Les membres de l'équipe sont spécialisés dans les techniques de microscopie optique pour l’étude du trafic protéique, notamment la microscopie confocale et la microscopie des cellules vivantes, incluant la microscopie à feuille de lumière en réseau. 

L’équipe travaille dans un environnement hautement collaboratif et interdisciplinaire, combinant biologie cellulaire, biologie chimique, microscopie avancée et analyses d’images afin d’élaborer des projets allant de la biologie fondamentale à la recherche translationnelle. 

Nos publications

H Farhan, I Raote, F Campelo, L Ge, K Hirschberg, A Forrester, G Zanetti, J Lippincott-Schwartz, JC Pastor-Pareja, F Perez, K Saito, V Malhotra.Towards a unified framework for the function of endoplasmic reticulum exit sites.
All authors contributed equally to this work. Nature Reviews Molecular Cell Biology 2025 https://doi.org/10.1038/s41580-025-00899-0

E Macdonald, A Forrester, CA Valades-Cruz, TD Madsen, JHR Hetmanski, E Dransart, Y Ng, R Godbole, A Akhil, L Leconte, V Chambon, D Ghosh, A Pinet, D Bhatia, B Lombard, D Loew, MR Larson, H Leffler, DJ Lefeber, H Clausen, P Caswell, M Shafaq-Zadah, S Mayor, R Weigert§, C Wunder§, L Johannes§. Growth factor-induced desialylation for the fast control of endocytosis.
Nature Cell Biology 2025 https://doi.org/10.1038/s41556-025-01616-x

N He, L Depta, C Rossetti, L Caramelle, M Cigler, HP Bryce-Rogers, M Michon, O Rafn Dan, J Hoock, J Barber, D Gillet, A Forrester, GE Winter, L Laraia§. Selective inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation. 
Nature Chemical Biology 2024 https://doi.org/10.1038/s41589-024-01653-x

M Cigler, H Imrichova, F Frommelt, L Caramelle, L Depta, A Rukavina, C Kagiou, JT Hannich, C Mayor-Ruiz, G Superti-Furga, S Sievers, A Forrester, L Laraia, H Waldmann§, GE Winter§. Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP.
Nature Chemical Biology 2024 https://doi.org/10.1038/s41589-024-01614-4

CM. Robinson, A Duggan, A Forrester§. ER exit in physiology and disease.
Frontiers in Molecular Biosciences 2024 https://doi.org/10.3389/fmolb.2024.1352970

Y Wu, C Taisne, N Mahtal, A Forrester, M Lussignol, JC Cintrat, A Esclatine, D Gilet§, J Barbier§. Autophagic degradation is involved in cell protection against Ricin toxin.
Toxins 2023 https://doi.org/10.3390/toxins15050304

A Forrester*, SJ Rathjen*, MD Garcia-Castillo*, Collin Bachert, Audrey Couhert, Livia Tepshi, Sylvain Pichard, Jennifer Martinez, Mathilde Munier, Raphael Sierocki, Henri-François Renard, César Augusto Valades-Cruz, Florent Dingli, Damarys Loew, Christophe Lamaze, Jean-Christophe Cintrat, Adam D. Linstedt, Daniel Gillet§, Julien Barbier, Ludger Johannes§. Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2.       
Nature Chemical Biology 2020 https://doi.org/10.1038/s41589-020-0474-4

# A Forrester*, C De Leonibus*, P Grumati*, E Fasana*, M Piemontese, L Staiano, I Fregno, A Raimondi, A Marazza, G Bruno, M Iavazzo, D Intartaglia, M Seczynska, E van Anken, I Conte, MA De Matteis, I Dikic§, M Molinari§, C Settembre§. A selective ER-phagy exerts procollagen quality control via a CALNEXIN-FAM134B complex.                                        
EMBO J. 2019 https://doi.org/10.15252/embj.201899847

R Bartolomeo, L Cinque, C De Leonibus, A Forrester, AC Salzano, J Monfregola, E De Gennaro, E Nusco, I Azario, C Lanzara, M Serafini, B Levine, A Ballabio, C Settembre. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.                                       
The Journal of Clinical Investigation. 2017 https://doi.org/10.1172/JCI94130

L Cinque, A Forrester, C Settembre. Autophagy gets to the bone. 
Cell Cycle, 2016 https://doi.org/10.1080/15384101.2016.1151724

L Cinque*, A Forrester*, R Bartolomeo, M Svelto, R Venditti, S Montefusco, E Polishchuk, E Nusco, A Rossi, DL Medina, R Polishchuk, MA De Matteis & C Settembre. FGF signalling regulates bone growth through autophagy. 
Nature. 2015 https://doi.org/10.1038/nature16063

D Medina, S Di Paola, I Peluso, A Armani, D De Stefani, R Venditti, S Montefusco, A Scotto-Rosato, C Prezioso, A Forrester, C Settembre, W Wang, Q Gao, H Xu, M Sandri, R Rizzuto, A De Matteis & A Ballabio (2015) Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. 
Nature Cell Biology.2015 https://doi.org/10.1038/ncb3114

AR Forrester, MS Elias, EL Woodward, M Graham, FM Williams & NJ Reynolds. Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down.
Journal of Dermatological Science.2014 https://doi.org/10.1016/j.jdermsci.2013.09.001

MC Leach, AR Forrester & PA Flecknell. Influence of preferred foodstuffs on the antinociceptive effects of orally administered buprenorphine in laboratory rats.
Laboratory Animals. 2010 https://doi.org/10.1258/la.2009.009029