Laboratoire de Chimie Bio-Organique (CBO)

The laboratory of Prof. Vincent is specialized in bio-organic chemistry, with a special emphasis in glycosciences. In particular, the laboratory is interested in the mechanistic and inhibition studies of essential enzymes involved in the bacterial cell wall biosynthesis and the colonization processes by important human pathogens. The laboratory belongs to the “Unité de Chimie Organique” (Chemistry Department, UNamur). Since the creation of the laboratory, 9 PhD and 17 Master students have completed their thesis and 15 post-doctoral fellows have spent at least one year in the laboratory.

Présentation

The laboratory of Prof. Vincent is specialized in bio-organic chemistry, with a special emphasis in glycosciences.

In particular, the laboratory is interested in the mechanistic and inhibition studies of essential enzymes involved in the bacterial cell wall biosynthesis and the colonization processes by important human pathogens.  

The laboratory belongs to the “Unité de Chimie Organique” (Chemistry Department, UNamur).

Since the creation of the laboratory, 9 PhD and 17 Master students have completed their thesis and 15 post-doctoral fellows have spent at least one year in the laboratory.

Axes de recherches

Les principaux axes de recherche du LCT concernent:

3 main research axes are developed:

Topic A – Tuberculosis 1

Novel strategies to fight tuberculosis: inhibition and mechanistic study of the galactofuranose biosynthesis

Topic a

1.  a) K.E. van Straaten,  C.M. Sevrain, S.A. Villaume, J. Jiménez-Barbero, B. Linclau, S.P. Vincent, D.A.R. Sanders J. Am. Chem. Soc. 2015, 37, 1230-44

     b) S. El Bkassiny, I. N’Go, C.M. Sevrain, A. Tikad, S.P. Vincent Org. Lett. 2014, 16, 2462−65

     c) I. N’Go, S. Golten, Ana Ardá, J. Cañada, J. Jiménez-Barbero, B. Linclau,  S.P. Vincent Chem. Eur. J. 2014, 20, 106-12

     d) C. Ansiaux, I. N’Go, S.P. Vincent    Chem. Eur. J. 2012, 18, 14860-66.

 

Topic B - Glycofullerenes

Glycofullerenes as bacterial antiadhesive molecules2 and glycosyltransferase inhibitors3

 

Topic B 1Topic B 2Topic B 3

A giant fullerene system inhibits the infection by an artificial Ebola virus
(Picture realized by JF Nierengarten)

Fullerene sugar balls

 

2. a) K. Buffet, E. Gillon, M. Holler, J.-F. Nierengarten, A. Imberty, S.P. Vincent  Org. Biomol. Chem. 2015, 13, 6482-92
    b) M. Durka, K. Buffet, J. Iehl, M Holler, J.-F. Nierengarten, J. Taganna, J. Bouckaert, S.P. Vincent Chem. Commun. 2011, 47, 1321-3 
    c) J.-F. Nierengarten, J. Iehl, V. Oerthel, M Holler, B.M. Illescas, A. Muñoz, N. Martín, J. Rojo, M. Sánchez-Navarro, S. Cecioni, S. Vidal, K. Buffet, M. Durka,
        S.P. Vincent Chem. Commun. 2010, 46, 3860-62.

3. M. Durka, K. Buffet, J. Iehl, M Holler, J.-F. Nierengarten, S.P. Vincent Chem. Eur. J. 2012, 18, 641-651.

 

 

Topic C - Antivirulence

Synthesis of inhibitors of the LPS (lypoPolySaccharide) biosynthetic pathway: towards antivirulence molecules4.

 

Topic C

1. a) M. Durka, A. Tikad,  R. Périon,  M. Bosco, M. Andaloussi, S. Floquet,  E. Malacain, F. Moreau, M. Oxoby, V. Gerusz, S.P. Vincent Chem. Eur. J. 2011, 17,
        11305-13;
    b) H. Dohi, R. Périon, M. Durka, M. Bosco, Y. Roué, F. Moreau, S. Grizot, A. Ducruix, S. Escaich, S. P. Vincent  Chem. Eur. J. 2008, 14, 9530-39
    c) S. Grizot, M. Salem, V. Vongsouthi, L. Durand; F. Moreau; H. Dohi, S. Vincent, S. Escaich, A. Ducruix J. Mol. Biol. 2006, 363, 383-94.

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