Learning outcomes

- In-depth knowledge of cell biology under normal and pathological conditions.

- Presentation, Interpretation and Critical Analysis of results published in the scientific literature.

Goals


The main objectives of this course are: 1) to learn about the cellular mechanisms responsible for the development of several diseases based on experimental results published in the scientific literature and 2) to learn to present scientific results in an appropriate language and structure.


At the end of the lesson, the student should be able to :


- explain the purpose of the experiments.


- explain the techniques used.


- describe and analyse the results of the experiments.


- to integrate these results into a broader context taking into account theoretical knowledge.


- to understand the cellular mechanisms responsible for the pathogenesis of several diseases.

Content


After a general description of pathologies, we will discuss intracellular mechanisms that are affected. We will therefore look at the ubiquitin-proteasome system, aggregation, macroautophagy, chaperone-mediated autophagy, lysosomal exocytosis, as well as intraneuronal transport of lysosomes and autophagosomes. To this end, we will draw on experimental results and models published in the literature.

The pathologies will be grouped into two categories:

1. Diseases related to protein misfolding (Mucoviscidosis-Serpinopathy-Parkinson's Disease-Alzheimer's Disease)

2. Diseases related to vesicular transport defects (COPA syndrome, Familial haemophagocytic lymphohistiocytosis-Lysosomal storage diseases-Lowe syndrome).

Table of contents

1. Diseases related to a protein misfolding

Mucoviscidosis

Serpinopathy

Parkinson's Disease

Alzheimer's Disease

2. Diseases related to a vesicular transport defect

COPA syndrome

Familial haemophagocytic lymphohistiocytosis

Lysosomal storage diseases

Lowe syndrome

Exercices

Wooclap

Tests on WebCampus

Co-requisites

[MBIMB311]

Teaching methods


Slide presentation and Wooclap tests

Assessment method

Oral examination with preparation.

Sources, references and any support material

Slides with bibliographic references, course notes

Language of instruction

French