Publications

Trypanosoma infection favors Brucella elimination via IL-12/IFNγ-dependent pathways - Machelart, A., Van Vyve, M., Potemberg, G., Demars, A., De Trez, C., Tima, H. G., Vanwalleghem, G., Romano, M., Truyens, C., Letesson, J. J. & Muraille, E. 31 Jul 2017 In : Frontiers in Immunology. 8, JUL, 903

Research output: Research - peer-reviewArticle

CtrA Controls Cell Division and Outer Membrane Composition of the Pathogen Brucella abortus - Francis, N., Poncin, K., Fioravanti, A., Vassen, V., Willemart, K., Ong, T. A. P., Rappez, L., Letesson, J-J., Biondi, E. G. & De Bolle, X. 2017 In : Molecular microbiology. 103, 5, p. 780-797 17 p.

Research output: Research - peer-reviewArticle

Identification of Immune Effectors Essential to the Control of Primary and Secondary Intranasal Infection with Brucella melitensis in Mice - Hanot Mambres, D., Machelart, A., Potemberg, G., De Trez, C., Ryffel, B., Letesson, J-J. & Muraille, E. 2016 In : Journal of Immunology. 196, 9, p. 3780-93 14 p.

Research output: Research - peer-reviewArticle

Mitochondria : A target for bacteria - Lobet, E., Letesson, J-J. & Arnould, T. 1 Apr 2015 In : Biochemical Pharmacology. 94, 3, p. 173-185 13 p.

Research output: Research - peer-reviewArticle

In Situ Characterization of Splenic Brucella melitensis Reservoir Cells during the Chronic Phase of Infection in Susceptible Mice - Hanot Mambres, D., Machelart, A., Vanderwinden, J-M., De Trez, C., Ryffel, B., Letesson, J-J. & Muraille, E. 2015 In : PloS one. 10, 9, p. e0137835

Research output: Research - peer-reviewArticle

L’évolution, de l’univers aux sociétés. Objets et concepts - Guillaume Lecointre, Giuseppe Longo , Alain Pavé, Bernard Walliser, Pierre Deleporte, Valérie Masson-Delmotte, Hervé Zwirn, Denis Couvet, Hugues Bersini, Jean-Pierre Bibring , Jonathan Braine, Sébastien Charnoz , Patrick De Wever, Emmanuel Douzery, Sylvia Ekström, Muriel Gargaud, Matthieu Gounelle, Thierry Jacq , Emmanuelle Javaux, Etienne Klein , Marc Lachièze-Rey, Jean-Jacques Letesson, Louis Le Sergeant d’Hendecourt , Hervé Martin, Éric Muraille, Daniele Pinti , Nicolas Prantzos, René Rezsohazy, Carole Smadja , Jean Vandenhaute, Brigitte Zanda, Lecointre, G. (ed.) & Gargaud, M. (ed.) 2015 Éditions Matériologiques. 504 p. (Collection "Sciences & philosophie")

Research output: ResearchBook

On n’est jamais seul dans la vie. Essai sur l’inextricabilité de l’individu biologique - Rézsohazy, R., Letesson, J-J. & Muraille, É. 2015 L’évolution, de l’univers aux sociétés. Objets et concepts. Éditions Matériologiques, p. 377-394 18 p.

Research output: ResearchChapter

Par le petit bout de la lorgnette. Individus et évolution : contributions bactériennes et virales - Letesson, J-J., Muraille, É. & Rézsohazy, R. 2015 L’évolution, de l’univers aux sociétés. Objets et concepts. Éditions Matériologiques, p. 395-420 26 p.

Research output: ResearchChapter

Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella - Barbier, T., Collard, F., Zúñiga-Ripa, A., Moriyón, I., Godard, T., Becker, J., Wittmann, C., Van Schaftingen, E. & Letesson, J-J. 16 Dec 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 50, p. 17815-17820 6 p.

Research output: Research - peer-reviewArticle

Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy - Hamer, I., Goffin, E., De Bolle, X., Letesson, J-J. & Jadot, M. 2 Sep 2014 In : BMC microbiology. 14, 1, 14

Research output: Research - peer-reviewArticle

The quest for a true One Health perspective of brucellosis - Godfroid, J., De bolle, X., Roop, R. M., O'Callaghan, D., Tsolis, R. M., Baldwin, C., Santos, R. L., McGiven, J., Olsen, S., Nymo, I. H., Larsen, A., Al Dahouk, S. & Letesson, J. J. Aug 2014 In : OIE Revue Scientifique et Technique. 33, 2, p. 521-538 18 p.

Research output: Research - peer-reviewArticle

Humoral Immunity and CD4+ Th1 Cells Are Both Necessary for a Fully Protective Immune Response upon Secondary Infection with Brucella melitensis - Vitry, M-A., Hanot Mambres, D., De Trez, C., Akira, S., Ryffel, B., Letesson, J-J. & Muraille, E. 2014 In : Journal of immunology. 192, 8, p. 3740-52 13 p.

Research output: Research - peer-reviewArticle

G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus - Deghelt, M., Mullier, C., Sternon, J-F., Francis, N., Laloux, G., Dotreppe, D., Van der Henst, C., Jacobs-Wagner, C., Letesson, J-J. & De Bolle, X. 2014 In : Nature Communications. 5, p. 4366 11 p.

Research output: Research - peer-reviewArticle

Brucella abortus depends on pyruvate phosphate dikinase and malic enzyme but not on Fbp and GlpX fructose-1,6-bisphosphatases for full virulence in laboratory models - Zúñiga-Ripa, A., Barbier, T., Conde-Álvarez, R., Martínez-Gómez, E., Palacios-Chaves, L., Gil-Ramírez, Y., Grilló, M. J., Letesson, J-J., Iriarte, M. & Moriyón, I. 2014 In : Journal of bacteriology.

Research output: Research - peer-reviewArticle

Brucella melitensis invades murine erythrocytes during infection - Vitry, M-A., Hanot-Mambres, D., Deghelt, M., Hack, K., Machelart, A., Lhomme, F., Vanderwinden, J-M., Vermeersch, M., De Trez, C., Pérez-Morga, D., Letesson, J-J. & Muraille, E. 2014 In : Infection and immunity. 82, 9, p. 3927-3938 12 p.

Research output: Research - peer-reviewArticle

Brucella, nitrogen and virulence - Ronneau, S., Moussa, S., Barbier, T., Conde-Álvarez, R., Zuniga-Ripa, A., Moriyon, I. & Letesson, J-J. 2014 In : Critical reviews in microbiology. p. 1-19 19 p.

Research output: Research - peer-reviewArticle

On the link between cell cycle and infection of the Alphaproteobacterium Brucella abortus - Letesson, J-J., De Bolle, X. & Deghelt, M. 2014 In : microbial cell. 1, 10, p. 346-348

Research output: Research - peer-reviewArticle

Quorum sensing and self-quorum quenching in the intracellular pathogen Brucella melitensis - Terwagne, M., Mirabella, A., Lemaire, J., Deschamps, C., De Bolle, X. & Letesson, J-J. 11 Dec 2013 In : PloS one. 8, 12, e82514

Research output: Research - peer-reviewArticle

The Brucella pathogens are polarized bacteria - Van der Henst, C., de Barsy, M., Zorreguieta, A., Letesson, J-J. & De Bolle, X. 1 Dec 2013 In : Microbes and infection : a journal on infectious agents and host defenses. 15, 14-15, p. 998-1004 7 p.

Research output: Research - peer-reviewArticle

Innate immune recognition of flagellin limits systemic persistence of Brucella - Terwagne, M., Ferooz, J., Rolán, H. G., Sun, Y. H., Atluri, V., Xavier, M. N., Franchi, L., Núñez, G., Legrand, T., Flavell, R. A., De Bolle, X., Letesson, J-J. & Tsolis, R. M. 1 Jun 2013 In : Cellular microbiology. 15, 6, p. 942-960 19 p.

Research output: Research - peer-reviewArticle

Brucella melitensis MucR, an orthologue of Sinorhizobium meliloti MucR, is involved in resistance to oxidative, detergent, and saline stresses and cell envelope modifications - Mirabella, A., Terwagne, M., Zygmunt, M. S., Cloeckaert, A., De Bolle, X. & Letesson, J. J. 1 Feb 2013 In : Journal of bacteriology. 195, 3, p. 453-465 13 p.

Research output: Research - peer-reviewArticle

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions - Salcedo, S. P., Marchesini, M. I., Degos, C., Terwagne, M., Von Bargen, K., Lepidi, H., Herrmann, C. K., Santos Lacerda, T. L., Imbert, P. R. C., Pierre, P., Alexopoulou, L., Letesson, J-J., Comerci, D. J. & Gorvel, J-P. 2013 In : Frontiers in cellular and infection microbiology. 3, p. 28

Research output: Research - peer-reviewArticle

Crucial Role of Gamma Interferon-Producing CD4+ Th1 Cells but Dispensable Function of CD8+ T Cell, B Cell, Th2, and Th17 Responses in the Control of Brucella melitensis Infection in Mice - Vitry, M-A., De Trez, C., Goriely, S., Dumoutier, L., Akira, S., Ryffel, B., Carlier, Y., Letesson, J-J. & Muraille, E. 2012 In : Infection and Immunity. 80, 12, p. 4271-80 10 p.

Research output: Research - peer-reviewArticle

Immunogenicity of eight Mycobacterium avium subsp. paratuberculosis specific antigens in DNA vaccinated and Map infected mice - Roupie, V., Viart, S., Leroy, B., Romano, M., Trinchero, N., Govaerts, M., Letesson, J-J., Wattiez, R. & Huygen, K. 2012 In : Veterinary immunology and immunopathology. 145, 1-2, p. 74-85 12 p.

Research output: Research - peer-reviewArticle

The two-component system PrlS/PrlR of Brucella melitensis is required for persistence in mice and appears to respond to ionic strength - Mirabella, A., Yañez Villanueva, R-M., Delrue, R-M., Uzureau, S., Zygmunt, M. S., Cloeckaert, A., De Bolle, X. & Letesson, J-J. 2012 In : Microbiology. 158, Pt 10, p. 2642-51 10 p.

Research output: Research - peer-reviewArticle

The histidine kinase PdhS controls cell cycle progression of the pathogenic alphaproteobacterium Brucella abortus - Van der Henst, C., Beaufay, F., Mignolet, J., Didembourg, C., Colinet, J., Hallet, B., Letesson, J-J. & De Bolle, X. 2012 In : Journal of bacteriology. 194, 19, p. 5305-14 10 p.

Research output: Research - peer-reviewArticle

In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice - Copin, R., Vitry, M-A., Hanot Mambres, D., Machelart, A., De Trez, C., Vanderwinden, J-M., Magez, S., Akira, S., Ryffel, B., Carlier, Y., Letesson, J-J. & Muraille, E. 2012 In : Plos Pathogens. 8, 3, p. e1002575

Research output: Research - peer-reviewArticle

Brucella quorum sensing : much more than sensing quorum - Letesson, J-J., Terwagne, M. & Uzureau-Bonnot, S. 2012 Brucella: Molecular Microbiology and Genomics | Book . O'Callaghan, D. & Lopez-Goni, I. (eds.). Caister Academic Press

Research output: ResearchChapter (peer-reviewed)

Small GTPases and Brucella entry into the endoplasmic reticulum - de Bolle, X., Letesson, J-J. & Gorvel, J-P. 2012 In : Biochemical Society transactions. 40, 6, p. 1348-52 5 p.

Research output: Research - peer-reviewArticle

Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century - Godfroid, J., Scholz, H. C., Barbier, T., Nicolas, C., Letesson, J-J., Wattiau, P., Fretin, D., Whatmore, A. M., Cloeckaert, A., Blasco, J. M., Moriyon, I., Saegerman, C., Muma, J. B., Al Dahouk, S. & Neubauer, H. 1 Nov 2011 In : Preventive Veterinary Medicine. 102, 2, p. 118-131 14 p.

Research output: Research - peer-reviewArticle

Brucella adaptation and survival at the crossroad of metabolism and virulence - Barbier, T., Nicolas, C. & Letesson, J-J. 3 Oct 2011 In : FEBS Letters. 585, 19, p. 2929-2934 6 p.

Research output: Research - peer-reviewArticle

Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2 - de Barsy, M., Jamet, A., Filopon, D., Nicolas, C., Laloux, G., Rual, J-F., Muller, A., Twizere, J-C., Nkengfac, B., Vandenhaute, J., Hill, D. E., Salcedo, S. P., Gorvel, J-P., Letesson, J-J. & De Bolle, X. 1 Jul 2011 In : Cellular microbiology. 13, 7, p. 1044-58 15 p.

Research output: Research - peer-reviewArticle

RpoE1, an extracytoplasmic function sigma factor, is a repressor of the flagellar system in Brucella melitensis - Ferooz, J., Lemaire, J., Delory, M., De Bolle, X. & Letesson, J-J. 1 May 2011 In : Microbiology. 157, 5, p. 1263-8 6 p.

Research output: Research - peer-reviewArticle

The alkylation response protein AidB is localized at the new poles and constriction sites in Brucella abortus - Dotreppe, D., Mullier, C., Letesson, J-J. & De Bolle, X. 1 Jan 2011 In : BMC microbiology. 11, p. 257

Research output: Research - peer-reviewArticle

Role of FlbT in flagellin production in Brucella melitensis - Ferooz, J., Lemaire, J. & Letesson, J-J. 2011 In : Microbiology. 157, Pt 5, p. 1253-62 10 p.

Research output: Research - peer-reviewArticle

Is the autophagic pathway implicated in the replication of Brucella abortus ? - Goffin, E., De Bolle, X., Letesson, J-J., Van der Henst, C., de Barsy, M., Raes, M., Arnould, T., Jadot, M. & Hamer, I. 2011

Research output: Research - peer-reviewPoster

Brucella melitensis 16M produces a mannan and other extracellular matrix components typical of a biofilm - Godefroid, M., Uzureau, S., Mirabella, A., De Bolle, X., Letesson, J-J., Svensson, M. V., Widmalm, G., Cambier, P. & Van Cutsem, P. 1 Aug 2010 In : FEMS Immunology and Medical Microbiology. 59, 3, p. 364-377 14 p.

Research output: Research - peer-reviewArticle

Global analysis of quorum sensing targets in the intracellular pathogen brucella melitensis 16 M - Uzureau, S., Lemaire, J., Delaive, E., Dieu, M., Gaigneaux, A., Raes, M., De Bolle, X. & Letesson, J-J. 4 Jun 2010 In : Journal of Proteome Research. 9, 6, p. 3200-3217 18 p.

Research output: Research - peer-reviewArticle

Functional characterization of the incomplete phosphotransferase system (PTS) of the intracellular pathogen brucella melitensis - Dozot, M., Nicolas, C., Copin, R., de Bolle, X., Letesson, J-J., Poncet, S., Bouraoui, H., Mazé, A. & Deutscher, J. 1 Jan 2010 In : PLoS ONE. 5, 9, p. 1-16 16 p.

Research output: Research - peer-reviewArticle

PdhS, an old-pole-localized histidine kinase, recruits the fumarase FumC in Brucella abortus - Mignolet, J., Van Der Henst, C., Nicolas, C., Deghelt, M., Dotreppe, D., Letesson, J-J. & De Bolle, X. (ed.) 2010 In : J Bacteriol. 192, 12, p. 3235-32359 29125 p.

Research output: ResearchArticle

Morphological analysis of the sheathed flagellum of Brucella melitensis - Ferooz, J. & Letesson, J-J. 2010 In : BMC Res Notes. 3

Research output: ResearchArticle

Rough mutants defective in core and O-polysaccharide synthesis and export induce antibodies reacting in an indirect ELISA with smooth lipopolysaccharide and are less effective than Rev 1 vaccine against Brucella melitensis infection of sheep - Barrio, M. B., Jacques, I., Zygmunt, M. S., Grilló, M. J., Muñoz, P. M., de Miguel, M. J., Marín, C. M., Blasco, J. M., González, D., Moriyón, I., Barberán, M., Letesson, J-J. & Gorvel, J-P. 10 Mar 2009 In : Vaccine. 27, 11, p. 1741-1749 9 p.

Research output: Research - peer-reviewArticle

Brucellosis vaccines: Assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export - González, D., Conde-Álvarez, R., López-Goñi, I., Iriarte, M., Moriyón, I., Grilló, M-J., De Miguel, M-J., Muñoz, P., Marín, C-M., Blasco, J-M., Ali, T., Widmalm, G., Arce-Gorvel, V., Gorvel, J-P., Delrue, R-M., Letesson, J-J., Weintraub, A. & Zygmunt, M. 23 Jul 2008 In : PLoS ONE. 3, 7

Research output: Research - peer-reviewArticle