Chaire Francqui 2021-2022 - Faculté de Médecine
Sophie LUCAS acquired an M.D. degree in 1994 at the University of Louvain in Belgium, and a Ph.D. degree in 2000 for her work in the field of tumor immunology under the mentorship of Pr Thierry Boon. She identified and characterized novel genes encoding human tumor-specific antigens, some of which were used in clinical trials of therapeutic vaccination against cancer.
Her early post-doctoral work was devoted to studying new cytokines and cytokine receptors in the laboratory of F. de Sauvage at Genentech, a bio-technological company located in San Francisco (USA). In 2004, she founded her own research group at the de Duve Institute, located on the medical campus of the UCLouvain in Brussels. She became Research Associate with the FNRS in 2008, then Professor in Cancer Immunotherapy at UCLouvain in 2016. The long-term objective of her research is to identify molecular mechanisms by which regulatory T cells (Tregs) inhibit anti-tumor T cell responses, with a particular emphasis on the production of active TGF-b1, a cytokine with potent immune suppressive functions. Her group recently identified a protein named GARP, which presents and activates the latent form of TGF-b1 on the surface of Tregs. They derived monoclonal antibodies against GARP that block TGF-b1 activation and immunosuppression by human Tregs and are currently investigating the possibility to use these monoclonals as a novel approach for the immunotherapy of cancer.
programme
Leçon inaugurale : Vers l'immunothérapie dans un monde selon GARP
Date: Jeudi 10 février 2022
Heure: 17h30
Lieu: Auditoire S01 (Faculté des Sciences)
La leçon inaugurale s'adresse à tout public.
Leçon 2 : Une brève histoire des immunothérapies du cancer: des antigènes tumoraux aux " inhibiteurs de checkpoint ".
Date: Jeudi 17 février 2022
Heure: 17h30
Lieu: Auditoire S01
Leçon 3 : Immunité anti-tumorale, immunosuppression et immunothérapie du cancer: le monde des Tregs selon GARP - Part I.
Date: Jeudi 24 février 2022
Heure: 17h30
Lieu: Auditoire S01
Leçon 4 : IMMUNITÉ ANTI-TUMORALE, IMMUNOSUPPRESSION ET IMMUNOTHÉRAPIE DU CANCER: LE MONDE DES TREGS SELON GARP - PART II.
Date: Jeudi 3 mars 2022
Heure: 17h30
Lieu: Auditoire S01
Leçon 5 : Des immunothérapies pour cibler les Tregs dans les maladies allo-immunitaires, auto-immunitaires et fibrotiques
Date: jeudi 10 mars 2022
Heure: 17h30
Lieu: Auditoire S01
En pratique
Accréditation demandée.
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