Axes de recherches

Les principaux axes de recherche du LCT concernent:

3 main research axes are developed:

Topic A – Tuberculosis 1

Novel strategies to fight tuberculosis: inhibition and mechanistic study of the galactofuranose biosynthesis

Topic a

1.  a) K.E. van Straaten,  C.M. Sevrain, S.A. Villaume, J. Jiménez-Barbero, B. Linclau, S.P. Vincent, D.A.R. Sanders J. Am. Chem. Soc. 2015, 37, 1230-44

     b) S. El Bkassiny, I. N’Go, C.M. Sevrain, A. Tikad, S.P. Vincent Org. Lett. 2014, 16, 2462−65

     c) I. N’Go, S. Golten, Ana Ardá, J. Cañada, J. Jiménez-Barbero, B. Linclau,  S.P. Vincent Chem. Eur. J. 2014, 20, 106-12

     d) C. Ansiaux, I. N’Go, S.P. Vincent    Chem. Eur. J. 2012, 18, 14860-66.

 

Topic B - Glycofullerenes

Glycofullerenes as bacterial antiadhesive molecules2 and glycosyltransferase inhibitors3

 

Topic B 1Topic B 2Topic B 3

A giant fullerene system inhibits the infection by an artificial Ebola virus
(Picture realized by JF Nierengarten)

Fullerene sugar balls

 

2. a) K. Buffet, E. Gillon, M. Holler, J.-F. Nierengarten, A. Imberty, S.P. Vincent  Org. Biomol. Chem. 2015, 13, 6482-92
    b) M. Durka, K. Buffet, J. Iehl, M Holler, J.-F. Nierengarten, J. Taganna, J. Bouckaert, S.P. Vincent Chem. Commun. 2011, 47, 1321-3 
    c) J.-F. Nierengarten, J. Iehl, V. Oerthel, M Holler, B.M. Illescas, A. Muñoz, N. Martín, J. Rojo, M. Sánchez-Navarro, S. Cecioni, S. Vidal, K. Buffet, M. Durka,
        S.P. Vincent Chem. Commun. 2010, 46, 3860-62.

3. M. Durka, K. Buffet, J. Iehl, M Holler, J.-F. Nierengarten, S.P. Vincent Chem. Eur. J. 2012, 18, 641-651.

 

 

Topic C - Antivirulence

Synthesis of inhibitors of the LPS (lypoPolySaccharide) biosynthetic pathway: towards antivirulence molecules4.

 

Topic C

1. a) M. Durka, A. Tikad,  R. Périon,  M. Bosco, M. Andaloussi, S. Floquet,  E. Malacain, F. Moreau, M. Oxoby, V. Gerusz, S.P. Vincent Chem. Eur. J. 2011, 17,
        11305-13;
    b) H. Dohi, R. Périon, M. Durka, M. Bosco, Y. Roué, F. Moreau, S. Grizot, A. Ducruix, S. Escaich, S. P. Vincent  Chem. Eur. J. 2008, 14, 9530-39
    c) S. Grizot, M. Salem, V. Vongsouthi, L. Durand; F. Moreau; H. Dohi, S. Vincent, S. Escaich, A. Ducruix J. Mol. Biol. 2006, 363, 383-94.

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