Goals

The course “Eukaryotic Microorganisms” explores the molecular and evolutionary principles underlying gene expression and diversity in eukaryotes microbes. Students will examine the differences between prokaryotic and eukaryotic gene expression, including mechanisms of transcription elongation, termination, stress responses, and sexual differentiation. The course also addresses major evolutionary processes such as eukaryogenesis, genetic diversity, speciation, gene gain/loss, and horizontal gene transfer, while considering the features of early eukaryotic ancestors (LECA/FECA). Through discussions and case studies, students are expected to demonstrate a solid understanding of these concepts, apply their knowledge to novel biological problems, and critically explore new ideas. Special emphasis is placed on integrating perspectives of evolution, ecology, and applications to appreciate the role of eukaryotic microorganisms in both natural systems and research or industrial contexts.

Content

• Microorganisms to study eukaryotoc gene expression:

  • eukaryote vs prokaryote in gene expression
  • transcription elongation
  • transcription termination mechanisms
  • Stress response & sexual differentiation


• Evolution of eukaryotic microorganisms:

  • eukaryogenesis
  • generation of genetic diversity
  • speciation, gene gain/loss, horizontal gene transfer
  • features of LECA/FECA


• Features of selected eukaryotic microorganisms:

Species selection changes every year but might include

  • yeast
  • amoeba
  • diatoms

Teaching methods

Ex-cathedra classes ponctuated with interventions from external experts

Supervised learning (group project) and reversed teaching.

Assessment method

50% of the final grade:

  • Group project and presentation in front of the class.
  • Participation will also be graded


50% of the final grade:

  • oral exam


Language of instruction

English
Training Study programme Block Credits Mandatory
Master in Molecular Microbiology, Research focus Standard 0 2
Master in Molecular Microbiology, Research focus Standard 1 2