Learning outcomes

This clinical nutrition course, organised into ten themed sessions, gives pharmacy masters students an in-depth understanding of both normal and pathological nutrition. 


On completion of this clinical nutrition course, students will be able to define and apply the fundamental principles of clinical nutrition in the Belgian pharmaceutical context. They will be able to assess patients' nutritional status using the appropriate diagnostic tools (BMI, dietary history, biomarkers, etc.) and recognise the clinical signs of malnutrition. They will be able to identify macro- and micronutrient imbalances and propose personalised solutions to correct them.


Students will be able to distinguish between the different nutritional approaches (preventive, curative, palliative) and calculate the energy, water and nitrogen requirements specific to each patient. They will understand the mechanisms of macro- and micronutrient absorption and be able to distinguish the clinical and biological manifestations of deficiencies or excesses.


Particular attention will also be paid to the interactions between enteral and parenteral nutrition and pharmacopoeia. 


The future pharmacist will be able to advise on and monitor the use of the various forms of artificial nutrition, pharmaconutrients, plants and plant extracts available in the pharmacy, taking into account the INAMI reimbursement criteria. They will be able to adapt their nutritional recommendations to specific populations (geriatrics, paediatrics, pregnancy, chronic pathologies, etc.) and effectively coordinate the relay between the hospital and the pharmacy. 


Finally, they will be able to incorporate the emerging concepts of personalised nutrition, nutrigenetics and the role of the microbiota into their future professional practice.

Goals

The course aims firstly to provide students with a solid foundation of knowledge in clinical nutrition, while developing their practical skills in applying this knowledge to patient care. 


This first objective aims to establish a solid foundation for understanding clinical nutrition as a therapeutic discipline. Students will learn to distinguish clinical nutrition from preventive nutrition, understanding its specific areas of application in the hospital and pharmacy setting. They will acquire in-depth knowledge of recommended nutritional intakes and the composition of a balanced diet, while mastering the calculation of individualised water, energy and nitrogen requirements. Learning about the mechanisms of digestion, absorption and metabolism of macronutrients will provide an essential foundation for understanding nutritional dysfunctions.


Students will also develop practical skills in the use of nutritional assessment tools, including the interpretation of biomarkers (albumin, prealbumin, CRP, etc.) and the application of validated screening scores. 


This theoretical training will be supplemented by an introduction to predictive scores and the principles of personalised medicine, preparing future pharmacists for an individualised approach to nutritional management. 

At the end of this part of the course, future pharmacists will have the scientific and technical tools they need to make an effective contribution to nutritional management, in line with current recommendations. The aim is to train professionals capable of identifying, assessing and quantifying nutritional needs in various clinical situations.


2nd Objective: To develop expertise in therapeutic nutrition and pharmaco-nutrition


The second objective of the course is to prepare students to assume their role as pharmacists throughout the patient's care pathway by integrating the nutritional dimension, while making them aware of the pivotal role played by the pharmacist within the multidisciplinary team. 


This objective will focus on acquiring in-depth expertise in therapeutic nutrition, particularly in complex pathological situations. Students will learn to master the various methods of artificial nutrition, from enteral nutrition (choice of polymeric, oligomeric and specialised formulas) to parenteral nutrition. 


They will develop an understanding of the interactions between nutrition and drugs, including physicochemical incompatibilities and pharmacokinetic changes induced by nutritional status or genetic predisposition.


Learning about improved rehabilitation after surgery (RAAC-ERAS) protocols and prehabilitation concepts will enable students to integrate the nutritional dimension into perioperative care. 


Particular attention will be paid to the nutritional management of chronic pathologies (diabetes, cardiovascular disease, cancer, etc.) and acute pathologies (renal failure, digestive pathologies, etc.), taking into account the specific pathophysiological features of each condition. 


Students will also acquire the skills needed to advise on and monitor the use of oral nutritional supplements, pharmaconutrients, plants and plant extracts, while mastering the INAMI classifications and reimbursement criteria. 


The aim is to train pharmacists who are capable of optimising nutritional management in all clinical situations encountered, whether in hospitals or community pharmacies.

In addition, future pharmacists are encouraged to incorporate the prevention and screening of nutritional disorders into their daily practice, in particular by identifying patients at risk in the pharmacy and taking part in nutritional education campaigns.


3rd Objective: Integrate personalised nutrition and therapeutic innovations into pharmaceutical practice


The third objective prepares students for current and future developments in clinical nutrition, with an emphasis on personalised therapeutic approaches. 


Students will explore the mechanisms of hunger and satiety, including the role of regulatory hormones (leptin, ghrelin, GLP-1), in order to gain a better understanding of metabolic dysregulation. 


They will develop expertise in the nutritional management of specific populations (geriatrics, paediatrics, pregnancy, sportspeople), adapting their recommendations to the particular physiological needs of each group. 


Learning the concepts of nutrigenetics and nutrigenomics will enable future pharmacists to incorporate genetic factors into their nutritional advice, for example concerning the metabolic role of methylated vitamins B9/B12.


Students will also gain an in-depth understanding of the role of the intestinal microbiota and the therapeutic use of pre-, pro- and post-biotics. The course will include the study of plant-based medical devices and plant extracts, as well as the management of the hospital-office interface to optimise continuity of nutritional care. 

Finally, the ethical aspects of nutrition in palliative medicine will be addressed, preparing students for the complex dilemmas at the end of life and respect for patient autonomy.

Content

Course 1 (Eric Deflandre): 

- Description of course objectives

o Defining clinical nutrition and its areas of application

o The pharmacist's role in the care pathway

o The difference between preventive, curative and palliative nutrition

- "Normal" diet: 

o Recommended dietary allowances 

o Composition of a balanced diet

o Water, energy and nitrogen requirements

o Reminder of the basic concepts of digestion, absorption and metabolism of carbohydrates, lipids and proteins

- Introduction to predictive scores (statistical bases) and personalised medicine

- Tools for assessing nutritional status : 

o BMI

o Food history

o Clinical signs of malnutrition

o Methods of assessing nutritional status and screening scores (Nutritional Risk Screening, etc.)

o Biomarkers: albumin, prealbumin, CRP, etc.

o Others: impedancemetry, etc.

Lesson 2 (Anthony Sternotte) : 

- Macronutrients

1.    Fatty acid balance (SFAs/MMIs/TFAs/PMFAs)

2.    Pharmaco-nutrients containing nitrogen (arginine, glutamine, citrulline, HMB, tryptophan, tyrosine, etc.)

- Micronutrients

1.    Vitamins:

§ Absorption mechanisms and factors influencing bioavailability

§ Deficiencies and excesses: clinical and biological manifestations

2.    Trace elements

3.    Antioxidants

o Fortified food and oral nutritional supplements (ONS)

Products available in pharmacies : 

1.    INAMI classifications and reimbursement

2.    Indications

3.    The pharmacist's role: advice, monitoring and drug interactions 

 

Course 3 (Eric Deflandre) : 

- Enteral nutrition: 

o Routes of administration (nasogastric tube, gastrostomy, jejunostomy)

o Choice of formulas: 

§ Polymeric

§ Oligomeric

§ Specialised (diabetes, CKD, etc.)

§ ...

o Complications (mechanical, infectious, digestive, etc.)

o Hospital-home coordination

- Parenteral nutrition: 

o Indications

o When to switch from enteral to parenteral nutrition 

o Mixture compositions

o Prescription calculation 

o Biological and clinical monitoring

o Routes of administration: principle, placement, complications

o Reimbursement criteria

o Complications:

§ Infectious

§ Metabolic

§ Mechanical


Lesson 4 (Eric Deflandre) : 

- Mechanisms of hunger and satiety (including the hormones involved: leptins, ghrelin, GLP-1, etc.)

- Epidemiology: of undernutrition and obesity in Europe:

o In the general population

o In hospitals with its repercussions on : 

§ Survival

§ Length of stay 

- Malabsorption

- Benefits of clinical nutrition or "why feed the sick patient?

- ESPEN Guidelines

- Inappropriate renutrition syndrome

  

Course 5 (Eric Deflandre): 

- Interactions between nutrition and drugs: 

o Physicochemical incompatibilities

o Pharmacokinetic interactions (absorption, nutrition and metabolism)

o Drugs altering nutritional status 

o Special case of drugs administered by tube

- Administration of drugs via a nasogastric tube

- Concept of improved rehabilitation after surgery (RAAC-ERAS)

- Concept of prehabilitation 

- Concept of hospitalisation at home (HAD) and artificial nutrition at home (NAD)

- Nutrition in intensive care units

 

Course 6 (Eric Deflandre): 

- Nutrition in specific populations: 

o Geriatrics

o Paediatrics 

o Pregnancy

o Sportspeople and food supplements

o Surgical patients


Course 7 (Eric Deflandre): 

- Nutrition and chronic pathology: 

o Diabetes (type 2), including glycaemic index

o Cardiovascular disease 

o Cancers and severe cachexia

o Obesity and overweight (including surgical treatments and new pharmacological treatments)

o Endometriosis

o Polycystic ovary syndrome

o ...

 

Course 8 (Eric Deflandre) : 

- Nutrition and chronic renal failure

- Nutrition and neurological patients

- Nutrition and abdominal pathologies: 

o digestive (IBD, RCUH, irritable bowel syndrome, etc.), including FODMAP

o hepatic (encephalopathies, high-protein diet, etc.)

o pancreatic insufficiency

- Nutrition for polymorbid patients in hospital

- The ethical dilemma of nutrition in palliative medicine 

 

Course 9 (Anthony Sternotte) : 

- The link between hospitals and community pharmacies (prescriptions, equipment, follow-up, etc.)

- Personalised nutrition

- Nutrigenetics and nutrigenomics (including methylated B9/B12, 2'-fucosyllactose, hereditary cholestasis)

- Epigenetics and nutrition (including conception, pregnancy and the health of offspring)

- Microbiota (Pre-biotic, Pro-biotic, Post-biotic)

- Plants, plant extracts and plant-based medical devices

 

Lesson 10 (Eric Deflandre) : 

- Cross-sectional view

- Q&A

- Practical aspects

Table of contents

- Description of course objectives

o Definition of clinical nutrition and its areas of application

o Role of the pharmacist in the care pathway

o Difference between preventive, curative and palliative nutrition

- Description of a "normal" diet.

o Recommended nutritional intake 

o Composition of a balanced diet

o Water, energy and nitrogen requirements

o Reminder of the basic concepts of digestion, absorption and metabolism of carbohydrates, lipids and proteins

- Physiology and Physiopathology: 

o Mechanisms of hunger and satiety (including the hormones involved : leptins, ghrelin, GLP-1, etc.)

o Epidemiology: undernutrition and obesity in Europe 

o Introduction to predictive scores (statistical bases) and personalised medicine

o Tools for assessing a patient's nutritional status, including clinical aspects.

o Benefits of clinical nutrition or "why feed the sick patient?"

o EPSEN Guidelines

The different forms of clinical nutrition: 

o Macronutrients and micronutrients

o Enriched food and oral nutritional supplements (ONS)

o Enteral nutrition 

o Parenteral nutrition

o Nutrition in intensive care

o Administration of drugs via a nasogastric tube

- The place of clinical nutrition in hospital practice: 

o Interactions between nutrition and medication 

o Concept of improved rehabilitation after surgery (RAAC-ERAS)

o Concept of prehabilitation 

o Concept of hospitalisation at home (HAD) and artificial nutrition at home (NAD)

- Nutrition in specific populations: 

o Geriatrics

o Paediatrics 

o Pregnancy 

o Sportspeople and nutritional supplements

o Surgical patients

o ...

Nutrition and chronic pathologies: 

o Diabetes 

o Cardiovascular diseases 

o Cancers and severe cachexia

o Obesity and overweight 

o Endometriosis

o Polycystic ovary syndrome

o ...

- Nutrition and acute and digestive pathologies :

o Chronic renal failure

o Neurological diseases

o Patients with polymorbidities

o Digestive, hepatic and pancreatic diseases

- The ethical dilemma of clinical nutrition in palliative medicine

- The link between hospital and community pharmacies (prescriptions, equipment, follow-up, etc.) - Personalised nutrition - Nutrigenutrition - Nutrition for the elderly )

- Personalised nutrition

- Nutrigenetics and nutrigenomics 

- Epigenetics and nutrition 

- Microbiota (Pre-biotic, Pro-biotic, Post-biotic)

- Plants, plant extracts and plant-based medical devices

Teaching methods

The 20-hour course will be taught ex cathedra. 16 of the 20 hours will be taught by Mr Eric Deflandre (Anaesthetist-Resuscitator) and the remaining four hours by Mr Anthony Sternotte (Pharmacist). The training will be essentially practical in order to help future pharmacists in the vast and complex field of nutrition.

Assessment method

The questions will be distributed fairly according to the hours of lectures given: 

- Questions relating to Mr Deflandre's lectures will account for 80% of the questions on the exam and may consist of MCQs, open questions and practical clinical case studies. 

- Questions relating to Mr Anthony Sternotte's courses will account for 20% of the exam questions and may consist of MCQs, open questions and solving practical clinical cases.

Language of instruction

French