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Abstract Primarily described as an alarmone, secondary messenger (p)ppGpp, when accumulated, binds to many targets involved in DNA replication, translation, and transcription. In the asymmetrically-dividing a-proteobacterium Caulobacter crescentus, (p)ppGpp has been shown to strongly impact cell cycle progression and differentiation, promoting the non-replicating G1/swarmer phase. Mutations in the major subunits of transcriptional complex, b or b' subunits, were able to display the (p)ppGpp-related phenotypes even in the absence of the alarmone. We identified that the transcriptional holo-enzyme, RNA polymerase (RNAP) is a primary target of (p)ppGpp in C. crescentus. Furthermore, mutations that inactivate (p)ppGpp binding to RNAP annihilated the (p)ppGpp-related phenotypes and phenocopied a (p)ppGpp0 strain. Our RNAseq analysis further elucidated the changes in the transcriptional landscape of C. crescentus cells displaying different (p)ppGpp levels and expressing RNAP mutants. Since the DNA replication initiation protein DnaA is required to exit the G1 phase, we observed that it was significantly less abundant in cells accumulating (p)ppGpp. We further explored its proteolysis under the influence of (p)ppGpp. Our work suggests that (p)ppGpp regulates cell cycle and differentiation in C. crescentus by reprogramming transcription and triggering proteolytic degradation of key cell cycle regulators by yet unknown mechanisms. In Part II, we identified two σ factors belonging to the ECF family that might be involved in this (p)ppGpp-accompanied phenotypes. In Part III, we propose an overlapping role of the ω subunit, RpoZ, and the heat shock subunit, RpoH, in carbon metabolism.JuryProf. Gipsi LIMA MENDEZ (UNamur), PresidentProf Régis HALLEZ (UNamur), SecretaryDr Emanuele BIONDI (CNRS-Université Paris-Saclay)Prof. Justine COLLIER (University of Lausanne)Dr Marie DELABY (Université de Montréal)

Abstract Estrogens originating from human and animal excretion, as well as from anthropogenic sources such as cosmetics, plastics, pesticides, detergents, and pharmaceuticals, are among the most concerning endocrine-disrupting compounds in aquatic environments due to their potent estrogenic activity. While their effects on fish reproduction are well documented, their impact on development, particularly metamorphosis, remains poorly studied. This hormonal transition, mainly controlled by the thyroid axis, is essential for the shift from the larval to the juvenile stage in teleosts.The effects of two contraceptive estrogens on zebrafish (Danio rerio) metamorphosis were evaluated: 17α-ethinylestradiol (EE2), a synthetic reference estrogen, and estetrol (E4), a natural estrogen recently introduced in a new combined oral contraceptive formulation. Continuous exposure from fertilization to the end of metamorphosis allowed the assessment of morphological changes, disruptions of the thyroid axis, and modifications of additional molecular pathways potentially involved in metamorphic regulation.EE2 induced significant delays and disturbances in metamorphosis, affecting both internal and external morphological traits, confirming its role as an endocrine disruptor of concern. In contrast, E4 did not cause any detectable morphological alterations even at concentrations far exceeding those expected in the environment, indicating a limited ecotoxicological risk. Molecular analyses showed that EE2 strongly affected thyroid signaling and energy metabolism during metamorphosis, whereas E4 induced only minor transcriptional and proteomic changes.This study provides the first evidence that EE2 can disrupt zebrafish metamorphosis and highlights the importance of including this developmental stage in ecotoxicological assessments. The results also suggest a larger environmental safety margin for E4, although further research is needed to clarify the mechanisms linking estrogen exposure to metamorphic regulation.JuryProf. Frederik DE LAENDER (UNamur), PresidentProf. Patrick KESTEMONT (UNamur), SecretaryDr. Sébastien BAEKELANDT (UNamur)Dr. Valérie CORNET (UNamur)Prof. Jean-Baptiste FINI (Muséum National d'Histoire Naturelle, Paris)Dr. Marc MULLER (ULiège)Prof. Veerle DARRAS (KULeuven)

A flurry of awards for the NaDI-CeRCLe research center in recent weeks. The service management research of three young doctoral students from the EMCP Faculty has been recognized by their peers at leading international scientific events: Floriane Goosse, Victor Sluÿters and Florence Nizette. This summer, we invite you to discover their careers and their work.

The team of professor Xavier De Bolle has just published an article in the prestigious EMBO Journal published by Springer Nature.  His discovery? A lipid transport channel through the cell membrane of Brucella, the bacteria responsible for Brucellosis in cattle. This finding could be used to generate attenuated strains of the bacteria; a process used in vaccine manufacturing. 

New from 2025-2026 The MAGIS program is a unique and exclusive exchange program that will transform you into a global citizen, a global agent of change.

Global environmental citizenship Course The Global environmental citizenship course is an international course on global citizenship, focusing on environmental justice. It is taught online and coordinated by a professor from Loyola University Chicago. The course objectives are: Understand the local and global impacts of biodiversity loss, water scarcity and climate changeEvaluate these impacts from a moral and spiritual perspectiveAct as responsible citizens, locally and globally, in the face of these challengesStudents selected for the MAGIS program will take the first part of the course during the 2nd quadrennium of Block 2 and the second part during the first quadrennium of Block 3. Discover the projects created by our students Course" exchange stay The "course" exchange stay enables students selected for the MAGIS program to take courses (for +/- 30 ECTS credits) during one term (the 1st term of Boc 3) at one of the participating Jesuit universities in or outside Europe.The stay is supported by a "course" mobility grant for partner universities where a bilateral agreement has been concluded with UNamur. This information can be found in the list of MAGIS program partners on Webcampus. Scholarship information Service Learning During the exchange stay, the students selected for the MAGIS program will carry out a service learning mission (internship, volunteering, etc), organized and supervised by the host University. This will enable students to:Understand the local environmentGet involved in community supportLearn and take on responsibilities Organization of these 3 components These three components are organized as follows:

Japan is almost 10,000 kilometers from Belgium, a country that fascinates, not least for its rich culture full of contrasts. Researchers at UNamur maintain close ties with several Japanese institutions, particularly in the fields of computer science, mathematics and video games. Let's take a look at some of these collaborations..

An international team of researchers has just published an article in the prestigious journal Light: Science & Applications (LSA) from the Nature group.  The teams led by Professors Michaël Lobet and Alexandre Mayer (University of Namur) collaborated with the team led by Professor Shanhui Fan, one of the leading experts in the field, from the prestigious Stanford University in California (USA).  The result: an article entitled ‘Twist-Induced Beam Steering and Blazing Effects in Photonic Crystal Devices’, or the study of beam deflection by twisting in photonic crystal devices.  Come on, let's twist light again at UNamur! 

Abstract This work demonstrates that polymer-coated gold nanoparticles can function not only as radiosensitizers but also as agents for macrophage reprogramming. Specifically, we show that these nanoparticles can repolarize tumor-associated macrophages from the immunosuppressive M2 phenotype to the pro-inflammatory M1 phenotype-a process further enhanced by clinically relevant doses of X-ray radiation. Among the four nanoparticle formulations tested, 50 nm PVP-coated gold nanoparticles were particularly effective in promoting macrophage repolarization and reducing pancreatic cancer cell viability in co-culture, both with and without radiation. These findings highlight a promising strategy to enhance the efficacy of cancer radiotherapy. Jury Prof. Julien COLAUX (UNamur), ChairmanProf. Anne-Catherine HEUSKIN (UNamur), SecretaryProf. Carine MICHIELS (UNamur)Prof. Henri-François RENARD (UNamur)Prof. Michel MOUTSCHEN (ULiège)Dr Dimitri STANICKI (UMons)Prof. Devika CHITHRANI (University of Victoria)

Semantic change, i.e. the evolution of word meanings over time, offers crucial information about historical, cultural and linguistic processes. Language acts as a mirror of societal change, reflecting evolving values, norms and technological advances. Understanding how the meaning of words evolves enables us to trace these transformations and gain a deeper understanding of our distant and recent past.This seminar explores how computational methods are revolutionizing our ability to analyze semantic change in historical texts, addressing a major challenge in the field of digital humanities. While advanced computational methods enable us to analyze vast datasets and uncover previously inaccessible patterns, few natural language processing algorithms fully take into account the dynamic nature of language, particularly semantics, which is essential for research in the humanities. As AI systems develop to better understand the historical context and dynamics of language, human annotation and interpretation remain essential to capture the nuances of language and its cultural context.In this presentation, I will show how computational and human-centered approaches can be effectively combined to examine semantic change and its links to cultural and technological developments. I will present examples illustrating how semantic change can be analyzed across temporal, cultural and textual dimensions."Methods "seminarsThe Methods Seminar is a series of seminars organized at the University of Namur with the aim of fostering interdisciplinary collaboration and knowledge exchange. All seminars take place in a hybrid format.This seminar series focuses on advanced methodological approaches, particularly in the fields of natural language processing (NLP), artificial intelligence (AI), video and image analysis, and multimodal analysis.To stay informed about details of upcoming seminars, please subscribe to our mailing list below. I subscribe to the "Methods" mailing list

More info to come."Methods "seminarsThe Methods Seminar is a series of seminars organized at the University of Namur with the aim of fostering interdisciplinary collaboration and knowledge exchange. All seminars take place in a hybrid format.This seminar series focuses on advanced methodological approaches, particularly in the fields of natural language processing (NLP), artificial intelligence (AI), video and image analysis, and multimodal analysis.To stay informed about details of upcoming seminars, please subscribe to our mailing list below. I subscribe to the "Methods" mailing list