for Hydrogen Sulfide: Nitroso-Based Turn-On Probe for Hydrogen Sulfide. Eur. J. Org. Chem. 2015, 2015, 7992–7996. DOi: 10.1002/ejoc.201501140.

K. Renault, J.W. Fredy, P.-Y. Renard, C. Sabot. Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies. Bioconjugate Chem. 2018, 29, 2497–2513. DOI: 10.1021/acs.bioconjchem.8b00252

Arnaud beaufays

PhD student

Tel: +32 (0)81 72 41 11
arnaud.beaufays@unamur.be

Bibliographical sketch:

Arnaud BEAUFAYS started chemistry studies at the university of Namur in 2014 and he acquires his Bachelor in 2017. As a Master project, he is currently working on the synthesis of rhodamines derivatives to understand the SERS effect.

andrei diaconu

PhD student

Tel: +32 (0)81 72 54 18
andrei.diaconu@unamur.be

Bibliographical sketch:

Andrei Diaconu received his Master degree in Inorganic chemistry from the ‘’Alexantru Ion Cuza” University (Iasi, Romania) in 2014. He then started to work as a chemist in Quality control laboratory for a pharmacological company in Iasi for one and a half years. During that time he used HPLC, UV, IR, titration and other protocols and technics to analize row materials, final products for their quality and also preparing the quality control documents. In November 2016 he started his PhD Scolarship as a jointsupervision between „Petru Poni” Institute of Macromolecular Chemistry from Iasi, Romania and University of Namur, Belgium. His scholarship aims to develop new materials with antibacterial, atibiofilm and drug delivery properties.

Research activities:
- A. C. Druc, A. I. Borhan, A. Diaconu, A. R. Iordan, G. G. Nedelcu, L. Leontie, M. N. Palamaru. Ceramics International 40 (2014) 13573–13578.